-
1دورية أكاديمية
المؤلفون: Prevete I., Iuliano A., Cauli A., Piga M., Iannone F., Coladonato L., Bortoluzzi A., Silvagni E., Tani C., Elefante E., Doria A., Iaccarino L., Franceschini F., Fredi M., Conti F., Spinelli F. R., Frediani B., Garcìa E. G., Scirè C. A., Zanetti A., Rozza D., Carrara G., Sebastiani G. D.
المساهمون: Prevete, I., Iuliano, A., Cauli, A., Piga, M., Iannone, F., Coladonato, L., Bortoluzzi, A., Silvagni, E., Tani, C., Elefante, E., Doria, A., Iaccarino, L., Franceschini, F., Fredi, M., Conti, F., Spinelli, F. R., Frediani, B., Garcìa, E. G., Scirè, C. A., Zanetti, A., Rozza, D., Carrara, G., Sebastiani, G. D.
مصطلحات موضوعية: OBJECTIVES: Several studies show that age at onset has an impact on the clinical-serological presentation, comorbidities and disease course of patients with systemic lupus erythematosus (SLE). We evaluated whether, in patients with recent onset SLE, the age at onset correlates with clinical-serological manifestations and with comorbidities. METHODS: We analysed 171 patients with a SLE diagnosis obtained within 12 months of diagnosis enrolled in the Early Lupus project. Based on the age of onset of the first disease symptom, they were stratified into 2 groups: early onset (18–45 years) and late onset (>, 45 years). The analysis was replicated by stratifying patients based on age at diagnosis (fulfillment of ACR classification criteria). Each comparison was made at baseline and at 36 months of follow-up. RESULTS: Baseline: patients with late onset displayed comorbidities (hypertension, dyslipidemia and osteoporosis) more frequently than early onset group. 11.4% of late onset patients had a malignancy in medical history, not recorded in the early onset cohort. The two groups differed neither in organ involvement (domain BILAG) nor in disease activity (ECLAM). Patients with early onset showed a disease with signs of higher serologic activity (higher frequency of anti-dsDNA positivity and lower mean C3 and C4 levels) and had malar rash more frequently than the late onset group (36.2% vs. 18.2%, p=0.042). Similar results were obtained by stratifying patients by age of diagnosis (18-45 years and >, 45 years), except for the higher frequency of discoid rash in the group with age at diagnosis >, 45 years (18% vs. 6.6%, p=0.045). 36 months: the 2 groups of patients independently of the stratification applied did not differ in the accumulation of damage, but showed a different pattern of 8 organ involvement. Musculoskeletal involvement was more frequent both in the late onset group (18.6% vs. 7.3%, p=0.043) and in the group with age at diagnosis >, 45 years (20.4% vs. 5.9%, p=0.009) compared to their counterparts, while renal involvement was more frequent in the group with age at diagnosis 18–45 years (21.4% vs. 6.1%, p=0.03).A sub analysis at 36 months on patients without hypertension and osteoporosis at enrollment showed that patients with older age at onset had a higher frequency of these comorbidities, compared to their counterparts. CONCLUSIONS: In our cohort, younger disease SLE onset seems to correlate with a more active immunological profile, while late onset with a higher incidence of comorbidities.
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35894063; info:eu-repo/semantics/altIdentifier/wos/WOS:000955910000019; volume:41; issue:1; firstpage:145; lastpage:150; numberofpages:6; journal:CLINICAL AND EXPERIMENTAL RHEUMATOLOGY; https://hdl.handle.net/11584/367746Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85147047346; https://www.clinexprheumatol.org/abstract.asp?a=17991Test
الإتاحة: https://doi.org/10.55563/clinexprheumatol/oo5ymgTest
https://hdl.handle.net/11584/367746Test
https://www.clinexprheumatol.org/abstract.asp?a=17991Test -
2دورية أكاديمية
المؤلفون: Alex M. Silver, Leanne Elliott, Emily J. Braham, Heather J. Bachman, Elizabeth Votruba-Drzal, Catherine S. Tamis-LeMonda, Natasha Cabrera, Melissa E. Libertus
المصدر: Frontiers in Psychology, Vol 12 (2021)
مصطلحات موضوعية: number knowledge, math development, cardinal principle, remote data collection, toddlers aged 12 to 36 months, Psychology, BF1-990
وصف الملف: electronic resource
العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyg.2021.703598/fullTest; https://doaj.org/toc/1664-1078Test
-
3دورية أكاديمية
المؤلفون: Dionne V. Gootjes (11873472), Anke G. Posthumus (11873475), Vincent W. V. Jaddoe (7747976), Bas B. van Rijn (8538102), Eric A. P. Steegers (7827995)
مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Immunology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, total fat mass, systolic blood pressure, low platelet count, fat mass index, elevated liver enzymes, diastolic blood pressure, cardiometabolic risk factors, body mass index, pregnancy induced hypertension, generation rotterdam study, maternal hypertensive disorders, hypertensive disorders, hypertensive disorder,
%22">xlink ">, specific differences, ongoing population, confounder model, childhood triglyceride, 36 months, 28 sd, 15 sd, 10 ) -
4دورية أكاديمية
المؤلفون: Xiaolin Wei (287892), Zhitong Zhang (733339), Marc K. C. Chong (4370560), Joseph P. Hicks (3281682), Weiwei Gong (487252), Guanyang Zou (287895), Jieming Zhong (487251), John D. Walley (4370563), Ross E. G. Upshur (9292295), Min Yu (120607)
مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Immunology, Virology, 36- month follow-up, CVD risk, CVD events, cluster trial design, risk-based CVD prevention programmes, randomised 67 township hospitals, Trial registration ISRCTN registry ., health system factors, intervention arm, control arm, CVD surveillance system, control arms, type 2 diabetes, 10- year CVD risk, crude incidence rate ratio, CI, Main study limitations, outpatient drug costs, lifestyle interventions, hypertension, participant, 36 months
-
5دورية أكاديمية
المؤلفون: Xiaolin Wei (287892), Zhitong Zhang (733339), Marc K. C. Chong (4370560), Joseph P. Hicks (3281682), Weiwei Gong (487252), Guanyang Zou (287895), Jieming Zhong (487251), John D. Walley (4370563), Ross E. G. Upshur (9292295), Min Yu (120607)
مصطلحات موضوعية: Medicine, Cell Biology, Pharmacology, Biotechnology, Immunology, Virology, 36- month follow-up, CVD risk, CVD events, cluster trial design, risk-based CVD prevention programmes, randomised 67 township hospitals, Trial registration ISRCTN registry ., health system factors, intervention arm, control arm, CVD surveillance system, control arms, type 2 diabetes, 10- year CVD risk, crude incidence rate ratio, CI, Main study limitations, outpatient drug costs, lifestyle interventions, hypertension, participant, 36 months
-
6دورية أكاديمية
المؤلفون: Celine Miyazaki (3879907), Nagano Katsumasa (11154114), Kuan Chih Huang (11154117), Yan Fang Liu (1613593)
مصطلحات موضوعية: Medicine, Sociology, Cancer, Science Policy, Biological Sciences not elsewhere classified, HRU, burden, healthcare resource utilization, 12 months, SD, 36 months post-initiation, mirror image study
-
7دورية أكاديمية
المؤلفون: Celine Miyazaki (3879907), Nagano Katsumasa (11154114), Kuan Chih Huang (11154117), Yan Fang Liu (1613593)
مصطلحات موضوعية: Medicine, Sociology, Cancer, Science Policy, Biological Sciences not elsewhere classified, HRU, burden, healthcare resource utilization, 12 months, SD, 36 months post-initiation, mirror image study
العلاقة: https://figshare.com/articles/journal_contribution/Enteral_nutrition_procedures_/15016836Test
-
8دورية أكاديمية
المؤلفون: Celine Miyazaki (3879907), Nagano Katsumasa (11154114), Kuan Chih Huang (11154117), Yan Fang Liu (1613593)
مصطلحات موضوعية: Medicine, Sociology, Cancer, Science Policy, Biological Sciences not elsewhere classified, HRU, burden, healthcare resource utilization, 12 months, SD, 36 months post-initiation, mirror image study
-
9دورية أكاديمية
المؤلفون: Maria Gianniki (10011393), Tania Siahanidou (775766), Evanthia Botsa (10011396), Athanasios Michos (10011399)
مصطلحات موضوعية: Medicine, Biotechnology, Cancer, Science Policy, Infectious Diseases, Virology, Computational Biology, Greek origin, retrospective study, measles surveillance, care admission, measles vaccine, unvaccinated infant, laboratory characteristics, measles RNA, vaccinated populations, future measles outbreaks, emergency department, immunity gaps, Roma minority, measles cases, age 36 months, complications rates, Measles epidemic, vaccination coverage, study period, measles outbreak, Conclusion Measles, outcomes Background, 578 children
-
10دورية أكاديمية
المؤلفون: Polly Carmichael (10073634), Gary Butler (6205736), Una Masic (10073637), Tim J. Cole (7108901), Bianca L. De Stavola (10073640), Sarah Davidson (10073643), Elin M. Skageberg (10073646), Sophie Khadr (8279553), Russell M. Viner (7241537)
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Biotechnology, Cancer, Infectious Diseases, Virology, gender dysphoria, YSR self-harm indices, t-score, 24 months, bone mineral content, GD, BMC, BMD, UK, pubertal body changes, pubertal suppression, 12 months follow-up, CI, GnRHa, CBCL, bone mineral density, 36 months, Results 44 patients