المؤلفون: Kolage Sakshi, Shrutika Mote

مصطلحات موضوعية: AD – Alzheimer's Disease, APOE – Apolipoprotein, APP – Amyloid Precursor Protein, Aβ – Amyloid Beta Precursor, MCI – Mild Cognitive Impairment

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981430a53382fe088b49ee0eb437059dTest

المؤلفون: Liang Han, Chen Jiang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2306-2325 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PSMA, prostate-specific membrane antigen, Gd, gadolinium, BACE1, β-secretase 1, MMP9, metalloproteinase-9, PLGA, poly(lactic-co-glycolic acid), Disease, Review, Aβ, amyloid beta, ICAM-1, intercellular adhesion molecule-1, KCa, calcium-dependent potassium channels, PD, Parkinson's disease, LDL, low density lipoprotein, PEG, polyethyleneglycol, Epilepsy, 0302 clinical medicine, P-gp, P-glycoprotein, Medicine, LRP1, LDLR-related protein 1, General Pharmacology, Toxicology and Pharmaceutics, BBB, blood–brain barrier, siRNA, short interfering RNA, 0303 health sciences, ZO1, zona occludens 1, LAT1, L-type amino acid transporter 1, LDLR, LDL receptor, RBC, red blood cell, AMT, alpha-methyl-l-tryptophan, DTPA-Gd, Gd-diethyltriaminepentaacetic acid, RAGE, receptor for advanced glycosylation end products, VEGF, vascular endothelial growth factor, Drug delivery systems, KATP, ATP-sensitive potassium channels, medicine.anatomical_structure, TJ, tight junction, 030220 oncology & carcinogenesis, Drug delivery, cardiovascular system, AD, Alzheimer's disease, Brain diseases, RMT, receptor-mediated transcytosis, Traumatic brain injury, Brain tumor, BDNF, brain derived neurotrophic factor, Brain-targeting, TfR, transferrin receptor, RM1-950, Blood–brain barrier, TBI, traumatic brain injury, MFSD2A, major facilitator superfamily domain-containing protein 2a, 03 medical and health sciences, ROS, reactive oxygen species, EPR, enhanced permeability and retention, NPs, nanoparticles, 030304 developmental biology, CMT, carrier-mediated transportation, PEG-PLGA, polyethyleneglycol-poly(lactic-co-glycolic acid), business.industry, LFA-1, lymphocyte function associated antigen-1, GLUT1, glucose transporter-1, medicine.disease, tPA, tissue plasminogen activator, Brain targeting, BTB, blood–brain tumor barrier, nervous system, Nanoparticles, Nasal administration, Therapeutics. Pharmacology, business, Neuroscience, MRI, magnetic resonance imaging

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a05eff9f72ac70fe48cb5ed9a111b5bTest
http://www.sciencedirect.com/science/article/pii/S2211383520308522Test

المؤلفون: Tongtong Miao, Haiyan Chen, Jiang Ni, Liang Han, Naveed Ullah Khan, Xiufeng Ju

