المؤلفون: de la Morena-Barrio, María Eugenia, Corral, Javier, López-García, Cecilia, Jiménez-Díaz, Víctor Alonso, Miñano, Antonia, Juan-Salvadores, Pablo, Esteve-Pastor, María Asunción, Baz-Alonso, José Antonio, Rubio, Ana María, Sarabia-Tirado, Francisco, García-Navarro, Miguel, García-Lara, Juan, Marín, Francisco, Vicente, Vicente, Pinar, Eduardo, Cánovas, Sergio José, de la Morena, Gonzalo

المساهمون: Sociedad Española de Cardiología, Fundación Séneca, Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares, Instituto de Salud Carlos III

المصدر: Frontiers in Cardiovascular Medicine ; volume 9 ; ISSN 2297-055X

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Background Aortic valve replacement is the gold standard treatment for severe symptomatic aortic stenosis, but thrombosis of bioprosthetic valves (PVT) remains a concern. Objective To analyze the factors involved in the contact pathway during aortic valve replacement and to assess their impact on the development of thromboembolic complications. Methods The study was conducted in 232 consecutive patients who underwent: transcatheter aortic valve replacement (TAVR, N = 155), and surgical valve replacement (SAVR, N = 77) (MUVITAVI project). Demographic and clinical data, outcomes including a combined end point (CEP) of thrombotic events, and imaging controls were recruited. Samples were collected 24 h before and 48 h after valve replacement. FXII, FXI and (pre)kallikrein were evaluated by Western Blot and specific ELISA with nanobodies. Results The CEP of thrombotic events was reached by 19 patients: 13 patients presented systemic embolic events and 6 patients subclinical PVT. Valve replacement did not cause FXII activation or generation of kallikrein. There was a significant reduction of FXI levels associated with the procedure, which was statistically more pronounced in SAVR than in TAVR. Cases with reductions of FXI below 80% of basal values had a lower incidence of embolic events during the procedure than patients in whom FXI increased above 150%: 2.7 vs. 16.7%; p : 0.04. Conclusion TAVR or SAVR did not significantly activate the contact pathway. A significant reduction of FXI, was observed, particularly in SAVR, associated with lower incidence of thrombotic events. These results encourage evaluating the usefulness and safety of FXI-directed antithrombotic treatments in these patients.

الإتاحة: https://doi.org/10.3389/fcvm.2022.887664Test

المؤلفون: Arribas, José María, Rivera-Caravaca, José Miguel, Moreno, Jose A., Aranda, Ramón, Masso, Javier, Jiménez, Antonio, Pérez-Andreu, Joaquín, Taboada, Rubén, Fernández, Manuel, Aguilar, Juan M., García-Puente, Julio J., Lorenzo, Maydelin, Gutiérrez, Francisco, de la Morena, Gonzalo, Jara, Rubén, Cánovas, Sergio J.

المصدر: Cirugía Cardiovascular ; volume 28, issue 2, page 77-83 ; ISSN 1134-0096

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.circv.2020.08.002Test
https://api.elsevier.com/content/article/PII:S1134009620302047?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1134009620302047?httpAccept=text/plainTest

المؤلفون: Manganaro, Roberta, MARCHETTA, Stella, DULGHERU, Raluca Elena, Sugimoto, Tadafumi, Tsugu, Toshimitsu, Ilardi, Federica, Cicenia, Marianna, ANCION, Arnaud, Postolache, Adriana, Martinez, Christophe, Kacharava, George, Athanassopoulos, George D., Barone, Daniele, Baroni, Monica, Cardim, Nuno, Hagendorff, Andreas, Hristova, Krasimira, Lopez, Teresa, de la Morena, Gonzalo, Popescu, Bogdan A., Penicka, Martin, Ozyigit, Tolga, Rodrigo Carbonero, Jose David, van de Veire, Nico, Von Bardeleben, Ralph Stephan, Vinereanu, Dragos, Zamorano, Jose Luis, Rosca, Monica, Calin, Andreea, Moonen, Marie, Magne, Julien, Cosyns, Bernard, Galli, Elena, Donal, Erwan, Carerj, Scipione, Zito, Concetta, Santoro, Ciro, Galderisi, Maurizio, Badano, Luigi P., Lang, Roberto M., Lancellotti, Patrizio

المصدر: European Heart Journal. Cardiovascular Imaging, 21, 533-541 (2020-05)

