دورية أكاديمية
Identification of serum microRNAs as potential diagnostic biomarkers for detecting precancerous lesions of gastric cancer
| العنوان: | Identification of serum microRNAs as potential diagnostic biomarkers for detecting precancerous lesions of gastric cancer |
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| المؤلفون: | Hajime Otsu, Sho Nambara, Qingjiang Hu, Yuichi Hisamatsu, Takeo Toshima, Kazuki Takeishi, Yusuke Yonemura, Takaaki Masuda, Eiji Oki, Koshi Mimori |
| المصدر: | Annals of Gastroenterological Surgery, Vol 7, Iss 1, Pp 63-70 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Surgery LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | 3‐dimensional microarray, gastric cancer, Kimura–Takemoto classification, miR‐196b, precancerous lesion, serum biomarker, Surgery, RD1-811, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Abstract Aim Gastric mucosal changes associated with chronic gastritis are known to be precancerous lesions of gastric cancer. We aimed to identify individuals with a high risk of gastric cancer by detection of microRNAs (miRNA) in the blood as biomarkers. Methods Of 1206 individuals screened, 144 who were positive for Helicobacter pylori (H. pylori) by the serum antibody test and who underwent endoscopy were the subjects of this study. For the gross assessment of mucosal inflammation, we applied the Kimura–Takemoto classification, in which normal mucosa was defined as grade 0, and atrophy was categorized as grade 1 (C‐1 and C‐2), grade 2 (C‐3 and O‐1), and grade 3 (O‐2 and O‐3). Serum samples were divided into two phases and used for miRNA microarray profiling. We compared the expression of miRNAs in grade 3 mucosa and other grades. Expression in gastric cancer was confirmed with TCGA data. Results miR‐196b‐3p was significantly upregulated, and miR‐92a‐2‐5p was downregulated (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2475-0328 |
| العلاقة: | https://doaj.org/toc/2475-0328Test |
| DOI: | 10.1002/ags3.12610 |
| الوصول الحر: | https://doaj.org/article/4f11a38643a540efbfb2d50c3270bee9Test |
| رقم الانضمام: | edsdoj.4f11a38643a540efbfb2d50c3270bee9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24750328 |
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| DOI: | 10.1002/ags3.12610 |