التفاصيل البيبلوغرافية
| العنوان: |
Defining Transcriptional Signatures of Human Hair Follicle Cell States |
| المؤلفون: |
Takahashi, Rie, Grzenda, Adrienne, Allison, Thomas F, Rawnsley, Jeffrey, Balin, Samuel J, Sabri, Shan, Plath, Kathrin, Lowry, William E |
| المصدر: |
Journal of Investigative Dermatology, vol 140, iss 4 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2020 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Immunology, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research - Nonembryonic - Human, Genetics, Underpinning research, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Aetiology, Skin, Animals, Cell Differentiation, Endothelial Cells, Hair Follicle, Humans, Stem Cells, Clinical Sciences, Oncology and Carcinogenesis, Dermatology & Venereal Diseases |
| جغرافية الموضوع: |
764 - 773.e4 |
| الوصف: |
The epidermis and its appendage, the hair follicle, represent an elegant developmental system in which cells are replenished with regularity because of controlled proliferation, lineage specification, and terminal differentiation. Although transcriptome data exists for human epidermal and dermal cells, the hair follicle remains poorly characterized. Through single-cell resolution profiling of the epidermis and anagen hair follicle, we characterized the anatomical, transcriptional, functional, and pathological profiles of distinct epidermal, hair follicle, and hair follicle-associated cell subpopulations including melanocytes, endothelial cells, and immune cells. We additionally traced the differentiation trajectory of interfollicular and matrix cell progenitors and explored the association of specific cell subpopulations to known molecular signatures of common skin conditions. These data simultaneously corroborate prior murine and human studies while offering new insights into epidermal and hair follicle differentiation and pathogenesis. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt4xg6h18t; https://escholarship.org/uc/item/4xg6h18tTest |
| الإتاحة: |
https://escholarship.org/uc/item/4xg6h18tTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.5CAA8E79 |
| قاعدة البيانات: |
BASE |
