المؤلفون: Siyan ZHONG, Bo ZOU, Jinbo LIN, Manqin FU, Jijun WU, Yuanshan YU, Xiaowei CHEN, Yujuan XU

المصدر: Shipin gongye ke-ji, Vol 45, Iss 14, Pp 253-263 (2024)

مصطلحات موضوعية: wampee, fruit quality, antioxidant, principal component analysis (pca), cluster analysis, Food processing and manufacture, TP368-456

الوصف: In order to study the differences in the comprehensive quality and processing characteristics of different varieties of wampee (Clausena lansium (Lour.) Skeels), seven kinds of wampee ('Bingtanghuangpi' 'Jixinhuangpi' 'Jinhuangpi' 'Guifeisanhao' 'Baimihuangpi' 'Huananyihao' 'Wuhehuangpi') were taken as the research objects, the physical property, chemical composition and antioxidant capacity of the fruits were analyzed, and the processing characteristics of the seven kinds of wampee were evaluated and categorized using principal component analysis and cluster analysis. The results showed that the pulping rate, soluble sugar and organic acid content of seven kinds of wampee ranged from 50.51% to 60.71%, 18.93 to 48.91 mg/g and 8.13 to 14.00 mg/g. Respectively, the 'Bingtanghuangpi' had the highest pulping rate, the 'Baimihuangpi' had the highest soluble sugar content, the 'Jixinhuangpi' had the highest organic acid content. The total phenol content of pericarp, total phenol content of fruit pulp, total flavonoid content of pericarp and total flavonoid content of fruit pulp ranged from 2446.4 to 4045.5 mg/kg DW, 763.7 to 118.2 mg/kg, 234.1 to 678.7 mg/kg DW, and 96.8 to 143.4 mg/kg. Respectively, the 'Guifeisanhao' had the highest total phenolic and total flavonoid content, and the strongest antioxidant capacity (ferric reducing antioxidant power (FRAP), DPPH radical scavenging capacity). Nine phenolic compounds in wampee were identified by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), and rutin was the main phenolic compound. The results of principal component analysis showed that 25 indicators reflecting the quality of different varieties of wampee, that can be expressed by four principal components (the cumulative contribution rate reached 87.51%), of which 'Guifeisanhao' scored the highest in the comprehensive evaluation of principal component analysis, and 'Bingtanghuangpi' scored the lowest. The results of cluster analysis were basically consistent with the results of principal component analysis. Overall, 'Guifeisanhao' and 'Wuhehuangpi' had the highest content of total phenolics, total flavonoids and the strongest antioxidant ability, but the soluble sugar content was relatively low, which was more suitable for the extraction of active substances. 'Bingtanghuangpi' and 'Baimihuangpi' had high soluble sugar content and low organic acid content, with moderate sweet and sour taste, which was suitable for fresh food, and the high organic acid content of 'Jinhuangpi' 'Huananyihao' and 'Jixinhuangpi' was more suitable for processing into food ingredient.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1002-0306Test

الوصول الحر: https://doaj.org/article/893818ada0f643cca1da4ae4ac68abb8Test

المؤلفون: Tianyu Zhou, Chongze Chen, Xiaowei Chen, Bin Wang, Feng Sun, Wanfang Li, Dong Liu, Hongtao Jin

المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract Azole antifungal drugs are commonly used to treat vulvovaginal candidiasis (VVC). The nephrotoxicity and developmental toxicity of azole drugs have not been systematically analyzed in the real world. We used the FDA Adverse Event Reporting System (FAERS) to investigate the adverse events (AEs) associated with imidazole therapy for VVC. FAERS data (from quarter 1 2004 to quarter 3 2022) were retrieved using OpenVigil 2.1, and AEs were retrieved and standardized according to the Medical Dictionary for Regulatory Activities (MedDRA). In the top 10 System Organ Class (SOC), all four drugs have been found to have kidney and urinary system diseases and pregnancy. We found significant signals, including clotrimazole [bladder transitional cell carcinoma, (report odds ratio, ROR = 291.66)], [fetal death, (ROR = 10.28)], ketoconazole[nephrogenic anemia (ROR = 22.1)], [premature rupture of membranes (ROR = 22.91 46.45, 11, 3)], Miconazole[hematuria (ROR = 19.03)], [neonatal sepsis (ROR = 123.71)], [spontaneous abortion (ROR = 5.98)], Econazole [acute kidney injury (ROR = 4.41)], [spontaneous abortion (ROR = 19.62)]. We also discovered new adverse reactions that were not reported. Therefore, when using imidazole drugs for treatment, it is necessary to closely monitor the patient's renal function, pay attention to the developmental toxicity of the fetus during pregnancy, and be aware of potential adverse reactions that may occur.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/18b202a94df1495cbcb33470fd859a15Test

