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1دورية أكاديمية
المؤلفون: Kim, Hyun Young, Lee, Wonseok, Liu, Xiao, Jang, Haeum, Sakane, Sadatsugu, Weber, Raquel Carvalho-Gontijo, Diggle, Karin, Kerk, Samuel A, Metallo, Christian M, Kisseleva, Tatiana, Brenner, David A
المصدر: STAR Protocols. 5(2)
مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Chemical Sciences, Digestive Diseases, Substance Misuse, Liver Disease, Alcoholism, Alcohol Use and Health, Chronic Liver Disease and Cirrhosis, 5.2 Cellular and gene therapies, 2.1 Biological and endogenous factors, Development of treatments and therapeutic interventions, Aetiology, Stroke, Oral and gastrointestinal, Good Health and Well Being, cell isolation, metabolism, organoid
الوصف: Currently, there is no effective treatment for obesity and alcohol-associated liver diseases, partially due to the lack of translational human models. Here, we present a protocol to generate 3D human liver spheroids that contain all the liver cell types and mimic "livers in a dish." We describe strategies to induce metabolic and alcohol-associated hepatic steatosis, inflammation, and fibrosis. We outline potential applications, including using human liver spheroids for experimental and translational research and drug screening to identify potential anti-fibrotic therapies.
وصف الملف: application/pdf
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2كتاب
المؤلفون: Brenner, David A., Biller, Maxim, 1960-, בילר, מקסים, 1960-
المصدر: Longing, Belonging, and the Making of Jewish Consumer Culture. (2010) 201-226
مصطلحات موضوعية: Jewish literature -- History and criticism -- Germany, Jews -- History -- Germany -- 1945-
Subject Person: Biller, Maxim 1960
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3كتاب
المؤلفون: Brenner, David A.
المصدر: Visualizing the Holocaust. (2008) 261-276
مصطلحات موضوعية: Holocaust, Jewish (1939-1945), in motion pictures, Holocaust, Jewish (1939-1945) -- Humor
Subject Person: Mihaileanu, Radu. Train de vie (film)
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4كتاب
المؤلفون: Brenner, David A.
المصدر: Deutsch-jüdische Presse und jüdische Geschichte. I (2008) 303-318
مصطلحات موضوعية: Zionism -- Germany, Zionism -- Periodicals, Zionism in the press, Jewish wit and humor -- History and criticism, Schlemiel
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5دورية أكاديمية
المؤلفون: Osna, Natalia A, Tikhanovich, Irina, Ortega-Ribera, Martí, Mueller, Sebastian, Zheng, Chaowen, Mueller, Johannes, Li, Siyuan, Sakane, Sadatsugu, Weber, Raquel Carvalho Gontijo, Kim, Hyun Young, Lee, Wonseok, Ganguly, Souradipta, Kimura, Yusuke, Liu, Xiao, Dhar, Debanjan, Diggle, Karin, Brenner, David A, Kisseleva, Tatiana, Attal, Neha, McKillop, Iain H, Chokshi, Shilpa, Mahato, Ram, Rasineni, Karuna, Szabo, Gyongyi, Kharbanda, Kusum K
المصدر: Biomolecules. 14(4)
مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Digestive Diseases, Liver Disease, Hepatitis, Chronic Liver Disease and Cirrhosis, Alcoholism, Alcohol Use and Health, Substance Misuse, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Good Health and Well Being, alcohol-associated liver disease, epigenetics, cell death, hemolysis, MetAld, hepatic stellate cells, fibrosis, fatty acid binding protein 4, hepatocellular carcinoma, models, Liver, Animals, Humans, Liver Diseases, Alcoholic, Disease Progression, Epigenesis, Genetic, Hepatic Stellate Cells, Biochemistry and cell biology, Bioinformatics and computational biology, Medical biotechnology
الوصف: Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Multiple factors contribute to ALD progression and disease severity. Here, we overview several crucial mechanisms related to ALD end-stage outcome development, such as epigenetic changes, cell death, hemolysis, hepatic stellate cells activation, and hepatic fatty acid binding protein 4. Additionally, in this review, we also present two clinically relevant models using human precision-cut liver slices and hepatic organoids to examine ALD pathogenesis and progression.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/5b07d56sTest
