The Prevalence of Hypercholesterolaemia and its Relationship With Albuminuria in Insulin-dependent Diabetic Patients: An Epidemiological Study
| العنوان: | The Prevalence of Hypercholesterolaemia and its Relationship With Albuminuria in Insulin-dependent Diabetic Patients: An Epidemiological Study |
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| المؤلفون: | A. Kofoed-Enevoldsen, A.B. Haaber, Tonny Jensen |
| المصدر: | Diabetic Medicine. 9:557-561 |
| بيانات النشر: | Wiley, 1992. |
| سنة النشر: | 1992 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Denmark, Endocrinology, Diabetes and Metabolism, Hypercholesterolemia, Population, Gastroenterology, Nephropathy, Excretion, Endocrinology, Internal medicine, Prevalence, Internal Medicine, medicine, Albuminuria, Humans, Outpatient clinic, education, Glycated Hemoglobin, Type 1 diabetes, education.field_of_study, business.industry, medicine.disease, Cholesterol, Diabetes Mellitus, Type 1, Metabolic control analysis, Female, Microalbuminuria, medicine.symptom, business |
| الوصف: | To assess the prevalence of hypercholesterolaemia and its relationship with metabolic control and urinary albumin excretion in Type 1 diabetic patients, all 1577 insulin-dependent patients attending the outpatient clinic at the Steno Memorial Hospital were studied. None had previously received lipid-lowering drugs. Hypercholesterolaemia, defined as plasma concentration of cholesterol above 6.4 mmol l-1 was found in 156 patients (10%) (95%) confidence intervals (CI) 8.4-11.5%) compared with 11% in the Danish background population. Compared with the normolipidaemic diabetic patients, the hyperlipidaemic patients were older (42 vs 37 years: p less than 0.001, 95% CI for difference in means 3-7 years), they had a higher glycosylated HbA1C (9.2 vs 8.6%, p less than 0.001, 95% CI for difference in means 0.4-1.3%) and their urinary albumin excretion was 32 vs 12 mg 24 h-1, p less than 0.001. Of the 1577 diabetic patients, 1084 patients (73%) had normal urinary albumin excretion (UAE less than 30 mg 24 h-1), 255 (17%) had microalbuminuria (UAE 30-300 mg 24 h-1) and 136 (9%) had overt clinical nephropathy (UAE greater than 300 mg 24 h-1). The plasma concentration of cholesterol rose significantly with increasing urinary albumin excretion; normoalbuminuric 4.78 mmol l-1 +/- 1.06 (mean +/- SD); microalbuminuric: 5.12 mmol l-1 +/- 1.23 and macroalbuminuric: 4.89 mmol l-1 +/- 1.38 (p less than 0.001). The influence of metabolic control on the plasma level of cholesterol was of only minor clinical importance.(ABSTRACT TRUNCATED AT 250 WORDS) |
| تدمد: | 1464-5491 0742-3071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043403ef2f775c00d85920439ecf559fTest https://doi.org/10.1111/j.1464-5491.1992.tb01838.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....043403ef2f775c00d85920439ecf559f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
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