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1341-1354 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: medicine.medical_treatment, PLGA, poly(lactic-co-glycolic acid), PLGA-PLL, poly(lactic-co-glycolic acid)-poly(ε-carbobenzoxy-l-lysine), t1/2, half time, Aβ, amyloid beta, DMSO, dimethyl sulfoxide, LRP1, low density lipoprotein receptor-related protein 1, PVA, polyvinyl alcohol, Targeted therapy, Blood‒brain barrier, 0302 clinical medicine, MAL-PEG-SCM, maleimide polyethylene glycol succinimidyl carboxymethyl ester, Fusion peptide, Medicine, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, MMP, A, angiopep-2, AUC0‒t, area under the curve from zero to time t, Brain clearance, LRP1, i, insensitive GDQGIAGF, MRT0‒t, mean residence time from zero to time t, MCM, MDA-MB-231Br-HER2 conditioned medium, medicine.anatomical_structure, Transcytosis, Abluminal LRP1, 030220 oncology & carcinogenesis, Drug delivery, Original Article, medicine.drug, SDS, sodium dodecyl sulfate, 231Br, MDA-MB-231Br-HER2, RM1-950, Lapatinib, Blood–brain barrier, 03 medical and health sciences, FBS, fetal bovine serum, K, KAAYSL, BBB, blood‒brain barrier, Doxorubicin, NPs, nanoparticles, 030304 developmental biology, business.industry, s, sensitive VPMS-MRGG, Amyloid beta, CI, combination index, Fa, the fraction of tumor cells affected, MMP1, matrix metalloproteinase-1, BCBMs, breast cancer brain metastases, medicine.disease, DOX, doxorubicin, BMECs, brain microvascular endothelial cells, tPA, tissue plasminogen activator, PLL, poly(ε-carbobenzoxy-l-lysine), Breast cancer brain metastases, DMEM, Dulbecco's modified eagle medium, LAP, lapatinib, Cancer research, Nanoparticles, Therapeutics. Pharmacology, business, CL, clearance, Brain metastasis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8871da41ea9c8b40f305cc15fb1a6fTest
https://doi.org/10.1016/j.apsb.2020.10.015Test

المؤلفون: Alshaimaa A.I. Alghriany, Mona M. Atia

المصدر: Toxicology Reports
Toxicology Reports, Vol 8, Iss, Pp 1156-1168 (2021)

مصطلحات موضوعية: MAO-A and B, monoamine oxidase A, B, Hippocampal cells, Monoamine oxidase, Health, Toxicology and Mutagenesis, Adipose tissue, Apoptosis, Aβ, amyloid beta, 010501 environmental sciences, Hippocampal formation, Pharmacology, Toxicology, 01 natural sciences, Al2O3-NPs, Aluminum oxide nanoparticles, 03 medical and health sciences, ROS, reactive oxygen species, 0302 clinical medicine, SOX2, RA1190-1270, Oct4, octamer-binding transcription factor 4, Adipose-Derived mesenchymal stem cells, TEM, transmission electron microscopy, ComputingMethodologies_COMPUTERGRAPHICS, 0105 earth and related environmental sciences, Aluminum oxide nanoparticles, Chemistry, EGTA, ethylene glycol tetraacetic acid, Mesenchymal stem cell, Regular Article, AD-MSCs, adipose-derived mesenchymal stem cells, Transplantation, Toxicology. Poisons, Toxicity, Sox2, sex-determining region Y-box 2, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c740f58f189239b6b9f7cd8b63a59066Test
https://doi.org/10.1016/j.toxrep.2021.06.003Test

المؤلفون: Elena Camporesi, Johanna Nilsson, Agathe Vrillon, Emmanuel Cognat, Claire Hourregue, Henrik Zetterberg, Kaj Blennow, Bruno Becker, Ann Brinkmalm, Claire Paquet, Gunnar Brinkmalm

المصدر: EBioMedicine
EBioMedicine, Vol 75, Iss, Pp 103793-(2022)

مصطلحات موضوعية: Medicine (General), GAP43, growth-associated protein 43, F/T, freeze/thaw, Cell Adhesion Molecules, Neuronal, NRXNs, neurexins, tau Proteins, Nlgns, neuroligins, CNS, central nervous system, MMSE, mini-mental state examination, General Biochemistry, Genetics and Molecular Biology, Article, neuroligins, NFTs, neurofibrillary tangles, Mass Spectrometry, R5-920, APP, amyloid precursor protein, ELISA, enzyme-linked immunosorbent assays, Alzheimer Disease, PRM, parallel reaction monitoring, Humans, Cognitive Dysfunction, IS, internal standard, t-tau, total-tau, Neural Cell Adhesion Molecules, bvFTD, behavioral variant frontotemporal dementia, Amyloid beta-Peptides, neurexins, DLB, dementia with Lewy bodies, SPE, solid-phase extraction, Calcium-Binding Proteins, biomarkers, CV, coefficient of variation, Neurodegenerative Diseases, General Medicine, synaptic proteins, Alzheimer's disease, AD, Alzheimer´s disease, Aβo, Aβ oligomers, Aβ, amyloid-beta, QC, quality control, MS, mass spectrometry, MCI, mild cognitive impairment, Medicine, Aβ1-42, Aβ peptide 1-42, p-tau, phospho-tau, ABC, Ammonium bicarbonate, VaD, vascular dementia, MRI, magnetic resonance imaging

