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1رسالة جامعية
المؤلفون: 樊松嫚, FAN, SUNG-MAN
المساهمون: 心理學系
مصطلحات موضوعية: 高血壓、糖尿病與高膽固醇血症為常見血管風險因子，也為老年人中常見的慢性疾病。這些血管風險因子會引起血管構造的改變，常與動脈粥狀硬化、心臟疾病、中風等多種疾病共病，亦增加失智的風險。過去許多研究探討心血管風險因子與生活習慣如何導致失智症的發生，然而研究發現並不一致，不同的結果可能由於血管和生活習慣相關因素之間的複雜交互作用。此外，過去在不同人群的研究中，其結果的普遍性仍須進一步驗證。本研究目的為評估血管與生活習慣相關因素對於失智風險的預測。研究使用「秀傳醫療體系失智症登錄資料庫」，此資料庫提供長期追蹤且具回顧性的數據，從中選取無失智症並接受兩次檢查的參與者 (N = 1,285)。使用可控制共變量的Cox比例風險模型 (cox proportional hazard model)，評估血管和生活習慣相關因素對於失智、阿茲海默型失智 (dementia of the Alzheimer’s type, DAT)與血管型失智 (vascular dementia, VaD)風險之預測。控制共變量後，高膽固醇血症與降低失智及DAT風險相關，而茹素與高血壓則能正向預測VaD。此結果表明失智的臨床預測指標，未來以社區人口為樣本的研究中還需檢驗此結果的普遍性。, Hypertension, diabetes, and hypercholesterolemia are common diseases related to vascular risks in the elderly age. These diseases can cause changes in vascular structure, and are commonly comorbid with atherosclerosis, heart diseases and stroke. Furthermore, these vascular-related factors often increase the risk of dementia. Many previous studies have explored the predictive values of these vascular-related factors and lifestyle-related factors on incident dementia. However, the results are inconsistent. The inconsistent findings may be due to complex interactions among vascular- and lifestyle-related factors. In addition, the generalizability of findings in previous studies across different populations awaits further validation. The aim of this study is to estimate the risk of vascular- and lifestyle-related factors in predicting incident dementia. I used the History-based Artificial Intelligent Clinical Dementia Diagnosis System (HAICDDS) from Show Chwan Healthcare System, a retrospectively longitudinal database, to select participants without prevalent dementia and received two examinations (N = 1,285). Risks of incident all-cause dementia, dementia of the Alzheimer’s type (DAT), and vascular dementia (VaD) predicted by vascular- and lifestyle-related factors were assessed by using Cox proportional hazards regression models controlling covariates. Hypercholesterolemia was associated with decreased risks for incident all-cause dementia and DAT after controlling the covariates. Consuming vegetarian diets was associated with increased risk for incident all-caused dementia and VaD after controlling the covariates. These findings indicated clinically predictive markers for incident dementia. Future study in community is required to test the generalizability of the findings
وصف الملف: 102 bytes; text/html
العلاقة: http://asiair.asia.edu.tw/ir/handle/310904400/113663Test; http://asiair.asia.edu.tw/ir/bitstream/310904400/113663/1/index.htmlTest
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2دورية أكاديمية
المساهمون: 100044,北京大学人民医院心内科急性心肌梗死早期预警与干预北京市重点实验室北京大学人民医院心血管转化医学研究中心
المصدر: 万方 ; 知网 ; http://d.g.wanfangdata.com.cn/Periodical_zhlnxnxgbzz201705023.aspxTest
العلاقة: 中华老年心脑血管病杂志. 2017, 19(5), 541-544.; 1900864; http://hdl.handle.net/20.500.11897/467154Test
الإتاحة: https://doi.org/20.500.11897/467154Test
https://doi.org/10.3969/j.issn.1009-0126.2017.05.023Test
https://hdl.handle.net/20.500.11897/467154Test -
3دورية أكاديمية
المساهمون: 北京大学药学院,北京,100191, 北京大学医药管理国际研究中心,北京,100191, 四川大学华西医院,四川成都,610041, 福建医科大学第一附属医院,福建福州,350005, 北京大学药学院,北京 100191, 北京大学医药管理国际研究中心,北京 100191
المصدر: 万方 ; 知网 ; http://d.g.wanfangdata.com.cn/Periodical_zgywjjx201704003.aspxTest
العلاقة: 中国药物经济学. 2017, 12(4), 13-17.; 1901156; http://hdl.handle.net/20.500.11897/467434Test
الإتاحة: https://doi.org/20.500.11897/467434Test
https://doi.org/10.12010/j.issn.1673-5846.2017.04.003Test
https://hdl.handle.net/20.500.11897/467434Test -
4دورية أكاديمية
المساهمون: 100044,北京大学人民医院心内科
المصدر: 知网 ; 万方 ; http://d.g.wanfangdata.com.cn/Periodical_zhlnxnxgbzz201607030.aspxTest
العلاقة: 中华老年心脑血管病杂志.2016,18(7),780-782.; 1447705; http://hdl.handle.net/20.500.11897/494407Test
الإتاحة: https://doi.org/20.500.11897/494407Test
https://doi.org/10.3969/j.issn.1009-0126.2016.07.030Test
https://hdl.handle.net/20.500.11897/494407Test -
5مؤتمر
المساهمون: 北京大学医学部 心血管研究所 教育部分子心血管重点实验室,北京 100191
المصدر: 万方
مصطلحات موضوعية: Seipin 脂肪营养不良 高甘油三酯血症 高胆固醇血症 动脉粥样硬化
العلاقة: 2014北京大学心血管转化医学论坛论文集北京大学医学部;卫生部心血管分子生物学与调节肽重点实验室.; 1183593; http://hdl.handle.net/20.500.11897/331222Test
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المؤلفون: 古芝綺, Ku, Chih-Chi
المساهمون: 李以仁, Lee, I-Ren
مصطلحات موضوعية: 鈉離子依賴性膽酸轉運蛋白（ASBT）, 腸肝循環, 高膽固醇血症, 單分子螢光共振能量轉移, Apical sodium-dependent bile acid transporter(ASBT), enterohepatic circulation, hypercholesterolemia, single-molecule fluorescence resonance energy transfer(smFRET)
العلاقة: 60842098S-40073; https://etds.lib.ntnu.edu.tw/thesis/detail/32a990da59dbde5ff8af01ee4db46f40Test/; http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/117273Test
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7رسالة جامعية
المؤلفون: 黃衍彰, HUANG, YEN-CHANG
المساهمون: 心理學系
مصطلحات موضوعية: 文獻探討：隨人口老化趨勢，失智症的議題受到關注，早期偵測的意識也逐漸抬頭。大多探討心律不整與失智症的研究將關聯性歸因於心房纖維震顫(atrial fibrillation, AF)－心律不整中最常見的類型。心律不整還包含了其他的類型，且研究證明其他類型的心律不整和失智症之間也存在關聯。目前以亞洲樣本探討心律不整與失智症關聯性的研究較少，且過去台灣研究未將心律不整對於輕度認知缺損(mild cognitive impairment, MCI)患者納入研究當中進行討論。本研究探討台灣中南部地區，心律不整對MCI和失智症發生風險影響的預測。研究方法：本研究使用「秀傳醫療體系－失智症登錄資料庫」進行分析，以基線為認知正常與MCI參與者，且追蹤後認知狀態維持或惡化者進行分析，研究參與者共分為基線認知正常轉變為MCI或轉變為失智症，並考慮年齡效果，將MCI患者分為74歲以上與75歲以下患者共計四組。本研究透過羅吉斯迴歸，探討心律不整與其他變項對預測轉變發生的影響。研究結果：本研究中，基線認知正常組平均追蹤496.24 ± 274.93天，基線MCI組平均追蹤416.37 ± 218.84天。本研究中在75歲以上且基線MCI的參與者中，心律不整參與者失智症的風險較高。另外，高血壓和妄想症狀預測75歲以上MCI轉變為失智症，使用抗血脂藥物預測74歲以下MCI轉變為失智症，具有高膽固醇血症的75歲以上MCI以及服用抗高血壓藥物或具有易怒症狀的74歲以下MCI轉變為失智症的風險較低；焦慮症狀預測基線認知正常轉變MCI。討論與建議：本研究發現患有MCI，且有心律不整的75歲以上長者，轉變為失智症的風險較高，且另外發現血壓控制與總膽固醇含量對失智症的影響。可供臨床上健康照護參考，透過適當心律不整的控制與治療，以及心血管風險因子的管理，減少高齡長者轉變為失智症之風險程度。, Introduction: With the aging population growing, dementia is recognized as a global challenge. Studies have suggested early detecting of dementia in prodromal stages (i.e., mild cognitive impairment, MCI) in order to facilitate the early intervention for dementia. Recent studies have supported the relationship between arrhythmia and incident dementia, and often attribute the risk of arrhythmia and incident dementia to atrial fibrillation (AF), the most common type of arrhythmia. However, a recent large-scale study among elderly individuals in community revealed the other types of arrhythmia are also associated with incident dementia. The age effect is also observed between the risk of arrhythmia and incident dementia. There are less studies show the relationship between arrhythmia and incident dementia with Asian samples, and neither including the MCI samples. This study aimed to investigate the predictive values of arrhythmia and other modifiable factors in dementia on incident dementia between older (i.e., over 75 years old) and younger elderly individuals with low educational levels in Taiwan.Methods: The participants were selected from “Dementia registry database from Show Chwan Healthcare System”. This study included the participants with cognitive status normal and MCI in baseline and the cognitive status was stayed or deteriorated after followed. The participants were divided into four groups: baseline normal cognitive function (NC) convert to MCI, baseline NC to dementia, and older (i.e., older than 74 years) and younger (younger than 75 years) participants with baseline MCI convert to dementia. The MCI patients were separated according to age in order to investigate the modulating role of age on association between the modifiable factors and cognitive decline among MCI patients. This study showed the predictive models on incident dementia in four groups by logistic regression.Results: In this study, the mean duration follow-up of followed participant with baseline normal cognitive were 411.45 ± 224.42 days and the mean duration follow-up of followed participant with baseline MCI were 416.37 ± 218.84 days. The participants in baseline MCI over 75 years old have higher risk of incident dementia with arrhythmia than those without arrhythmia. Our study also found that hypertension and delusion are the risk factors of incident dementia in baseline MCI over 75 years old, the use of statins was a risk factor of incident dementia in baseline MCI under 74 years old, hypercholesterolemia was a protective factor for dementia among younger MCI patients, use of anti-hypertensives and symptom of irritability were risk factors among older MCI patients, and anxiety predicted the incident MCI in participants with baseline normal. Discussion: This study finds that the elder participants over 75 years old with baseline MCI and arrhythmia have increased the risk of incident dementia. Besides, the blood pressure and the total cholesterols are also the risk factors of incident dementia. This finding can be applied to the healthcare on older MCI patients with arrhythmia to decrease the risk of dementia by welling controlled and treatment on arrhythmia
وصف الملف: 102 bytes; text/html
العلاقة: http://asiair.asia.edu.tw/ir/handle/310904400/113664Test; http://asiair.asia.edu.tw/ir/bitstream/310904400/113664/1/index.htmlTest
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8دورية أكاديمية
المساهمون: 北京大学第一医院 老年内科,北京,100034, 北京市第二医院 心脑血管科,北京,100031
المصدر: 知网 ; 万方 ; http://d.g.wanfangdata.com.cn/Periodical_zgyxqyzz201505003.aspxTest
العلاقة: 中国医学前沿杂志（电子版）.2015,(5),4-6.; 1353830; http://hdl.handle.net/20.500.11897/426545Test
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9دورية أكاديمية
المؤلفون: 游凈惠(Ching-Hui You), 黃鈞源(Hwang, Juin-Yuen), 胡敏冰(Shiau-Ping Ow), 鍾昀志(Yun-Chih Chung), 黃麗卿(Lee-Ching Hwang)*
المساهمون: 臺北分院家醫科
العلاقة: 臺灣家庭醫學雜誌 (中華民國家庭醫學雜誌) 25(2):129-137; http://ir.cmu.edu.tw/ir/handle/310903500/55808Test; http://ir.cmu.edu.tw/ir/bitstream/310903500/55808/-1/BB-N820_20151112000900.docxTest
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10مؤتمر
المساهمون: 北京大学医学部心血管研究所, 教育部分子心血管重点实验室
المصدر: 知网
العلاقة: 国际心脏研究会（ISHR）中国分会（第十一届）暨中国病理生理学会心血管专业委员会（第十四届）、受体与信号转导专业委员会（第九届）学术会议.; 1020607; http://hdl.handle.net/20.500.11897/322902Test
