المؤلفون: He, Karen Y, Li, Xiaoyin, Kelly, Tanika N, Liang, Jingjing, Cade, Brian E, Assimes, Themistocles L, Becker, Lewis C, Beitelshees, Amber L, Bress, Adam P, Chang, Yen-Pei Christy, Chen, Yii-Der Ida, de Vries, Paul S, Fox, Ervin R, Franceschini, Nora, Furniss, Anna, Gao, Yan, Guo, Xiuqing, Haessler, Jeffrey, Hwang, Shih-Jen, Irvin, Marguerite Ryan, Kalyani, Rita R, Liu, Ching-Ti, Liu, Chunyu, Martin, Lisa Warsinger, Montasser, May E, Muntner, Paul M, Mwasongwe, Stanford, Palmas, Walter, Reiner, Alex P, Shimbo, Daichi, Smith, Jennifer A, Snively, Beverly M, Yanek, Lisa R, Boerwinkle, Eric, Correa, Adolfo, Cupples, L Adrienne, He, Jiang, Kardia, Sharon LR, Kooperberg, Charles, Mathias, Rasika A, Mitchell, Braxton D, Psaty, Bruce M, Vasan, Ramachandran S, Rao, DC, Rich, Stephen S, Rotter, Jerome I, Wilson, James G, Chakravarti, Aravinda, Morrison, Alanna C, Levy, Daniel, Arnett, Donna K, Redline, Susan, Zhu, Xiaofeng

المصدر: Human Genetics. 138(2)

مصطلحات موضوعية: Biological Sciences, Genetics, Biotechnology, Heart Disease, Human Genome, Cardiovascular, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Alternative Splicing, Blood Pressure, Chromosomes, Human, Pair 16, Exome, Female, Follow-Up Studies, Genetic Linkage, Genetic Variation, Genome, Human, Genome-Wide Association Study, High-Throughput Nucleotide Sequencing, Humans, Male, RNA Splicing Factors, Recombinases, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Blood Pressure Working Group, Complementary and Alternative Medicine, Paediatrics and Reproductive Medicine, Genetics & Heredity, Reproductive medicine

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2g02g3gsTest

المؤلفون: Kilpeläinen, Tuomas O, Bentley, Amy R, Noordam, Raymond, Sung, Yun Ju, Schwander, Karen, Winkler, Thomas W, Jakupović, Hermina, Chasman, Daniel I, Manning, Alisa, Ntalla, Ioanna, Aschard, Hugues, Brown, Michael R, de Las Fuentes, Lisa, Franceschini, Nora, Guo, Xiuqing, Vojinovic, Dina, Aslibekyan, Stella, Feitosa, Mary F, Kho, Minjung, Musani, Solomon K, Richard, Melissa, Wang, Heming, Wang, Zhe, Bartz, Traci M, Bielak, Lawrence F, Campbell, Archie, Dorajoo, Rajkumar, Fisher, Virginia, Hartwig, Fernando P, Horimoto, Andrea RVR, Li, Changwei, Lohman, Kurt K, Marten, Jonathan, Sim, Xueling, Smith, Albert V, Tajuddin, Salman M, Alver, Maris, Amini, Marzyeh, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Evangelou, Evangelos, Gao, Chuan, Graff, Mariaelisa, Harris, Sarah E, He, Meian, Hsu, Fang-Chi, Jackson, Anne U, Zhao, Jing Hua, Kraja, Aldi T, Kühnel, Brigitte, Laguzzi, Federica, Lyytikäinen, Leo-Pekka, Nolte, Ilja M, Rauramaa, Rainer, Riaz, Muhammad, Robino, Antonietta, Rueedi, Rico, Stringham, Heather M, Takeuchi, Fumihiko, van der Most, Peter J, Varga, Tibor V, Verweij, Niek, Ware, Erin B, Wen, Wanqing, Li, Xiaoyin, Yanek, Lisa R, Amin, Najaf, Arnett, Donna K, Boerwinkle, Eric, Brumat, Marco, Cade, Brian, Canouil, Mickaël, Chen, Yii-Der Ida, Concas, Maria Pina, Connell, John, de Mutsert, Renée, de Silva, H Janaka, de Vries, Paul S, Demirkan, Ayşe, Ding, Jingzhong, Eaton, Charles B, Faul, Jessica D, Friedlander, Yechiel, Gabriel, Kelley P, Ghanbari, Mohsen, Giulianini, Franco, Gu, Chi Charles, Gu, Dongfeng, Harris, Tamara B, He, Jiang, Heikkinen, Sami, Heng, Chew-Kiat, Hunt, Steven C, Ikram, M Arfan, Jonas, Jost B, Koh, Woon-Puay, Komulainen, Pirjo, Krieger, Jose E