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe482bf0c3d4349983f3843c40250d5Test
http://europepmc.org/articles/PMC8743209Test

المؤلفون: Adeola Shobo, Nicholas James, Daniel Dai, Alexander Röntgen, Corbin Black, Jean-Robert Kwizera, Mark A. Hancock, Khanh Huy Bui, Gerhard Multhaup

المساهمون: Apollo - University of Cambridge Repository

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Male, AUC, area-under the curve, sD-AIP, scrambled version of D-AIP (EFRKFTGG), Mice, Transgenic, CHCA, α-cyano-4-hydroxy cinnamic acid, AD, Alzheimer’s disease, Biochemistry, D-AIP, AIP (RGTFEGKF) synthesized using D-amino acids, 03 medical and health sciences, Mice, 0302 clinical medicine, APP, amyloid precursor protein, Alzheimer Disease, amyloid-beta42 peptide, Cmax, maximum concentration reached, ThT, thioflavin T, CL/F, apparent total clearance from plasma after oral administration, Animals, IS, internal standard, Tmax, time at which maximum concentration is reached, TEM, transmission electron microscopy, Molecular Biology, AIP, Aβ42-oligomer interacting peptide, L-AIP, AIP (RGTFEGKF) synthesized using L-amino acids, 030304 developmental biology, 0303 health sciences, Amyloid beta-Peptides, t½, elimination half-life, anti-amyloid, Brain, amyloid-beta42-oligomer interacting peptide (AIP), Cell Biology, MSI, mass spectrometry imaging, Peptide Fragments, 3. Good health, Aβ, amyloid-beta, BBB, blood brain barrier, PK, pharmacokinetics, Female, MRT, mean residence time, Vd, apparent volume of distribution, amyloid-beta oligomers, 030217 neurology & neurosurgery, Research Article

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29a2223836effe65f042554ddc2330dTest
https://www.repository.cam.ac.uk/handle/1810/334182Test

المؤلفون: Jerzy Leszek, Andrew Want, Urszula Wojda, Wioleta Grabowska-Pyrzewicz

المصدر: EBioMedicine
EBioMedicine, Vol 74, Iss, Pp 103691-(2021)

مصطلحات موضوعية: antisense oligonucleotide, Medicine (General), Amyloid beta, Genetic enhancement, RNA therapy, RNA delivery, Disease, Review, Bioinformatics, General Biochemistry, Genetics and Molecular Biology, ASO, Antisense oligonucleotide, R5-920, Alzheimer Disease, microRNA, medicine, Aβ, Amyloid beta, Humans, Gene Regulatory Networks, Molecular Targeted Therapy, RNA, Messenger, Neurodegeneration, miRNA, Brain Chemistry, Messenger RNA, therapy, clinical trials, CSF, Cerebrospinal fluid, biology, business.industry, Neurofibrillary tangle, General Medicine, Alzheimer's disease, Oligonucleotides, Antisense, medicine.disease, BBB, Blood-brain barrier, gene therapy, Clinical trial, MicroRNAs, Gene Expression Regulation, NFT, Neurofibrillary tangle, biology.protein, Medicine, AD, Alzheimer's disease, business, preclinical testing, APP, Amyloid precursor protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29cce4e1140f2066726bcb229d5e3c7Test
http://europepmc.org/articles/PMC8602003Test

