دورية أكاديمية
Integrating Post-Ionization Separation via Differential Mobility Spectrometry into Direct Analysis in Real Time Mass Spectrometry for Toy Safety Screening
| العنوان: | Integrating Post-Ionization Separation via Differential Mobility Spectrometry into Direct Analysis in Real Time Mass Spectrometry for Toy Safety Screening |
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| المؤلفون: | Mengmeng Yan, Nan Zhang, Xiaoxu Li, Jianqiang Xu, Haimin Lei, Qiang Ma |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Cell Biology, Inorganic Chemistry, Space Science, Chemical Sciences not elsewhere classified, various toy products, toy safety screening, primary aromatic amines, potentially hazardous chemicals, including bubble solutions, correlation coefficients greater, consumer health protection, achieving good linearity, 2 – 5, solid toy samples, enables direct desorption, differential mobility spectrometry, millisecond time scale, 11 paa analytes, compromised detection sensitivity, ms analysis enabled, satisfactory sensitivity, mass spectrometry, direct analysis, complex samples, sensitive analysis, real time, quantitation ranges, quantitation accuracy |
| الوصف: | Direct analysis in real time (DART) enables direct desorption and ionization of analytes, bypassing the time-consuming chromatographic separation traditionally required for mass spectrometry (MS) analysis. However, DART-MS suffers from matrix interference of complex samples, resulting in compromised detection sensitivity and quantitation accuracy. In this study, DART-MS was combined with differential mobility spectrometry (DMS) to provide an additional dimension of post-ionization ion mobility separation within a millisecond time scale, compensating for the lack of separation in DART-MS analysis. As proof-of-concept, primary aromatic amines (PAAs), a class of potentially hazardous chemicals, were analyzed in various toy products, including bubble solutions, finger paints, and plush toys. In addition to commercial Dip-it glass rod and metal mesh sampling tools, a customized rapid extractive evaporation device was designed for the accelerated extraction and sensitive analysis of solid toy samples. The incorporation of DMS in DART-MS analysis enabled the rapid separation and differentiation of isomeric analytes, leading to improved accuracy and reliability. The developed protocols were optimized and validated, achieving good linearity with correlation coefficients greater than 0.99 and acceptable repeatability with relative standard deviations less than 10%. Moreover, satisfactory sensitivity was realized with limits of detection and quantitation ranges of 0.2–5 and 1–20 μg/kg (μg/L) for the 11 PAA analytes. The established methodology was applied for the analysis of real toy samples ( n = 18), which confirmed its appealing potential for toy safety screening and consumer health protection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/Integrating_Post-Ionization_Separation_via_Differential_Mobility_Spectrometry_into_Direct_Analysis_in_Real_Time_Mass_Spectrometry_for_Toy_Safety_Screening/24913326Test |
| DOI: | 10.1021/acs.analchem.3c03915.s001 |
| الإتاحة: | https://doi.org/10.1021/acs.analchem.3c03915.s001Test https://figshare.com/articles/journal_contribution/Integrating_Post-Ionization_Separation_via_Differential_Mobility_Spectrometry_into_Direct_Analysis_in_Real_Time_Mass_Spectrometry_for_Toy_Safety_Screening/24913326Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.AD432B8C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.analchem.3c03915.s001 |
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