مصطلحات موضوعية: adult echocardiography, myocardial strain, myocardial work, speckle tracking echocardiography, Human health sciences, Cardiovascular & respiratory systems, Sciences de la santé humaine, Systèmes cardiovasculaire & respiratoire

الوصف: peer reviewed ; AIMS: The present study sought to evaluate the correlation between indices of non-invasive myocardial work (MW) and left ventricle (LV) size, traditional and advanced parameters of LV systolic and diastolic function by 2D echocardiography (2DE). METHODS AND RESULTS: A total of 226 (85 men, mean age: 45 +/- 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from LV pressure-strain loops using custom software. Peak LV pressure was estimated non-invasively from brachial artery cuff pressure. LV size, parameters of systolic and diastolic function and ventricular-arterial coupling were measured by echocardiography. As advanced indices of myocardial performance, global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) were obtained. On multivariable analysis, GWI was significantly correlated with GLS (standardized beta-coefficient = -0.23, P < 0.001), ejection fraction (EF) (standardized beta-coefficient = 0.15, P = 0.02), systolic blood pressure (SBP) (standardized beta-coefficient = 0.56, P < 0.001) and GRS (standardized beta-coefficient = 0.19, P = 0.004), while GCW was correlated with GLS (standardized beta-coefficient = -0.55, P < 0.001), SBP (standardized beta-coefficient = 0.71, P < 0.001), GRS (standardized beta-coefficient = 0.11, P = 0.02), and GCS (standardized beta-coefficient = -0.10, P = 0.01). GWE was directly correlated with EF and inversely correlated with Tei index (standardized beta-coefficient = 0.18, P = 0.009 and standardized beta-coefficient = -0.20, P = 0.004, respectively), the opposite occurred for GWW (standardized beta-coefficient =--0.14, P = 0.03 and standardized beta-coefficient = 0.17, P = 0.01, respectively). CONCLUSION: The non-invasive MW indices show a good correlation with traditional 2DE ...

العلاقة: urn:issn:2047-2404; urn:issn:2047-2412; https://orbi.uliege.be/handle/2268/248109Test; info:hdl:2268/248109; https://orbi.uliege.be/bitstream/2268/248109/1/jez203.pdfTest; scopus-id:2-s2.0-85083913496; info:pmid:31408147

الإتاحة: https://doi.org/10.1093/ehjci/jez203Test
https://orbi.uliege.be/handle/2268/248109Test
https://orbi.uliege.be/bitstream/2268/248109/1/jez203.pdfTest

المؤلفون: Tsugu, Toshimitsu, Postolache, Adriana, DULGHERU, Raluca Elena, Sugimoto, Tadafumi, TRIDETTI, Julien, NGUYEN TRUNG, Mai-Linh, PIETTE, Caroline, MOONEN, Marie, Manganaro, Roberta, Ilardi, Federica, Chitroceanu, Alexandra Maria, Sperlongano, Simona, Go, Yun Yun, Kacharava, George, Athanassopoulos, George D., Barone, Daniele, Baroni, Monica, Cardim, Nuno, Hagendorff, Andreas, Hristova, Krasimira, Lopez, Teresa, de la Morena, Gonzalo, Popescu, Bogdan A., Penicka, Martin, Ozyigit, Tolga, Rodrigo Carbonero, Jose David, van de Veire, Nico, Von Bardeleben, Ralph Stephan, Vinereanu, Dragos, Zamorano, Jose Luis, Rosca, Monica, Calin, Andreea, Magne, Julien, Cosyns, Bernard, Galli, Elena, Donal, Erwan, Santoro, Ciro, Galderisi, Maurizio, Badano, Luigi P., Lang, Roberto M., Lancellotti, Patrizio

المصدر: European Heart Journal. Cardiovascular Imaging (2020)

مصطلحات موضوعية: 2D echocardiography, adult echocardiography, deformation imaging, reference values, Human health sciences, Cardiovascular & respiratory systems, Sciences de la santé humaine, Systèmes cardiovasculaire & respiratoire