المؤلفون: Sun Hee Hyun, Yi-Seong Kwak, Chang-Kyun Han, Muhammad Irfan, Man Hee Rhee

المصدر: Journal of Ginseng Research, Vol 44, Iss 4, Pp 538-543 (2020)
Journal of Ginseng Research

مصطلحات موضوعية: 0301 basic medicine, eNOS, Endothelial nitric oxide synthase, Ginsenoside, cGMP, Cyclic guanosine 3′,5′-monophosphate, medicine.medical_treatment, PI3K, Phosphatidylinositol-3 kinase, Inflammation, Review, Pharmacology, Biochemistry, Genetics and Molecular Biology (miscellaneous), NO, Nitric oxide, complex mixtures, 03 medical and health sciences, Ginseng, chemistry.chemical_compound, 0302 clinical medicine, Nutraceutical, Akt, Protein kinase B, CVD, Cardiovascular disease, Diabetes mellitus, lcsh:Botany, Adaptogen, Vascular endothelium, medicine, Aβ, Amyloid-beta, business.industry, Panax ginseng, food and beverages, medicine.disease, lcsh:QK1-989, 030104 developmental biology, Complementary and alternative medicine, chemistry, 030220 oncology & carcinogenesis, AD, Alzheimer's disease, Cardioprotective, medicine.symptom, business, APP, Amyloid precursor protein, Vasoconstriction, Homeostasis, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7cd737611684ea5e87a667bd3a4d0dTest
http://www.sciencedirect.com/science/article/pii/S1226845320300567Test

المؤلفون: Rami Beiram, Sheikh Azimullah, Richard L. Jayaraj

المصدر: Saudi Journal of Biological Sciences, Vol 27, Iss 2, Pp 736-750 (2020)
Saudi Journal of Biological Sciences

مصطلحات موضوعية: GSK-3β, Glycogen synthase kinase 3 beta, 0106 biological sciences, 0301 basic medicine, MRI, Magnetic resonance imaging, ECE-1, Endotherin converting enzyme 1, IR, Insulin receptor, Type 2 diabetes, Disease, Bioinformatics, 01 natural sciences, LPA, Lipophosphatidic acid, Diabetes mellitus, BACE1, Beta-secretase 1, Arab population, ADAMTS9, ADAM Metallopeptidase With Thrombospondin Type 1 Motif 9, Medicine, Glucose homeostasis, lcsh:QH301-705.5, MC4R, Melanocortin 4 receptor, IGF-1, Insulin-like growth factor 1, NDUFS3, NADH:Ubiquinone Oxidoreductase Core Subunit S3, biology, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, RAB1A, Ras-related protein 1A, Insulin signaling, FRMD4A, FERM Domain Containing 4A, NFT, Neurofibrillary tangles, TFAP2B, Transcription Factor AP-2 Beta, BBB, Blood-Brain Barrier, Pit-PET, Pittsburgh compound B- positron emission tomography, FDG-PET, Fluorodeoxyglucose- positron emission tomography, Anti-diabetic drugs, T1DM, Type 1 Diabetes Mellitus, PP2A, Protein phosphatase 2, ApoE, Apolipoprotein E, General Agricultural and Biological Sciences, Alzheimer’s disease, IR, Insulin resistance, MCI, Myocardial infarction, TCF7L2, Transcription Factor 7 Like 2, PI3K, Phosphoinositide-3, NOTCH4, Neurogenic locus notch homolog protein 4, AGPAT1, 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha, BMI, Body mass index, MENA, Middle East North African, AAV, Adeno-associated virus, AD, Alzheimer’s disease, Article, CALR, calreticulin gene, 03 medical and health sciences, Insulin resistance, FTO, Fat Mass and Obesity Associated Gene, GLP-1, Glucagon like peptide, Dementia, Aβ, Amyloid-beta, SORT, Sortilin, PPAR-γ2, Peroxisome proliferator-activated receptor gamma 2, CSF, Cerebrospinal fluid, MG-H1, Methylglyoxal-hydroimidazolone isomer trifluoroactic acid salt, COX-2, Cyclooxygenase 2, business.industry, DM, Diabetes mellitus, STZ, Streptozotocin, medicine.disease, CIP2A, Cancerous Inhibitor Of Protein Phosphatase 2A, Obesity, Insulin receptor, 030104 developmental biology, DUSP9, Dual Specificity Phosphatase 9, lcsh:Biology (General), ABCA1, ATP binding cassette subfamily A member 1, IDE, Insulin degrading enzyme, biology.protein, GNPDA2, Glucosamine-6-phosphate deaminase 2, business, T2DM, Type 2 Diabetes Mellitus, 010606 plant biology & botany

