المؤلفون: Start, Alex O., Ryan, Gillian A., Cathcart, Barbra, Geraghty, Jennifer, Adams, Niamh, Colleran, Gabrielle, Vavasseur, Claudine, Caird, John, Murray, Dylan, Walsh, Jennifer M.

المساهمون: University College Dublin

المصدر: Irish Journal of Medical Science (1971 -) ; volume 192, issue 6, page 2881-2885 ; ISSN 0021-1265 1863-4362

مصطلحات موضوعية: General Medicine

الوصف: We present the case of a pregnant 32-year-old woman who presented with a giant fetal facial tumour at 22 weeks. The mass, initially 4 × 3.5 × 3 cm in size, was largely cystic with a small solid component. It subsequently increased to 9 × 9 × 10 cm. Significant compression effects on the fetal orbit, temple and infratemporal fossa, with potential compression of the optic nerve, were noted on ultrasound and MRI. The cyst required drainage twice in the pregnancy: firstly to reduce the compression effects and secondly to facilitate caesarean delivery. Postnatally, the baby had significant compression and displacement of the craniofacial skeleton from the mass effect. Postnatal histology revealed a diagnosis of a teratoma. This case highlights the complexities and challenges surrounding the diagnosis and management of a giant fetal facial tumour.

الإتاحة: https://doi.org/10.1007/s11845-023-03344-3Test

المؤلفون: Mui, Olivia O.T., Murray, Daniel B., Walsh, Bill, Crimmins, Darach W., Caird, John D.

المساهمون: Royal College of Surgeons in Ireland

المصدر: Child's Nervous System ; volume 39, issue 4, page 1051-1058 ; ISSN 0256-7040 1433-0350

مصطلحات موضوعية: Neurology (clinical), General Medicine, Pediatrics, Perinatology and Child Health

الوصف: Introduction The primary objective of neurosurgical management of malignant gliomas is maximal safe resection of the tumour. One of the main obstacles in achieving this is the ability to accurately discriminate between tumour edges and the surrounding healthy brain tissue. The use of fluorescence-guided surgery utilising 5-aminolevulinic acid (5-ALA), first introduced more than 20 years ago, has become an invaluable adjunct in high-grade glioma surgery in adults. However, as 5-ALA is not licensed for use in paediatric patients, the safety profile for such use remains undetermined. Case report We describe the case of a 4-year-old boy who underwent 5-ALA-guided resection of a fourth ventricle anaplastic ependymoma. Although complete resection was achieved and the patient awoke from surgery well with no neurological deficits, the patient developed acute transaminitis, anaemia, thrombocytopaenia and coagulopathy postoperatively. The patient had a sudden neurological deterioration on postoperative day 2; imaging revealed that he had suffered a spontaneous right frontal intracerebral haemorrhage. The patient returned to theatre for surgical decompression and evacuation of the haematoma, and ultimately went on to make a full recovery. Conclusion The use of 5-ALA in paediatric patients can be helpful in maximising surgical resection, but the associated safety profile remains undefined. Further research is urgently warranted in order to characterise the efficacy and risk of the use of 5-ALA in the paediatric population.

الإتاحة: https://doi.org/10.1007/s00381-023-05846-yTest

المؤلفون: Caird, John

الوصول الحر: https://www.europeana.eu/item/362/item_LTKU4PG4S665IUSPV2YPWTFLTTEFSNAC?utm_source=api&utm_medium=api&utm_campaign=YuvuWBeCaTest

المؤلفون: Kehoe, Laura^1,2,3 (AUTHOR) kehoela@tcd.ie, Caird, John^1,2 (AUTHOR), Crimmins, Darach^1,2,4 (AUTHOR)

المصدر: British Journal of Neurosurgery. Nov2023, p1-7. 7p. 2 Illustrations, 4 Charts.

