نتائج البحث - "Aβ, amyloid β"

المصدر: Metabolism Open, Vol 12, Iss, Pp 100125-(2021)
Nielsen, J E, Maltesen, R G, Havelund, J F, Færgeman, N J, Gotfredsen, C H, Vestergård, K, Kristensen, S R & Pedersen, S 2021, ' Characterising Alzheimer's disease through integrative NMR-and LC-MS-based metabolomics ', Metabolism Open, vol. 12, 100125 . https://doi.org/10.1016/j.metop.2021.100125Test
Nielsen, J E, Maltesen, R G, Havelund, J F, Færgeman, N J, Gotfredsen, C H, Vestergård, K, Kristensen, S R & Pedersen, S 2021, ' Characterising Alzheimer's disease through integrative NMR-and LC-MS-based metabolomics ', Metabolism open, vol. 12, 100125 . https://doi.org/10.1016/j.metop.2021.100125Test
Metabolism Open

مصطلحات موضوعية: Purine, p-tau, Phospho-tau, Aβ, Amyloid-β, Physiology, Guanosine, QD415-436, Pharmacology, Biochemistry, ROC, Receiver operating characteristics, Nuclear magnetic resonance, MMSE, Mini-mental state examination, chemistry.chemical_compound, Metabolomics, Valine, medicine, Metabolites, sPLS-DA, Sparse partial least squared discriminant analysis, QP1-981, FAQ, Functional activities questionnaire, Inosine, AD, Alzheimer's Disease, EVs, Extracellular vesicles, chemistry.chemical_classification, CSF, Cerebrospinal fluid, PCA, Principal component analysis, Mass spectrometry, CNS, Central nervous system, business.industry, CV, Cross-validation, MCI, Mild cognitive impairment, General Medicine, Metabolism, Extracellular vesicles, AUC, Area under the curve, BBB, Blood-brain barrier, Extracellular vehicles, Fold change, t-tau, Total-tau, Amino acid, ACE, Addenbrooke's cognitive examination, Blood, chemistry, Alzheimer, FDR, False discovery rate, business, BCAA, Branched-chain amino acid, Articles from the Clinical Metabolomics Special Issue, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36710fd7cf80b8c201090924500ca109Test
http://www.sciencedirect.com/science/article/pii/S2589936821000499Test

5

Human cerebral vascular amyloid contains both antiparallel and parallel in-register Aβ40 fibrils

المؤلفون: Xiaoyue Zhu, Annemieke J.M. Rozemuller, Baayla D.C. Boon, Steven O. Smith, Judianne Davis, William E. Van Nostrand, Brandon A. Irizarry

المساهمون: Pathology, Amsterdam Neuroscience - Neurodegeneration

المصدر: Journal of Biological Chemistry, 297(5):101259. American Society for Biochemistry and Molecular Biology Inc.
Irizarry, B A, Davis, J, Zhu, X, Boon, B D C, Rozemuller, A J M, van Nostrand, W E & Smith, S O 2021, ' Human cerebral vascular amyloid contains both antiparallel and parallel in-register Aβ40 fibrils ', Journal of Biological Chemistry, vol. 297, no. 5, 101259 . https://doi.org/10.1016/j.jbc.2021.101259Test
The Journal of Biological Chemistry

مصطلحات موضوعية: Male, Aβ, amyloid β, cryo-EM, electron cryo-microscopy, Amyloid, Mutation, Missense, macromolecular substances, amyloid-β, Fibril, Antiparallel (biochemistry), Biochemistry, polymorphism, Alzheimer Disease, APP, amyloid precursor protein, ATR, attenuated total reflectance, medicine, Amyloid precursor protein, Humans, CAA, cerebral amyloid angiopathy, TEM, transmission electron microscopy, Nuclear Magnetic Resonance, Biomolecular, cerebral amyloid angiopathy, Molecular Biology, Vascular tissue, Aged, Laser capture microdissection, Amyloid beta-Peptides, biology, Chemistry, DARR, dipolar-assisted rotational resonance, CAA/s, sporadic cerebral amyloid angiopathy, Brain, ELISA, enzyme-linked immunosorbent assay, Cell Biology, Human brain, Alzheimer's disease, MAS, magic angle spinning, medicine.disease, Peptide Fragments, TBS, Tris-HCl buffered saline, FTIR, Fourier transform infrared, medicine.anatomical_structure, Amino Acid Substitution, Biophysics, biology.protein, antiparallel fibrils, AD, Alzheimer's disease, Cerebral amyloid angiopathy, LCM, laser capture microdissection, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd3f4ab805e95733c6739472c1ffb5eTest
https://research.vumc.nl/en/publications/26e2698a-be3a-4407-96df-0100a196db73Test