الوصف: peer reviewed ; AIMS : To obtain the normal range for 2D echocardiographic (2DE) measurements of left ventricular (LV) layer-specific strain from a large group of healthy volunteers of both genders over a wide range of ages. METHODS AND RESULTS : A total of 287 (109 men, mean age: 46 +/- 14 years) healthy subjects were enrolled at 22 collaborating institutions of the EACVI Normal Reference Ranges for Echocardiography (NORRE) study. Layer-specific strain was analysed from the apical two-, three-, and four-chamber views using 2DE software. The lowest values of layer-specific strain calculated as +/-1.96 standard deviations from the mean were -15.0% in men and -15.6% in women for epicardial strain, -16.8% and -17.7% for mid-myocardial strain, and -18.7% and -19.9% for endocardial strain, respectively. Basal-epicardial and mid-myocardial strain decreased with age in women (epicardial; P = 0.008, mid-myocardial; P = 0.003) and correlated with age (epicardial; r = -0.20, P = 0.007, mid-myocardial; r = -0.21, P = 0.006, endocardial; r = -0.23, P = 0.002), whereas apical-epicardial, mid-myocardial strain increased with the age in women (epicardial; P = 0.006, mid-myocardial; P = 0.03) and correlated with age (epicardial; r = 0.16, P = 0.04). End/Epi ratio at the apex was higher than at the middle and basal levels of LV in men (apex; 1.6 +/- 0.2, middle; 1.2 +/- 0.1, base 1.1 +/- 0.1) and women (apex; 1.6 +/- 0.1, middle; 1.1 +/- 0.1, base 1.2 +/- 0.1). CONCLUSION : The NORRE study provides useful 2DE reference ranges for novel indices of layer-specific strain.

العلاقة: urn:issn:2047-2404; urn:issn:2047-2412; https://orbi.uliege.be/handle/2268/249469Test; info:hdl:2268/249469; https://orbi.uliege.be/bitstream/2268/249469/1/Echocardiographic%20reference%20ranges%20for%20normal%20left%20ventricular%20layer-specific%20strain-%20results%20from%20the%20EACVI%20NORRE%20study.pdfTest; scopus-id:2-s2.0-85088494543; info:pmid:32259844

الإتاحة: https://doi.org/10.1093/ehjci/jeaa050Test
https://orbi.uliege.be/handle/2268/249469Test
https://orbi.uliege.be/bitstream/2268/249469/1/Echocardiographic%20reference%20ranges%20for%20normal%20left%20ventricular%20layer-specific%20strain-%20results%20from%20the%20EACVI%20NORRE%20study.pdfTest

المؤلفون: Escribano, Javier Pagán, Navarro, Alejandro Lova, de la Morena, Gonzalo, Vázquez, David José, Manchado, Juan José Cerezo, Pérez, Carlos Bravo, de la Calle, Javier Corral, Barrio, Maria Eugenia de la Morena

المصدر: Revista Clínica Española ; volume 223, page S935-S937 ; ISSN 0014-2565

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/s0014-2565Test(23)01139-6
https://api.elsevier.com/content/article/PII:S0014256523011396?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0014256523011396?httpAccept=text/plainTest

المؤلفون: Lova, Alejandro, Pagán, Javier, de la Morena, Gonzalo, Vázquez, David José, Cerezo-Manchado, Juan José, Bravo-Pérez, Carlos, Miñano, Antonia, Tomás, Ana, Vicente, Vicente, Lozano, María Luisa, Corral, Javier, de la Morena-Barrio, María Eugenia

المصدر: Journal of Thrombosis and Haemostasis ; volume 21, issue 9, page 2626-2629 ; ISSN 1538-7836

مصطلحات موضوعية: Hematology

الإتاحة: https://doi.org/10.1016/j.jtha.2023.06.013Test
https://api.elsevier.com/content/article/PII:S153878362300497X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S153878362300497X?httpAccept=text/plainTest

المؤلفون: Moral, Sergio, Abulí, Marc, Méndez, Irene, González-Gómez, Ariana, García-Quintana, Antonio, Menduiña, Irene, Payá, Rafael, Esteban, Esther, Sánchez, Pedro Luis, Díaz, Elena, de la Morena, Gonzalo, Calvo-Iglesias, Franciso, Gallego, Pastora, Ballesteros, Esther, Brugada, Ramon, Evangelista, Arturo

المصدر: International Journal of Cardiology ; volume 375, page 66-73 ; ISSN 0167-5273

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.ijcard.2023.01.005Test
https://api.elsevier.com/content/article/PII:S0167527323000487?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0167527323000487?httpAccept=text/plainTest

