التفاصيل البيبلوغرافية
| العنوان: |
Csf metabolites associate with csf tau and improve prediction of alzheimer’s disease status |
| المؤلفون: |
Dong, R., Darst, B. F., Deming, Y., Ma, Y., Lu, Q., Zetterberg, Henrik, 1973, Blennow, Kaj, 1958, Carlsson, C. M., Johnson, S. C., Asthana, S., Engelman, C. D. |
| المصدر: |
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 13(1) |
| مصطلحات موضوعية: |
Neurosciences, Neurovetenskaper, Alzheimer’s disease, Cerebrospinal fluid, Metabolite, Metabolomics, P-tau, T-tau, 1 myristoyl 2 palmitoyl gpc, 1 oleoyl gpc, 1 palmitoyl gpc, arabinitol, arabinose, biological marker, C glycosyl tryptophan, glucuronic acid, gulonate, n acetylneuraminate, nucleotide derivative, pentose, tau protein, tryptophan, unclassified drug, x 10457, x 24228, xylitol, adult, aged, Alzheimer disease, Article, biological functions, clinical outcome, cognitive defect, cohort analysis, controlled study, female, glycerophospholipid metabolism, groups by age, human, major clinical study, male, middle aged, phospholipid metabolism, prediction, protein blood level, protein cerebrospinal fluid level, protein phosphorylation, sex difference, variance |
| الوصف: |
Introduction: Cerebrospinal fluid (CSF) total tau (t-tau) and phosphorylated tau (p-tau) are biomarkers of Alzheimer’s disease (AD), yet much is unknown about AD-associated changes in tau metabolism and tau tangle etiology. Methods: We assessed the variation of t-tau and p-tau explained by 38 previously identified CSF metabolites using linear regression models in middle-age controls from the Wisconsin Alzheimer’s Disease Research Center, and predicted AD/mild cognitive impairment (MCI) versus an independent set of older controls using metabolites selected by the least absolute shrinkage and selection operator (LASSO). Results: The 38 CSF metabolites explained 70.3% and 75.7% of the variance in t-tau and p-tau, respectively. Of these, seven LASSO-selected metabolites improved the prediction ability of AD/MCI versus older controls (area under the curve score increased from 0.92 to 0.97 and 0.78 to 0.93) compared to the base model. Discussion: These tau-correlated CSF metabolites increase AD/MCI prediction accuracy and may provide insight into tau tangle etiology. © 2021 The Authors. |
| الوصول الحر: |
https://gup.ub.gu.se/publication/306477Test |
| قاعدة البيانات: |
SwePub |