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82087843d8727a5c0d4d07ba5ff6b9bdTest
http://www.sciencedirect.com/science/article/pii/S1319562X19303286Test

المؤلفون: Catarina Perdigão, Tatiana Burrinha, Mariana A. Barata, Claudia G. Almeida

المساهمون: iNOVA4Health - pólo NMS, Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

المصدر: The Journal of Biological Chemistry
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

مصطلحات موضوعية: Small interfering RNA, Bin1, SNX4, sorting nexin-4, LOAD, late-onset Alzheimer's disease, Endocytic recycling, medicine.disease_cause, BAR, BIN1/amphiphysin/RVS167 domain, GWAS, genome-wide association studies, Biochemistry, Mice, 0302 clinical medicine, neurodegenerative disease, BIN1, bridging integrator 1/MYC box-dependent-interacting protein 1, cell biology, Amyloid precursor protein, Aspartic Acid Endopeptidases, genetic polymorphism, pAb, polyclonal antibody, SDS-PAGE, sodium dodecyl sulfate–polyacrylamide gel electrophoresis, GFP, green fluorescent protein, 0303 health sciences, Mutation, Gene knockdown, Mice, Inbred BALB C, biology, EGTA, ethylene glycol tetraacetic acid, SH3, src homology 3 domain, amyloid-beta (Aβ), Nuclear Proteins, HRP, horseradish peroxidase, BACE1, IP, immunoprecipitation, Alzheimer's disease, CLAP, clathrin and AP2-binding domain, BACE1, β-site APP-cleaving enzyme 1 or β-secretase 1, 3. Good health, Cell biology, RVS167, reduced viability upon starvation protein 167, Aβ, amyloid-beta, Protein Transport, AD, Alzheimer's disease, Research Article, PIC, protease inhibitor cocktail, Amyloid beta, Endosome, IgG, immunoglobulin G, PBS, phosphate-buffered saline, AP-2, adaptor protein complex 2, CTF, carboxyl-terminal fragment, Endosomes, RIPA, radio-immunoprecipitation assay, Polymorphism, Single Nucleotide, endocytic recycling, EEA1, 03 medical and health sciences, cDNA, complementary DNA, FBS, fetal bovine serum, Alzheimer Disease, genetic disease, trafficking, APP, amyloid precursor protein, medicine, Animals, Humans, APOE4, apolipoprotein E ε4, mAb, monoclonal antibody, Molecular Biology, 030304 developmental biology, Adaptor Proteins, Signal Transducing, FAD, familial Alzheimer's disease, KD, knockdown, Amyloid beta-Peptides, N2a, Neuro2a, Tumor Suppressor Proteins, Cell Biology, DMEM, Dulbecco's modified eagle medium, siRNA, small interfering RNA, biology.protein, ARF6, ADP-ribosylation factor 6, BSA, bovine serum albumin, EEA1, early endosome antigen 1, Amyloid Precursor Protein Secretases, 030217 neurology & neurosurgery, OE, overexpression

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2de6c2693d9bec20fda2c7ec0e76d7cTest
https://hdl.handle.net/10362/125755Test