المصدر: Nature communications. 10(1)

مصطلحات موضوعية: Lifelines Cohort Study, Humans, Cholesterol, Lipids, Triglycerides, Calcium-Binding Proteins, Muscle Proteins, Microtubule-Associated Proteins, Membrane Proteins, Nerve Tissue Proteins, Transcription Factors, Exercise, Genotype, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, African Continental Ancestry Group, Asian Continental Ancestry Group, European Continental Ancestry Group, Hispanic Americans, Brazil, Female, Male, Lipid Metabolism, Cholesterol, LDL, Cholesterol, HDL, Genome-Wide Association Study, Young Adult, Genetic Loci, LIM-Homeodomain Proteins, and over, HDL, LDL

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/83v1c0f8Test

المؤلفون: Liu, Jun, Carnero-Montoro, Elena, van Dongen, Jenny, Lent, Samantha, Nedeljkovic, Ivana, Ligthart, Symen, Tsai, Pei-Chien, Martin, Tiphaine C, Mandaviya, Pooja R, Jansen, Rick, Peters, Marjolein J, Duijts, Liesbeth, Jaddoe, Vincent WV, Tiemeier, Henning, Felix, Janine F, Willemsen, Gonneke, de Geus, Eco JC, Chu, Audrey Y, Levy, Daniel, Hwang, Shih-Jen, Bressler, Jan, Gondalia, Rahul, Salfati, Elias L, Herder, Christian, Hidalgo, Bertha A, Tanaka, Toshiko, Moore, Ann Zenobia, Lemaitre, Rozenn N, Jhun, Min A, Smith, Jennifer A, Sotoodehnia, Nona, Bandinelli, Stefania, Ferrucci, Luigi, Arnett, Donna K, Grallert, Harald, Assimes, Themistocles L, Hou, Lifang, Baccarelli, Andrea, Whitsel, Eric A, van Dijk, Ko Willems, Amin, Najaf, Uitterlinden, André G, Sijbrands, Eric JG, Franco, Oscar H, Dehghan, Abbas, Spector, Tim D, Dupuis, Josée, Hivert, Marie-France, Rotter, Jerome I, Meigs, James B, Pankow, James S, van Meurs, Joyce BJ, Isaacs, Aaron, Boomsma, Dorret I, Bell, Jordana T, Demirkan, Ayşe, van Duijn, Cornelia M

المصدر: Nature Communications. 10(1)

مصطلحات موضوعية: Biological Sciences, Genetics, Nutrition, Diabetes, Human Genome, Obesity, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Adult, Aged, Aged, 80 and over, Computer Simulation, CpG Islands, DNA Methylation, Diabetes Mellitus, Type 2, Epigenesis, Genetic, Epigenomics, Female, Gene Expression Profiling, Gene Expression Regulation, Genome-Wide Association Study, Glucose, Homeostasis, Humans, Insulin, Male, Metabolic Networks and Pathways, Middle Aged, Polymorphism, Single Nucleotide, Young Adult

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/36s061tsTest

المؤلفون: Hidalgo, Bertha A, Sofer, Tamar, Qi, Qibin, Schneiderman, Neil, Chen, Y-D Ida, Kaplan, Robert C, Avilés-Santa, M Larissa, North, Kari E, Arnett, Donna K, Szpiro, Adam, Cai, Jianwen, Yu, Bing, Boerwinkle, Eric, Papanicolaou, George, Laurie, Cathy C, Rotter, Jerome I, Stilp, Adrienne M