المؤلفون: Nana Guo, Qingxin Zhou, Meng Zhang, Xiaowei Chen, Baoqi Zeng, Shanshan Wu, Hongmei Zeng, Mopei Wang, Fei Ma, Feng Sun

المصدر: Journal of the National Cancer Center, Vol 4, Iss 2, Pp 153-161 (2024)

مصطلحات موضوعية: ctDNA, Breast cancer, Molecular subtype, RFS, OS, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Objective: Circulating tumor DNA (ctDNA) is increasingly being used as a potential prognostic biomarker in cancer patients. We aimed to assess the prognostic value of ctDNA in different subtypes of breast cancer patients throughout the whole treatment cycle. Materials and methods: PubMed, Web of Science, Embase, Cochrane Library, Scopus, and clinical trials.gov databases were searched from January 2016 to May 2022. The following search terms were used: ctDNA OR circulating tumor DNA AND breast cancer OR breast carcinoma. Only studies written in English were included. The following pre-specified criteria should be met for inclusion: (i) original articles, conference abstracts, etc.; (ii) patients with breast cancer; (iii) ctDNA measurement; and (iv) clinical outcome data such as recurrence-free survival (RFS) and overall survival (OS). The random-effects model was preferred considering the potential heterogeneity across studies. The main outcomes are ctDNA detection rate and postoperative long-term outcomes (RFS and OS). Results: A total of 24 studies were screened. At every measurement time, the ctDNA detection rate of the HR+ subgroup was similar to that of the HR- subgroup (P = 0.075; P = 0.458; P = 0.744; and P = 0.578), and the ctDNA detection rate of the HER2+ subgroup was similar to that of the HER2- subgroup (P = 0.805; P = 0.271; P = 0.807; and P = 0.703). In the HR+ subgroup, RFS and OS of ctDNA positive patients were similar to those of ctDNA negative patients (P = 0.589 and P = 0.110), while RFS and OS of the ctDNA positive group was significantly shorter than those of the ctDNA negative patients in the HR- subgroup (HR = 4.03, P < 0.001; HR = 3.21, P < 0.001). According to HER grouping, the results were the same as above. In the triple negative breast cancer (TNBC) subgroup, the RFS and OS of ctDNA-positive patients was significantly shorter than of the ctDNA negative patients before and after surgery. Conclusions: ctDNA was more predictive of recurrence-free survival and overall survival in the HR- subgroup than in the HR+ subgroup, and the same result was showed in the HER2- subgroup vs. HER2+ subgroup. The prognosis of the TNBC subtype is closely related to ctDNA before and after surgery.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2667005424000267Test; https://doaj.org/toc/2667-0054Test

الوصول الحر: https://doaj.org/article/689c57a237054c7c801fe76b03245eefTest

المؤلفون: Chenyang Wu, Xiaowei Chen, Qiguang He

المصدر: Defence Technology, Vol 35, Iss , Pp 151-167 (2024)

مصطلحات موضوعية: Damage of rear plate, Debris cloud, Secondary impact, Hypervelocity yaw impact, FE-SPH adaptive method, Military Science

الوصف: The debris cloud generated by the hypervelocity impact (HVI) of orbiting space debris directly threatens the spacecraft. A full understanding of the damage mechanism of rear plate is useful for the optimal design of protective structures. In this study, the hypervelocity yaw impact of a cylindrical aluminum projectile on a double-layer aluminum plate is simulated by the FE-SPH adaptive method, and the damage process of the rear plate under the impact of the debris cloud is analyzed based on the debris cloud structure. The damage process can be divided into the main impact stage of the debris cloud and the structural response of the rear plate. The main impact stage lasts a short time and is the basis of the rear plate damage. In the stage of structure response, the continuous deformation and inertial motion of the rear plate dominate the perforation of the rear plate. We further analyze the damage mechanism and damage distribution characteristics of the rear plate in detail. Moreover, the connection between velocity space and position space of the debris cloud is established, which promotes the general analysis of the damage law of debris cloud. Based on the relationship, the features of typical damage areas are identified by the localized fine analysis. Both the cumulative effect and structural response cause the perforation of rear plate; in the non-perforated area, cratering by the impact of hazardous fragments is the main damage mode of the rear plate.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2214914724000151Test; https://doaj.org/toc/2214-9147Test

الوصول الحر: https://doaj.org/article/d4a63a9957e6423bb6e3c8013cb9efe3Test

المؤلفون: Yinghua Li, Yawen Lian, Xiaowei Chen, Hong Zhang, Guoxing Xu, Haoyang Duan, Xixi Xie, Zhenlan Li

المصدر: Journal of NeuroEngineering and Rehabilitation, Vol 21, Iss 1, Pp 1-11 (2024)

مصطلحات موضوعية: Stroke, Hand dysfunction, Force feedback hand rehabilitation robot, Task-oriented training, Neurorehabilitation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Abstract Background Over 80% of patients with stroke experience finger grasping dysfunction, affecting independence in activities of daily living and quality of life. In routine training, task-oriented training is usually used for functional hand training, which may improve finger grasping performance after stroke, while augmented therapy may lead to a better treatment outcome. As a new technology-supported training, the hand rehabilitation robot provides opportunities to improve the therapeutic effect by increasing the training intensity. However, most hand rehabilitation robots commonly applied in clinics are based on a passive training mode and lack the sensory feedback function of fingers, which is not conducive to patients completing more accurate grasping movements. A force feedback hand rehabilitation robot can compensate for these defects. However, its clinical efficacy in patients with stroke remains unknown. This study aimed to investigate the effectiveness and added value of a force feedback hand rehabilitation robot combined with task-oriented training in stroke patients with hemiplegia. Methods In this single-blinded randomised controlled trial, 44 stroke patients with hemiplegia were randomly divided into experimental (n = 22) and control (n = 22) groups. Both groups received 40 min/day of conventional upper limb rehabilitation training. The experimental group received 20 min/day of task-oriented training assisted by a force feedback rehabilitation robot, and the control group received 20 min/day of task-oriented training assisted by therapists. Training was provided for 4 weeks, 5 times/week. The Fugl-Meyer motor function assessment of the hand part (FMA-Hand), Action Research Arm Test (ARAT), grip strength, Modified Ashworth scale (MAS), range of motion (ROM), Brunnstrom recovery stages of the hand (BRS-H), and Barthel index (BI) were used to evaluate the effect of two groups before and after treatment. Results Intra-group comparison: In both groups, the FMA-Hand, ARAT, grip strength, AROM, BRS-H, and BI scores after 4 weeks of treatment were significantly higher than those before treatment (p 0.05). Inter-group comparison: After 4 weeks of treatment, the experimental group’s FMA-Hand total score, ARAT, grip strength, and AROM were significantly better than those of the control group (p 0.007). In addition, there were no statistically significant differences in MAS, BRS-H, and BI scores (p > 0.05). Conclusion Hand performance improved in patients with stroke after 4 weeks of task-oriented training. The use of a force feedback hand rehabilitation robot to support task-oriented training showed additional value over conventional task-oriented training in stroke patients with hand dysfunction. Clinical trial registration information NCT05841108

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1743-0003Test

الوصول الحر: https://doaj.org/article/be9c2da6ea7f406f8599a2b3490df5c7Test

المؤلفون: Guangyu Bai, Xiaowei Chen, Yue Peng, Ying Ji, Fenglong Bie, Yang Liu, Zhenlin Yang, Shugeng Gao

المصدر: Thoracic Cancer, Vol 15, Iss 14, Pp 1138-1148 (2024)

مصطلحات موضوعية: immunotherapy, neoadjuvant, postoperative complications, surgical challenge, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background In China, real‐world data on surgical challenges and postoperative complications after neoadjuvant immunotherapy of lung cancer are limited. Methods Patients were retrospectively enrolled from January 2018 to January 2023, and their clinical and pathological characters were subsequently analyzed. Surgical difficulty was categorized into a binary classification according to surgical duration: challenging or routine. Postoperative complications were graded using Clavien–Dindo grades. Logistic regression was used to identify risk factors affecting the duration of surgery and postoperative complications greater than Clavien–Dindo grade 2. Results In total, 261 patients were included. Of these, stage III patients accounted for 62.5% (163/261) at initial diagnosis, with 25.3% (66/261) at stage IIIB. Central‐type non‐small‐cell lung cancer accounted for 61.7% (161/261). One hundred and forty patients underwent video‐assisted thoracoscopic surgery and lobectomy accounted for 53.3% (139/261) of patients. Surgical time over average duration was defined as challenging surgeries, accounting for 43.7%. The postoperative complications rate of 261 patients was only 22.2%. Smoking history (odds ratio [OR] = 9.96, 95% [CI] 1.15–86.01, p = 0.03), chemoimmunotherapy (OR = 2.89, 95% CI 1.22–6.86, p = 0.02), and conversion to open surgery (OR = 11.3, 95% CI 1.38–92.9, p = 0.02) were identified as independent risk factors for challenging surgeries, while pneumonectomy (OR = 0.36, 95% CI 0.15–0.86, p= 0.02) was a protective factor. Meanwhile, pneumonectomy (OR = 7.51, 95% CI 2.40–23.51, p

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1759-7706Test; https://doaj.org/toc/1759-7714Test

الوصول الحر: https://doaj.org/article/4b477382a9f04d879d019ad11c8eb603Test

المؤلفون: Na'na Guo, Qingxin Zhou, Xiaowei Chen, Baoqi Zeng, Shanshan Wu, Hongmei Zeng, Feng Sun

المصدر: Journal of the National Cancer Center, Vol 4, Iss 1, Pp 63-73 (2024)

مصطلحات موضوعية: ctDNA, Breast cancer, Prognostic outcome prediction, Meta-analysis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Objective: Circulating tumor DNA (ctDNA) is increasingly being used as a potential prognosis biomarker in patients of breast cancer. This review aims to assess the clinical value of ctDNA in outcome prediction in breast cancer patients throughout the whole treatment cycle. Methods: PubMed, Web of Science, Embase, Cochrane Library, Scopus, and clinical trials.gov were searched from January 2016 to May 2022. Conference abstracts published in last three years were also included. The following search terms were used: ctDNA OR circulating tumor DNA AND breast cancer OR breast carcinoma. Only studies written in English languages were included. The following pre-specified criteria should be met for inclusion: (1) observational studies (prospective or retrospective), randomized control trials, case-control studies and case series studies; (2) patients with breast cancer; (3) ctDNA measurement; (4) clinical outcome data such as objective response rate (ORR), pathological complete response (pCR), relapse-free survival (RFS), overall survival (OS), and so on. The random-effect model was preferred considering the potential heterogeneity across studies. The primary outcomes included postoperative short-term outcomes (ORR and pCR) and postoperative long-term outcomes (RFS, OS, and relapse). Secondary outcomes focused on ctDNA detection rate. Results: A total of 30 studies, comprising of 19 cohort studies, 2 case-control studies and 9 case series studies were included. The baseline ctDNA was significantly negatively associated with ORR outcome (Relative Risk [RR] = 0.65, 95% confidence interval [CI]: 0.50–0.83), with lower ORR in the ctDNA-positive group than ctDNA-negative group. ctDNA during neoadjuvant therapy (NAT) treatment was significantly associated with pCR outcomes (Odds Ratio [OR] = 0.15, 95% CI: 0.04–0.54). The strong association between ctDNA and RFS or relapse outcome was significant across the whole treatment period, especially after the surgery (RFS: Hazard Ratio [HR] = 6.74, 95% CI: 3.73–12.17; relapse outcome: RR = 7.11, 95% CI: 3.05–16.53), although there was heterogeneity in these results. Pre-operative and post-operative ctDNA measurements were significantly associated with OS outcomes (pre-operative: HR = 2.03, 95% CI: 1.12–3.70; post-operative: HR = 6.03, 95% CI: 1.31–27.78). Conclusions: In this review, ctDNA measurements at different timepoints are correlated with evaluation indexes at different periods after treatment. The ctDNA can be used as an early potential postoperative prognosis biomarker in breast cancer, and also as a reference index to evaluate the therapeutic effect at different stages.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2667005424000036Test; https://doaj.org/toc/2667-0054Test

الوصول الحر: https://doaj.org/article/5a3f626127bb40d6b7e7601a7b0df3ffTest

المؤلفون: Mengyao Li, Wen Li, Shanshan Liang, Xiang Liao, Miaoqing Gu, Huiming Li, Xiaowei Chen, Hongliang Liu, Han Qin, Jingyu Xiao

المصدر: Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)

مصطلحات موضوعية: Biology (General), QH301-705.5

الوصف: Abstract The neural circuits underlying sleep-wakefulness and general anesthesia have not been fully investigated. The GABAergic neurons in the bed nucleus of the stria terminalis (BNST) play a critical role in stress and fear that relied on heightened arousal. Nevertheless, it remains unclear whether BNST GABAergic neurons are involved in the regulation of sleep-wakefulness and anesthesia. Here, using in vivo fiber photometry combined with electroencephalography, electromyography, and video recordings, we found that BNST GABAergic neurons exhibited arousal-state-dependent alterations, with high activities in both wakefulness and rapid-eye movement sleep, but suppressed during anesthesia. Optogenetic activation of these neurons could initiate and maintain wakefulness, and even induce arousal from anesthesia. However, chronic lesion of BNST GABAergic neurons altered spontaneous sleep-wakefulness architecture during the dark phase, but not induction and emergence from anesthesia. Furthermore, we also discovered that the BNST-ventral tegmental area pathway might participate in promoting wakefulness and reanimation from steady-state anesthesia. Collectively, our study explores new elements in neural circuit mechanisms underlying sleep-wakefulness and anesthesia, which may contribute to a more comprehensive understanding of consciousness and the development of innovative anesthetics.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2399-3642Test

الوصول الحر: https://doaj.org/article/dc3139de781f4e3dabf6f472de8cca0aTest

المؤلفون: Liangliang Wu, Limin Liu, Xin Zhao, Ming Zhou, Andie Fu, Yuping Zhang, Wenrui Yang, Xiaowei Chen, Wenjian Mo, Caixia Wang, Yumiao Li, Shilin Xu, Shiyi Pan, Ruiqing Zhou, Fankai Meng, Fengkui Zhang, Depei Wu, Shunqing Wang

المصدر: Blood Cancer Journal, Vol 14, Iss 1, Pp 1-5 (2024)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2044-5385Test

الوصول الحر: https://doaj.org/article/afca4577436a42a5958f889299c23d5cTest

المؤلفون: Yuan Li, Baihan Lyu, Rong Wang, Yue Peng, Haoyu Ran, Bolun Zhou, Yang Liu, Guangyu Bai, Qilin Huai, Xiaowei Chen, Chun Zeng, Qingchen Wu, Cheng Zhang, Shugeng Gao

المصدر: Thoracic Cancer, Vol 15, Iss 6, Pp 466-476 (2024)

مصطلحات موضوعية: lung adenocarcinoma, machine learning, pulmonary nodule, radiomics, tuberculosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background Radiomics is increasingly utilized to distinguish pulmonary nodules between lung adenocarcinoma (LUAD) and tuberculosis (TB). However, it remains unclear whether different segmentation criteria, such as the inclusion or exclusion of the cavity region within nodules, affect the results. Methods A total of 525 patients from two medical centers were retrospectively enrolled. The radiomics features were extracted according to two regions of interest (ROI) segmentation criteria. Multiple logistic regression models were trained to predict the pathology: (1) The clinical model relied on clinical‐radiological semantic features; (2) The radiomics models (radiomics+ and radiomics−) utilized radiomics features from different ROIs (including or excluding cavities); (3) the composite models (composite+ and composite−) incorporated both above. Results In the testing set, the radiomics+/− models and the composite+/− models still possessed efficient prediction performance (AUC ≥ 0.94), while the AUC of the clinical model was 0.881. In the validation set, the AUC of the clinical model was only 0.717, while that of the radiomics+/− models and the composite+/− models ranged from 0.801 to 0.825. The prediction performance of all the radiomics+/− and composite+/− models were significantly superior to that of the clinical model (p 0.05). Conclusions The present study established a machine learning‐based radiomics strategy for differentiating LUAD from TB lesions. The ROI segmentation including or excluding the cavity region may exert no significant effect on the predictive ability.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1759-7706Test; https://doaj.org/toc/1759-7714Test

الوصول الحر: https://doaj.org/article/0eaeefa7845b4a92ac340f45a56b564cTest