المؤلفون: Manganaro, Roberta, MARCHETTA, Stella, Dulgheru, Raluca Elena, Ilardi, Federica, Sugimoto, Tadafumi, ROBINET, Sébastien, Cimino, Sara, Go, Yun Yun, Bernard, Anne, Kacharava, George, Athanassopoulos, George, Barone, Daniele, Baroni, Monica, Cardim, Nuno, Hagendorff, Andreas, Hristova, Krasimira, Lopez-Fernandez, Teresa, de la Morena, Gonzalo, Popescu, Bogdan Alexandru, Penicka, Martin, Ozyigit, Tolga, Rodrigo Carbonero, Jose David, van de Veire, Nico, Von Bardeleben, Ralph Stephan, Vinereanu, Dragos, Zamorano, Jose Luis, Rosca, Monica, Calin, Andreea, Moonen, Marie, Magne, Julien, Cosyns, Bernard, Galli, Elena, Donal, Erwan, Carerj, Scipione, Zito, Concetta, Santoro, Ciro, Galderisi, Maurizio, Badano, Luigi P., Lang, Roberto M., Oury, Cécile, Lancellotti, Patrizio

المصدر: European Heart Journal. Cardiovascular Imaging (2019)

مصطلحات موضوعية: Human health sciences, Cardiovascular & respiratory systems, Sciences de la santé humaine, Systèmes cardiovasculaire & respiratoire

الوصف: peer reviewed ; Aims: To obtain the normal ranges for 2D echocardiographic (2DE) indices of myocardial work (MW) from a large group of healthy volunteers over a wide range of ages and gender. Methods and results: A total of 226 (85 men, mean age: 45 +/- 13 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. Global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE) were estimated from left ventricle (LV) pressure-strain loops. Peak LV systolic pressure was non-invasively derived from brachial artery cuff pressure. The lowest values of MW indices in men and women were 1270 mmHg% and 1310 mmHg% for GWI, 1650 mmHg% and 1544 mmHg% for GCW, and 90% and 91% for GWE, respectively. The highest value for GWW was 238 mmHg% in men and 239 mmHg% in women. Men had significant lower values of GWE and higher values of GWW. GWI and GCW significantly increased with age in women. Conclusion: The NORRE study provides useful 2DE reference ranges for novel indices of non-invasive MW.

العلاقة: urn:issn:2047-2404; urn:issn:2047-2412; https://orbi.uliege.be/handle/2268/231043Test; info:hdl:2268/231043; https://orbi.uliege.be/bitstream/2268/231043/1/Manganaro%20et%20al%20EHJ_Cardiovasc%20Imaging%202018.pdfTest; scopus-id:2-s2.0-85068205398; info:pmid:30590562

الإتاحة: https://doi.org/10.1093/ehjci/jey188Test
https://orbi.uliege.be/handle/2268/231043Test
https://orbi.uliege.be/bitstream/2268/231043/1/Manganaro%20et%20al%20EHJ_Cardiovasc%20Imaging%202018.pdfTest

المؤلفون: Hernández-Romero, Diana, Sánchez-Quiñones, Jessica, Vílchez, Juan Antonio, Rivera-Caravaca, José Miguel, de la Morena, Gonzalo, Lip, Gregory Y H, Climent, Vicente, Marín, Francisco

المصدر: Hernández-Romero , D , Sánchez-Quiñones , J , Vílchez , J A , Rivera-Caravaca , J M , de la Morena , G , Lip , G Y H , Climent , V & Marín , F 2019 , ' Galectin-3 and β-trace protein concentrations are higher in clinically unaffected patients with Fabry disease ' , Scientific Reports , vol. 9 , no. 1 , 6235 . https://doi.org/10.1038/s41598-019-42727-4Test

الوصف: Current therapies have not shown benefit in organ damage reversal in Fabry disease (FD), but biomarkers could help risk stratification and prognosis. We investigated if several biomarkers of cardiac fibrosis, cardiac wall stress, myocardial injury, renal function and inflammation, are associated with early cardiac affectation in FD patients. We included FD patients from four cardiology outpatient clinics of southeastern Spain. At inclusion, Galectin-3 (Gal-3), N-terminal proB-type natriuretic peptide, high sensitivity troponin T (hsTnT), β-trace protein (BTP) and interleukin-6 concentrations were measured. The relation of biomarkers concentrations with clinical features, cardiac involvement and organ affectation according to the Mainz Severity Score Index (MSSI) was investigated. 44 FD patients (n = 21 affected and n = 23 unaffected) were compared to age and sex-respectively matched healthy controls. Significant differences in biomarkers' concentration between FD groups were observed. Importantly, Gal-3 and BTP levels were higher in unaffected patients when compared with age and sex-matched healthy controls (both p < 0.05). All the biomarkers correlated with clinical features. When cut-off values for clinical affectation (measured as MSSI ≥ 20) were established, only hsTnT (OR 30.69, 95% CI 2.70-348.42) and male sex (OR 8.17, 95% CI 1.16-57.75) were independently associated with cardiac damage by multivariate regression analysis. Gal-3 and BTP levels are increased in unaffected FD patients compared to healthy controls. This suggests that these biomarkers could be useful for the early detection of cardiac affectation in FD patients. On the other hand, hsTnT and male sex are independent risk factors for established clinical cardiac damage in FD.