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6دورية أكاديمية
المؤلفون: Kim, Hyun Young, Sakane, Sadatsugu, Eguileor, Alvaro, Weber, Raquel Carvalho Gontijo, Lee, Wonseok, Liu, Xiao, Lam, Kevin, Ishizuka, Kei, Rosenthal, Sara Brin, Diggle, Karin, Brenner, David A, Kisseleva, Tatiana
المصدر: Cellular and Molecular Gastroenterology and Hepatology. 17(1)
مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Liver Disease, Digestive Diseases, Chronic Liver Disease and Cirrhosis, 2.1 Biological and endogenous factors, Aetiology, Oral and gastrointestinal, Humans, Myofibroblasts, Liver Cirrhosis, Fibroblasts, Hepatocytes, Liver Fibrosis, Hepatic Stellate Cells, Portal Fibroblasts, Biochemistry and cell biology, Clinical sciences
الوصف: Liver fibrosis of different etiologies is a serious health problem worldwide. There is no effective therapy available for liver fibrosis except the removal of the underlying cause of injury or liver transplantation. Development of liver fibrosis is caused by fibrogenic myofibroblasts that are not present in the normal liver, but rather activate from liver resident mesenchymal cells in response to chronic toxic or cholestatic injury. Many studies indicate that liver fibrosis is reversible when the causative agent is removed. Regression of liver fibrosis is associated with the disappearance of activated myofibroblasts and resorption of the fibrous scar. In this review, we discuss the results of genetic tracing and cell fate mapping of hepatic stellate cells and portal fibroblasts, their specific characteristics, and potential phenotypes. We summarize research progress in the understanding of the molecular mechanisms underlying the development and reversibility of liver fibrosis, including activation, apoptosis, and inactivation of myofibroblasts.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/0vd8w0cxTest
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7كتاب
المؤلفون: Brenner, David A., Kafka, Franz, 1883-1924, Кафка, Франц, 1883-1924, קפקא, פרנץ, 1883-1924, كافكا، فرانتس،, 1883-1924
المصدر: Kafka, Zionism, and Beyond. (2004) 207-218
مصطلحات موضوعية: Human body in literature, Body image, Jews -- Identity, Homosexuality in literature, Jewish gay people
Subject Person: Kafka, Franz 1883-1924
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8كتاب
المؤلفون: Brenner, David A.
المصدر: Evolving Jewish Identities in German Culture. (2000) 45-61
مصطلحات موضوعية: Jews -- Germany, Judaism -- Relations -- Christianity, Christianity and other religions -- Judaism, Jews -- History -- Germany -- 1800-2000, Jews -- Germany -- Periodicals, Jewish literature -- History and criticism -- Germany, Israelitisches Familienblatt
الوصف: On two serial novels on German-Jewish reconciliation which appeared in the "Israelitisches Familienblatt": Meta Opet-Fuss' "Versöhnung" and Martin Salomonski's "Die geborene Tugendreich" (1922-23).
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9كتاب
المصدر: Germanic Review. 75,4 (2000) 296-311
مصطلحات موضوعية: Holocaust, Jewish (1939-1945), in motion pictures, Holocaust, Jewish (1939-1945) -- Influence, Holocaust, Jewish (1939-1945) -- Terminology
Subject Person: Spielberg, Steven 1946 Schindler's List (film), Goldhagen, Daniel Jonah. Hitler's Willing Executioners; Ordinary Germans and the Holocaust (review)
الوصف: In terms of representation of the Holocaust, locates both Spielberg's film and Goldhagen's book in the literalist camp - i.e. stressing particular events of unbearable horror. Considers receptions of the film and of the book by audiences in the USA and Germany.
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10كتاب
المؤلفون: Brenner, David A.
المصدر: Leo Baeck Institute Year Book. 42 (1997) 49-66
مصطلحات موضوعية: Jews -- Germany -- Periodicals, Theater, Yiddish, Ost und West
النص الكامل