6

Effect of the electro-acupuncture on senile plaques and its formation in APP+/PS1+ double transgenic mice

المؤلفون: Kai-Hui Wu, Shu-Juan Zhu, Hua-Jun Sheng, Yiying Wang, Yan-Jun Wu, Jin Jin Xu, Cheng-Lin Tang, Qing-Hua Yang

المصدر: Genes & Diseases

مصطلحات موضوعية: Genetically modified mouse, medicine.medical_specialty, Amyloid β-protein, AchE, cholinesterase, Senile plaques, Stimulation, Biochemistry, Article, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Western blot, SOD, superoxide dismutase, Internal medicine, mental disorders, medicine, Insulin-degrading enzyme, Amyloid precursor protein, Electro-acupuncture, Transgenic mice, IDE, insulin degrading enzyme, Ach, aetylcholine, Molecular Biology, Genetics (clinical), EA, electro-acupuncture, amyloid precursor protein, BACE1, Aβ, amyloid β-protein, medicine.diagnostic_test, biology, business.industry, β－, site APP cleavage, Cell Biology, Alzheimer's disease, APP, β－, Endocrinology, SPs, senile plaques, 030220 oncology & carcinogenesis, biology.protein, Immunohistochemistry, ChAT, aetylcholine tansferase, AD, Alzheimer's disease, business, IHC, immunohistochemistry, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37fac6164f11fe598d500558a3c9f5bcTest
https://doi.org/10.1016/j.gendis.2018.06.002Test

7

Therapeutic antibodies – natural and pathological barriers and strategies to overcome them

المؤلفون: Nicolas Joubert, Aubin Pitiot, Nathalie Heuzé-Vourc'h, Matthieu Gracia, Caroline Denevault-Sabourin, Timothée Blin, Thomas Sécher, Jean-Pierre Pouget, Juliette Lamamy, Sophie Poty, Valérie Gouilleux-Gruart, Débora Lanznaster, Yara Al Ojaimi

المساهمون: Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-...] (GICC EA 7501), Université de Tours (UT), Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut du Cancer de Montpellier (ICM), Le Pennec, Deborah, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours (UT)

المصدر: Pharmacology and Therapeutics
Pharmacology and Therapeutics, 2021, pp.108022. ⟨10.1016/j.pharmthera.2021.108022⟩
Pharmacology & Therapeutics
Pharmacology and Therapeutics, Elsevier, 2021, pp.108022. ⟨10.1016/j.pharmthera.2021.108022⟩

مصطلحات موضوعية: pI, isoelectric point, EU, European union, TNF, tumour necrosis factor, US, United States, Recombinant antibodies, Medicine, Pharmacology (medical), HER2, human epidermal growth factor receptor 2, Patient comfort, Target antigen, FcRn, neonatal Fc receptor, biology, GI, gastrointestinal, VEGF, vascular endothelial growth factor, ECM, extracellular matrix, IFP, interstitial fluid pressure, MMP, matrix metalloproteinase, Therapeutic strategies, Fab, fragment antigen-binding, RNA, Viral, AD, Alzheimer's disease, Antibody, 2019-20 coronavirus outbreak, medicine.medical_specialty, BBB, blood-brain barrier, IA, intra-articular, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), IgG, immunoglobulin G, CNS, central nervous system, ADC, antibody-drug conjugate, PK, pharmacokinetic, Antibodies, Therapeutic index, PD, pharmacodynamics, Biological barriers, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, IVIg, intravenous immunoglobulin, Humans, Immunologic Factors, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, mAb, monoclonal antibody, Intensive care medicine, Pandemics, Pharmacology, business.industry, SARS-CoV-2, IdeS, bacteria secreted proteases, scFv, single-chain variable fragment, Pathological barriers, Aβ, amyloid-β, FDA, Food and Drug Administration, COVID-19 Drug Treatment, Invited Article, biology.protein, Fc, fragment crystallizable, business, Site of action