وصف الملف: application/pdf

العلاقة: https://vbn.aau.dk/da/publications/9b02719c-82d8-42ba-ae36-ad8c064a517aTest

الإتاحة: https://doi.org/10.1038/s41598-019-42727-4Test
https://vbn.aau.dk/da/publications/9b02719c-82d8-42ba-ae36-ad8c064a517aTest
https://vbn.aau.dk/ws/files/302245951/s41598_019_42727_4.pdfTest
http://www.scopus.com/inward/record.url?scp=85064542404&partnerID=8YFLogxKTest

المؤلفون: Sugimoto, Tadafumi, ROBINET, Sébastien, DULGHERU, Raluca Elena, Bernard, Anne, Ilardi, Federica, Contu, Laura, Addetia, Karima, Caballero, Luis, Kacharava, George, Athanassopoulos, George, Barone, Daniele, Baroni, Monica, Cardim, Nuno, Hagendorff, Andreas, Hristova, Krasimira, Lopez, Teresa, de la Morena, Gonzalo, Popescu, Bogdan Alexandru, Penicka, Martin, Ozyigit, Tolga, Rodrigo Carbonero, Jose David, van de Veire, Nico, Von Bardeleben, Ralph Stephan, Vinereanu, Dragos, Zamorano, Jose Luis, Go, Yun Yun, MARCHETTA, Stella, Nchimi Longang, Alain, Rosca, Monica, Calin, Andreea, MOONEN, Marie, Cimino, Sara, Magne, Julien, Cosyns, Bernard, Galli, Elena, Donal, Erwan, Habib, Gilbert, Esposito, Roberta, Galderisi, Maurizio, Badano, Luigi P., Lang, Roberto M., Lancellotti, Patrizio

المصدر: European Heart Journal. Cardiovascular Imaging, 19 (6), 630-638 (2018)

مصطلحات موضوعية: Human health sciences, Cardiovascular & respiratory systems, Sciences de la santé humaine, Systèmes cardiovasculaire & respiratoire

الوصف: peer reviewed ; Aims: To obtain the normal ranges for echocardiographic measurements of left atrial (LA) function from a large group of healthy volunteers accounting for age and gender. Methods and results: A total of 371 (median age 45 years) healthy subjects were enrolled at 22 collaborating institutions collaborating in the Normal Reference Ranges for Echocardiography (NORRE) study of the European Association of Cardiovascular Imaging (EACVI). Left atrial data sets were analysed with a vendor-independent software (VIS) package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire data sets. The lowest expected values of LA function were 26.1%, 48.7%, and 41.4% for left atrial strain (LAS), 2D left atrial emptying fraction (LAEF), and 3D LAEF (reservoir function); 7.7%, 24.2%, and -0.53/s for LAS-active, LAEF-active, and LA strain rate during LA contraction (SRa) (pump function) and 12.0% and 21.6% for LAS-passive and LAEF-passive (conduit function). Left atrial reservoir and conduit function were decreased with age while pump function was increased. All indices of reservoir function and all LA strains had no difference in both gender and vendor. However, inter-vendor differences were observed in LA SRa despite the use of VIS. Conclusion: The NORRE study provides contemporary, applicable echocardiographic reference ranges for LA function. Our data highlight the importance of age-specific reference values for LA functions.

العلاقة: urn:issn:2047-2404; urn:issn:2047-2412; https://orbi.uliege.be/handle/2268/229247Test; info:hdl:2268/229247; https://orbi.uliege.be/bitstream/2268/229247/1/NORRE.pdfTest; scopus-id:2-s2.0-85048197377; info:pmid:29529180

الإتاحة: https://doi.org/10.1093/ehjci/jey018Test
https://orbi.uliege.be/handle/2268/229247Test
https://orbi.uliege.be/bitstream/2268/229247/1/NORRE.pdfTest