نتائج البحث

المساهمون: Maiques-Diaz, Alba [0000-0002-3365-3775], Bloehdorn, Johannes [0000-0003-1433-9702], Moore, Andrew [0000-0002-2875-6315], Lu, Junyan [0000-0002-9211-0746], Moutsopoulos, Ilias [0000-0003-4584-7849], Zenz, Thorsten [0000-0001-7890-9845], Deaglio, Silvia [0000-0003-0632-5036], Hodson, Daniel J [0000-0001-6225-2033], Martin-Subero, Jose I [0000-0001-8809-5195], Ringshausen, Ingo [0000-0002-7247-311X], Apollo - University of Cambridge Repository, University of Zurich, Ringshausen, Ingo

وصف الملف: application/pdf; application/zip; text/xml; s41467_022_33739_2.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11899aea8fad9f4ca973b6120f75a29Test

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دورية أكاديمية

Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism.

المؤلفون: Duethorn, Binyamin, Groll, Fabian, Rieger, Bettina, Drexler, Hannes CA, Brinkmann, Heike, Kremer, Ludmila, Stehling, Martin, Borowski, Marie-Theres, Mildner, Karina, Zeuschner, Dagmar, Zernicka-Goetz, Magdalena, Stemmler, Marc P, Busch, Karin B, Vaquerizas, Juan M, Bedzhov, Ivan

مصطلحات موضوعية: Article, /631/136/2086, /631/80/313, /631/532/2064, /631/80/642/333/1465, /631/136/532/2064, /13, /13/100, /13/109, /14, /14/63, /38, /38/39, /38/77, /42, /64, /64/60, /82/58, /96/2, /96/31

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العلاقة: https://www.repository.cam.ac.uk/handle/1810/333513Test

الإتاحة: https://doi.org/10.17863/CAM.80933Test
https://www.repository.cam.ac.uk/handle/1810/333513Test

View record in BASE

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Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation

المساهمون: Kong, Li Ren [0000-0001-7980-4666], Tan, Tuan Zea [0000-0001-6624-1593], Kannan, Srinivasaraghavan [0000-0002-9539-5249], Lane, David P [0000-0003-0551-3545], Goh, Boon Cher [0000-0002-4107-102X], Apollo - University of Cambridge Repository, Lane, David P. [0000-0003-0551-3545]

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, 82/29, Mutant, 96, 45/44, General Physics and Astronomy, Apoptosis, Mice, SCID, 13, Hydroxamic Acids, 14, 96/31, Epigenesis, Genetic, 13/2, 13/1, chemistry.chemical_compound, 0302 clinical medicine, Neoplasms, Histone methylation, Protein Isoforms, 14/19, lcsh:Science, 13/89, Regulation of gene expression, 45/70, Sulfonamides, Multidisciplinary, biology, Caspase 3, Chemistry, 82/79, High-throughput screening, NF-kappa B, Acetylation, Chromatin, Ubiquitin ligase, Gene Expression Regulation, Neoplastic, 631/67/1059/602, Gain of Function Mutation, 030220 oncology & carcinogenesis, 38/39, 64/60, Poly(ADP-ribose) Polymerases, Protein Binding, 631/80/82/23, 101, Ubiquitin-Protein Ligases, Science, Antineoplastic Agents, 13/109, Models, Biological, Article, General Biochemistry, Genetics and Molecular Biology, 38, 03 medical and health sciences, Targeted therapies, Cell Line, Tumor, Animals, Humans, 96/1, Nucleotide Motifs, Codon, Cell Proliferation, 49/15, General Chemistry, DNA-binding domain, Xenograft Model Antitumor Assays, 49, 030104 developmental biology, 13/51, Mutation, biology.protein, Cancer research, lcsh:Q, Mutant Proteins, 631/154/1435/2163, Cisplatin, Tumor Suppressor Protein p53, Topotecan, DNA

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990d623049641fe5d64ca8c5af033a18Test
https://doaj.org/article/89ea4992ac4f465ea6d7ca0e0a05a0ddTest

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The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status

المساهمون: Trigg, Ricky M. [0000-0001-9329-9344], Martinez, Sonia [0000-0003-2230-7794], Blanco-Aparicio, Carmen [0000-0002-3249-6595], Kenner, Lukas [0000-0003-2184-1338], Turner, Suzanne D. [0000-0002-8439-4507], Apollo - University of Cambridge Repository, Trigg, Ricky M [0000-0001-9329-9344], Turner, Suzanne D [0000-0002-8439-4507], Children with Cancer UK, Cancer Research UK (Reino Unido), European Research Council

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Repisalud
Instituto de Salud Carlos III (ISCIII)

مصطلحات موضوعية: 0301 basic medicine, 82/29, 45/41, General Physics and Astronomy, Apoptosis, 45/47, 96/31, 13/2, 13/1, 38/1, 42/47, Mice, Neuroblastoma, 0302 clinical medicine, 42/89, hemic and lymphatic diseases, 38/23, 38/22, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, Sulfones, lcsh:Science, 13/89, N-Myc Proto-Oncogene Protein, Multidisciplinary, Chemistry, 45/77, 3. Good health, Biphenyl compound, 13/31, Cancer therapeutic resistance, 631/67/1059/602, 030220 oncology & carcinogenesis, 631/67/2332, Gene Knockdown Techniques, 38/77, Thiazolidines, 64/60, 631/67/70, 82/1, medicine.drug, Brigatinib, medicine.drug_class, 631/67/1059/2326, Science, 49/22, 49/23, PIM1, 38/90, 45/22, 13/106, 45/23, 13/109, General Biochemistry, Genetics and Molecular Biology, Article, 96/95, Paediatric cancer, 03 medical and health sciences, Targeted therapies, Organophosphorus Compounds, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, 38/89, medicine, Animals, Humans, 96/2, 96/1, Cancer models, Protein Kinase Inhibitors, 38/109, 96/106, Ceritinib, Biphenyl Compounds, General Chemistry, 64/110, medicine.disease, Xenograft Model Antitumor Assays, ALK inhibitor, 030104 developmental biology, Pyrimidines, Drug Resistance, Neoplasm, 13/51, 13/95, Cancer research, lcsh:Q, 82/51

وصف الملف: application/pdf; application/zip; text/xml; application/vnd.openxmlformats-officedocument.wordprocessingml.document

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced51d17bd4e3809b2cf33e72bf7a838Test
http://link.springer.com/article/10.1038/s41467-019-13315-xTest

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Characterisation of proguanylin expressing cells in the intestine – evidence for constitutive luminal secretion

المؤلفون: Claire L Meek, Geoffrey P. Roberts, Tristan J Vaughan, Richard G. Kay, Florent Serge Dye, Deborah A. Goldspink, Benjamin G. Challis, Pierre Larraufie, Maria A T Groves, Fiona M. Gribble, Frank Reimann, Franco Ferraro, Stephen J. Middleton, Juraj Rievaj, Richard H. Hardwick, Jennifer L. Percival-Alwyn, Tamana Darwish, Stephen O'Rahilly

المساهمون: Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge [UK] (CAM), O’Rahilly, Stephen [0000-0003-2199-4449], Reimann, Frank [0000-0001-9399-6377], Apollo - University of Cambridge Repository, O'Rahilly, Stephen [0000-0003-2199-4449]

المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-20 (2019)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-52049-0⟩

مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, Guanylin, lcsh:Medicine, 96/31, Article, 692/4020/198, 38/91, 96/95, Gastrointestinal Hormones, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, 692/163/2778, Organoid, medicine, Humans, Secretion, Intestinal Mucosa, Protein Precursors, Natriuretic Peptides, lcsh:Science, 14/35, Multidisciplinary, Ussing chamber, Chemistry, 82/58, lcsh:R, 64/110, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Golgi apparatus, Small intestine, 3. Good health, Cell biology, Transplantation, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, Preclinical research, 030220 oncology & carcinogenesis, 14/63, symbols, lcsh:Q, 82/1

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d3c9a4afb8d35913618034046ac232Test
http://link.springer.com/article/10.1038/s41598-019-52049-0Test

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MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

المساهمون: Clabbers, Max T B [0000-0002-5466-6508], Muusse, Timothy W [0000-0003-4384-5647], Malde, Alpeshkumar K [0000-0002-8181-1619], Nanson, Jeffrey D [0000-0003-1306-1948], Aquila, Andrew [0000-0003-0358-2774], Hunter, Mark S [0000-0002-0110-7075], Zhao, Jingjing [0000-0001-8444-6883], Zatsepin, Nadia A [0000-0003-1757-0205], Abbey, Brian [0000-0001-6504-0503], Sierecki, Emma [0000-0001-9970-868X], Darmanin, Connie [0000-0002-4449-2233], Kobe, Bostjan [0000-0001-9413-9166], Xu, Hongyi [0000-0002-8271-3906], Ve, Thomas [0000-0002-0113-1905], Apollo - University of Cambridge Repository, Clabbers, Max T. B. [0000-0002-5466-6508], Muusse, Timothy W. [0000-0003-4384-5647], Malde, Alpeshkumar K. [0000-0002-8181-1619], Nanson, Jeffrey D. [0000-0003-1306-1948], Hunter, Mark S. [0000-0002-0110-7075], Zatsepin, Nadia A. [0000-0003-1757-0205], Clabbers, Max TB [0000-0002-5466-6508]

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications 12(1), 2578 (2021). doi:10.1038/s41467-021-22590-6

مصطلحات موضوعية: Models, Molecular, Protein Conformation, alpha-Helical, 631/45/535, 631/535/1258/1259, Beta sheet, General Physics and Astronomy, 96/31, Biochemistry, Molecular dynamics, 0302 clinical medicine, Protein structure, Cryoelectron microscopy, General Materials Science, 0303 health sciences, Multidisciplinary, Membrane Glycoproteins, Crystallography, Nanocrystallography, hemic and immune systems, Condensed Matter Physics, Recombinant Proteins, 3. Good health, Electron diffraction, Femtosecond, lipids (amino acids, peptides, and proteins), ddc:500, 631/535/1266/1265, Structural biology, Dimerization, Signal Transduction, Materials science, 145, Science, Protein domain, Molecular Dynamics Simulation, digestive system, General Biochemistry, Genetics and Molecular Biology, Article, 96/95, 82/80, Inorganic Chemistry, 03 medical and health sciences, Protein Domains, parasitic diseases, Humans, Physical and Theoretical Chemistry, 82/83, 631/250/262/2106/2108, 030304 developmental biology, 101/28, Mutagenesis, Receptors, Interleukin-1, General Chemistry, biochemical phenomena, metabolism, and nutrition, Toll-like receptors, Toll-Like Receptor 4, HEK293 Cells, Mutation, Myeloid Differentiation Factor 88, Protein Conformation, beta-Strand, sense organs, 030217 neurology & neurosurgery

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