رسالة جامعية
紅茶水萃取物之防曬、護膚及染髮劑型之研究 ; The dosage form study of sunburn prevention,skin protection and hair dyeing with black tea aqueous extract
| العنوان: | 紅茶水萃取物之防曬、護膚及染髮劑型之研究 ; The dosage form study of sunburn prevention,skin protection and hair dyeing with black tea aqueous extract |
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| المؤلفون: | Yeh, Meng-I |
| سنة النشر: | 2013 |
| المجموعة: | Taipei Medical University Repository (TMUR) |
| مصطلحات موضوعية: | 紅茶水萃取物, 紫外線照射, 角質層, 高增生作用, 防曬劑, 微脂體, 通透作用, 非離子界面活性劑, 醇脂體, 穿皮傳遞, Black tea aqueous extract, Ultraviolet radiation, Keratinocytes, Hyperproliferation, Sunscreen, Niosome, Penetration, Non-ion surfactant, Ethosome, Transdermal delivery |
| الوصف: | 博士 指導教授-徐鳳麟 委員-廖嘉鴻 委員-李美賢 委員-歐耿良 委員-張永勳 委員-謝博軒 委員-林山陽 ; 本論文以紅茶水萃取物(BTE)發展安全的天然防曬劑。在動物實驗模式，BTE顯示可減少因紫外線過度曝曬所造成之傷害。於ICR小鼠的背部皮膚以含有1% BTE (2 mg/cm2或 20 mg/cm2) 乳膏前處理，將ICR小鼠分別以UVA (236.08 J/cm2)、UVB (118.04 J/cm2) 或 UVC (19.67 J/cm2) 照射。經過五天之後，ICR小鼠背部皮膚經含有1% BTE 20 mg/cm2乳膏前處理者，與控制組比較，顯示皮膚正常或僅呈現輕微紅腫、輕微脫皮結痂現象且不會出現皮膚角質層增生作用。這些結果證明1% BTE對於UVA、UVB和UVC的照射具明顯的保護作用。BTE將可作為天然的防曬劑，而且推測BTE的防曬效果可能來自其所含的主成分咖啡因(caffeine)和沒食子酸(gallic acid)。因此，本研究也探討使用niosomes作為體外傳遞BTE主成分caffeine 和 gallic acid之防曬劑微胞劑型，多層的niosomes劑型是以薄膜水合法所製成，並評估其以穿皮劑型做為護膚劑之可行性。結果顯示比起caffeine和gallic acid分散在水溶液之劑型，包埋caffeine和gallic acid的niosomes劑型於穿透皮膚膜的能力較高。因此，BTE之niosomes劑型具有做為防曬劑之潛力。另外利用ethosomal劑型，它是由非離子界面活性劑，水和高濃度之乙醇所組成。在體外實驗，包覆caffeine and gallic acid的 ethosome劑型 與BTE溶液進行比較，結果呈現，非離子ethosome劑型明顯促進BTE在毛髮表面的吸附作用。非離子ethosome劑型比BTE溶液有較多毛髮表面的傳遞及吸附效應。因而此劑型具有可發展成為毛髮染色劑及保護劑之可能性。 We try to use the black tea aqueous extract (BTE) to develop natural and safe sunscreen: In animal models, BTE exhibited provide remarkable protection that reduced the severity of adverse effects of overexposure to ultraviolet (UV) radiation. Skin of the dorsal areas of ICR mice were pretreated with cream containing 1% BTE(2 mg/cm2 or 20 mg/cm2), then ICR mice were then irradiated with either UVA (236.08 J/cm2), UVB (118.04 J/cm2), or UVC (19.67 J/cm2). After 5 days, the dorsal skin of mice pretreated with cream containing 1% BTE (20 mg/cm2) exhibited normal or slight erythema, slight scabbing and did not show hyperproliferation of keratinocytes compared to control animals. These results demonstrated that 1% BTE had a significant protective effect against irradiation with UVA, UVB, and UVC. BTE as a natural sunscreen agent and the sunscreen effect of the BTE may result from caffeine and gallic acid. The next study objective was to investigate the feasibility of using niosomes as a delivery vesicle for the dermal administration of BTE in vitro as a sunscreen. Multilamellar niosomes were obtained by means of a previously reported 'film' method. In vitro penetration experiments through nude mouse ... |
| نوع الوثيقة: | thesis |
| وصف الملف: | 183 bytes; text/html |
| اللغة: | Chinese |
| العلاقة: | http://libir.tmu.edu.tw/handle/987654321/54331Test; http://libir.tmu.edu.tw/bitstream/987654321/54331/2/index.htmlTest |
| الإتاحة: | http://libir.tmu.edu.tw/handle/987654321/54331Test http://libir.tmu.edu.tw/bitstream/987654321/54331/2/index.htmlTest |
| رقم الانضمام: | edsbas.89B66ADC |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |