دورية أكاديمية
Molecular genetic aspects of adrenocortical cancer ; Молекулярно-генетические аспекты адренокортикального рака
| العنوان: | Molecular genetic aspects of adrenocortical cancer ; Молекулярно-генетические аспекты адренокортикального рака |
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| المؤلفون: | D. P. Yashina, Z. A. Afanasyeva, Д. П. Яшина, З. А. Афанасьева |
| المساهمون: | Figure was partially generated using Servier Medical Art provided by Servier, licensed under a Creative Commons Attribution 3.0 non-ported license., В рисунках использованы элементы шаблонов Servier Medical Art, предоставленные компанией Servier с лицензией Creative Commons Attribution 3.0. |
| المصدر: | Advances in Molecular Oncology; Том 10, № 2 (2023); 42-57 ; Успехи молекулярной онкологии; Том 10, № 2 (2023); 42-57 ; 2413-3787 ; 2313-805X ; 10.17650/2313-805X-2023-10-2 |
| بيانات النشر: | “ABV-press” Publishing house”, LLC |
| سنة النشر: | 2023 |
| المجموعة: | Advances in molecular oncology (E-Journal) / Успехи молекулярной онкологии |
| مصطلحات موضوعية: | miRNA, adrenal ontogenesis, tumor transformation, signaling pathways, steroidogenic factor 1, Sonic Hedgehog, signaling pathways Wnt/β-catenin, signaling pathway SMAD, growth factors, insulin-like growth factor 2, transforming growth factor β, онтогенез надпочечников, опухолевая трансформация, сигнальные пути, стероидный фактор 1, сигнальный путь Wnt/β-катенин, сигнальный путь SMAD, факторы роста, инсулиноподобный фактор роста 2, трансформирующий фактор роста β |
| الوصف: | Adrenocortical cancer is a rare tumor originating from cortical adrenal cells, endowed with aggressive potential, a rapidly progressing course and an unfavorable prognosis. The complexity of early diagnosis of the disease is due to several factors: the variability of clinical manifestations associated with the initial multiregulatory influence of steroid hormones on the body’s homeostasis, the rare occurrence of the tumor and, as a result, the lack of understanding of the molecular mechanisms of its carcinogenesis.The increased interest in recent years among oncologists and endocrinologists in understanding the fundamental and clinical aspects of adrenocortical cancer and the search for potential targets for new drugs has led to a detailed study of the cellular and molecular genetic mechanisms involved in normal adrenal ontogenesis and their role in tumor transformation. This review presents the currently known molecular genetic processes and their mediating auto-, para-, endocrine factors involved in normal adrenal ontogenesis and carcinogenesis. The paper analyzes results of trials published in international and Russian journals on molecular oncology and endocrinology indexed in the PubMed, CyberLeninka, Web of Science, Science Direct and eLIBRARY databases. ; Адренокортикальный рак – редко встречаемая опухоль, происходящая из кортикальных клеток надпочечников, характеризующаяся агрессивным потенциалом, быстро прогрессирующим течением и неблагоприятным прогнозом. Сложность ранней диагностики заболевания обусловлена несколькими факторами: вариабельностью клинических проявлений, связанной с изначальным мультирегуляторным влиянием стероидных гормонов на гомеостаз организма, а также редкостью опухоли и, как следствие, малоизученностью молекулярных механизмов ее канцерогенеза. возросший за последние годы интерес онкологов и эндокринологов к пониманию фундаментальных и клинических аспектов адренокортикального рака и поиск потенциальных мишеней для новых лекарственных препаратов привели к детальному изучению ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Russian |
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| DOI: | 10.17650/2313-805X-2023-10-2-42-57 |
| الإتاحة: | https://doi.org/10.17650/2313-805X-2023-10-2-42-57Test https://doi.org/10.17650/2313-805X-2023-10-2Test https://doi.org/10.1210/er.2013-1029Test https://doi.org/10.1530/JME-18-0122Test https://doi.org/10.1210/me.2007-01204Test https://doi.org/10.4149/neo_2019_190105N17Test https://doi.org/10.3390/cancers12051218Test https://doi.org/10.3390/biomedicines9020174Test https://doi.org/10.1016/j.mce.2011.12.006Test https://doi.org/10.1016/j.ecl.2015.02.001Test |
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| رقم الانضمام: | edsbas.A3335F6F |
| قاعدة البيانات: | BASE |
| DOI: | 10.17650/2313-805X-2023-10-2-42-57 |
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