دورية أكاديمية
Isolation and Structural Determination of the First 8-epi-type Tetrodotoxin Analogs from the Newt, Cynops ensicauda popei, and Comparison of Tetrodotoxin Analogs Profiles of This Newt and the Puffer Fish, Fugu poecilonotus
| العنوان: | Isolation and Structural Determination of the First 8-epi-type Tetrodotoxin Analogs from the Newt, Cynops ensicauda popei, and Comparison of Tetrodotoxin Analogs Profiles of This Newt and the Puffer Fish, Fugu poecilonotus |
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| المؤلفون: | Yuta Kudo, Takeshi Yasumoto, Keiichi Konoki, Yuko Cho, Mari Yotsu-Yamashita |
| المصدر: | Marine Drugs; Volume 10; Issue 3; Pages: 655-667 |
| بيانات النشر: | Molecular Diversity Preservation International |
| سنة النشر: | 2012 |
| المجموعة: | MDPI Open Access Publishing |
| مصطلحات موضوعية: | tetrodotoxin, 8- epi -5,6,11-trideoxytetrodotoxin, puffer fish, newt, LC/MS |
| جغرافية الموضوع: | agris |
| الوصف: | Identification of new tetrodotoxin (TTX) analogs from TTX-possessing animals might provide insight into its biosynthesis and metabolism. In this study, four new analogs, 8-epi-5,6,11-trideoxyTTX, 4,9-anhydro-8-epi-5,6,11-trideoxyTTX, 1-hydroxy-8-epi-5,6,11-trideoxyTTX, and 1-hydroxy-4,4a-anhydro-8-epi-5,6,11-trideoxyTTX, were isolated from the newt, Cynops ensicauda popei, and their structures were determined using spectroscopic methods. These are the first 8-epi-type analogs of TTX that have been found in a natural source. Furthermore, we examined the composition of the TTX analogs in this newt and in the ovary of the puffer fish, Fugu poecilonotus, using LC/MS. The results indicate that TTX and 11-deoxyTTX were present in both sources. However, 6-epiTTX and 8-epi-type analogs were detected only in the newt, while 5,6,11-trideoxyTTX was a specific and major analog in the puffer fish. Such considerable differences among analog compositions might reflect differences in the biosynthesis or metabolism of TTX between these animals. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://dx.doi.org/10.3390/md10030655Test |
| DOI: | 10.3390/md10030655 |
| الإتاحة: | https://doi.org/10.3390/md10030655Test |
| حقوق: | https://creativecommons.org/licenses/by/3.0Test/ |
| رقم الانضمام: | edsbas.53458EB8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/md10030655 |
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