مستخلص: Abstract Objectives Methods Results Conclusions To assess the effectiveness of subtemporal decompression in the management of slit ventricle syndrome.We conducted a retrospective review of all patients with slit ventricle syndrome (SVS) who underwent subtemporal decompression (STD) at our centre between 2010 and 2021. Cases were identified using the hospital database. Medical records for each patient were reviewed, including operative and radiological reports.Fifteen patients underwent STD for the management of SVS. Median age at time of STD was 9.18 years. Aetiology of hydrocephalus consisted of spinal dysraphism (5), idiopathic (4), post-infectious (1), post-haemorrhagic (3), secondary to tumour (1), and craniofacial anomalies (1). Median age at first shunt insertion was 3.4 months. Median pre-operative period assessed, from initial shunt insertion to STD, was 4.54 (interquartile range [IQR] 3.12–10.47) years. Twelve patients underwent ≥1 shunt revision prior to STD. All patients had a diagnosis of SVS at time of STD. Presenting symptoms, for the admission in which STD was performed, included nausea (9), vomiting (8), lethargy (8), headache (12), irritability (5), and visual disturbances (6). One third underwent shunt revision at the time of STD. Two patients developed post-operative complications requiring further surgery (meningitis requiring shunt revision: 1; wound debridement: 1). Three patients developed uncomplicated post-operative pyrexia, which was managed with antibiotics. Median duration of post-operative follow-up was 5.4 (IQR 1.73–8.54) years. Eleven patients underwent ≥1 shunt related procedure following STD. Wilcoxon signed-rank test demonstrated a significant difference in number of shunt related procedures before (median = 5, IQR 1–8) and after (median = 3, IQR 0–5) STD (Z = −2.083, p = .037). All patients reported subjective symptom improvement post-operatively. Thirteen patients experienced symptom recurrence at a median duration of 10 months post-operatively.STD was associated with a reduction in the amount of shunt related procedures required in this group of patients with SVS. Further study is required to confirm this association. [ABSTRACT FROM AUTHOR]

المؤلفون: O’Halloran, Philip J., Cleary, Anna, Cryan, Jane B., Beausang, Alan, Brett, Francesca M., Caird, John

المصدر: British Journal of Neurosurgery ; volume 36, issue 2, page 236-240 ; ISSN 0268-8697 1360-046X

الإتاحة: https://doi.org/10.1080/02688697.2021.1918327Test

المؤلفون: Start, Alex O., Ryan, Gillian, McParland, Peter, Crimmins, Darach, Caird, John, Mcauliffe, Fionnuala M.

المصدر: American Journal of Obstetrics and Gynecology ; volume 224, issue 2, page S275 ; ISSN 0002-9378

مصطلحات موضوعية: Obstetrics and Gynecology

الإتاحة: https://doi.org/10.1016/j.ajog.2020.12.452Test
https://api.elsevier.com/content/article/PII:S0002937820318287?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0002937820318287?httpAccept=text/plainTest

المؤلفون: Walsh, Aoiibhinn, Mernagh, Angela, Caird, John, Crimmins, Darach, Ringholz, Fiona, Williamson, Michael, Healy, Fiona

المصدر: Abstracts

الإتاحة: https://doi.org/10.1136/archdischild-2019-epa.339Test

المؤلفون: Tan, Joy, Caird, John, Nicholson, Alf

المصدر: Abstracts

الإتاحة: https://doi.org/10.1136/archdischild-2019-epa.190Test

المؤلفون: Trench, Luke, Bracken, Shirley, McInerney, Niall, Caird, John, Murray, Dylan J

المصدر: Abstracts

الإتاحة: https://doi.org/10.1136/archdischild-2019-epa.7Test

المؤلفون: O’Sullivan, Hugh, Bracken, Shirley, Caird, John, Kyne, Louise, Murray, Dylan, Doyle, Jodie

المصدر: Abstracts

الإتاحة: https://doi.org/10.1136/archdischild-2019-epa.76Test