المصدر: Scientific Reports. 9(1)

مصطلحات موضوعية: Biological Sciences, Genetics, Diabetes, Prevention, Nutrition, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Diabetes Mellitus, Type 2, Genetic Association Studies, Genetic Predisposition to Disease, Haplotypes, Hispanic or Latino, Humans, Monocarboxylic Acid Transporters, Polymorphism, Single Nucleotide, United States

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/42t3c4hcTest

المؤلفون: Nkomo, Vuyisile T., Arnett, Donna K., Benjamin, Emelia J., Liebson, Philip R., Hutchinson, Richard G., Skelton, Thomas N.

المصدر: Nkomo, Vuyisile T. and Arnett, Donna K. and Benjamin, Emelia J. and Liebson, Philip R. and Hutchinson, Richard G. and Skelton, Thomas N. (2004) Left Ventricular Structure and Systolic Function in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study. Ethnicity & Disease, 14 (4). pp. 483-488. ISSN 1049-510X

العلاقة: http://www.ishib.org/ED_journal_14_4.aspTest; http://health-equity.pitt.edu/1178Test/

المؤلفون: Young, Kristin L., Fisher, Virginia, Deng, Xuan, Brody, Jennifer A., Graff, Misa, Lim, Elise, Lin, Bridget M., Xu, Hanfei, Amin, Najaf, An, Ping, Aslibekyan, Stella, Fohner, Alison E., Hidalgo, Bertha, Lenzini, Petra, Kraaij, Robert, Medina-Gomez, Carolina, Prokić, Ivana, Rivadeneira, Fernando, Sitlani, Colleen, Tao, Ran, van Rooij, Jeroen, Zhang, Di, Broome, Jai G., Buth, Erin J., Heavner, Benjamin D., Jain, Deepti, Smith, Albert V., Barnes, Kathleen, Boorgula, Meher Preethi, Chavan, Sameer, Darbar, Dawood, De Andrade, Mariza, Guo, Xiuqing, Haessler, Jeffrey, Irvin, Marguerite R., Kalyani, Rita R., Kardia, Sharon L.R., Kooperberg, Charles, Kim, Wonji, Mathias, Rasika A., McDonald, Merry Lynn, Mitchell, Braxton D., Peyser, Patricia A., Regan, Elizabeth A., Redline, Susan, Reiner, Alexander P., Rich, Stephen S., Rotter, Jerome I., Smith, Jennifer A., Weiss, Scott, Wiggins, Kerri L., Yanek, Lisa R., Arnett, Donna, Heard-Costa, Nancy L., Leal, Suzanne, Lin, Danyu, McKnight, Barbara, Province, Michael, van Duijn, Cornelia M., North, Kari E., Cupples, L. Adrienne, Liu, Ching Ti

المصدر: Young , K L , Fisher , V , Deng , X , Brody , J A , Graff , M , Lim , E , Lin , B M , Xu , H , Amin , N , An , P , Aslibekyan , S , Fohner , A E , Hidalgo , B , Lenzini , P , Kraaij , R , Medina-Gomez , C , Prokić , I , Rivadeneira , F , Sitlani , C , Tao , R , van Rooij , J , Zhang , D , Broome , J G , Buth ....

وصف الملف: application/pdf

العلاقة: https://pure.eur.nl/en/publications/cab4dc35-d96b-49c1-93ce-f53105463a48Test

الإتاحة: https://doi.org/10.1016/j.xhgg.2022.100163Test
https://pure.eur.nl/en/publications/cab4dc35-d96b-49c1-93ce-f53105463a48Test
https://pure.eur.nl/ws/files/77621942/Whole_exome_sequence_analysis_of_anthropometric_traits_illustrates_challenges_in_identifying_effects_of_rare_genetic_variants.pdfTest
http://www.scopus.com/inward/record.url?scp=85144046616&partnerID=8YFLogxKTest

المؤلفون: Saunders, Gretchen R. B., Wang, Xingyan, Chen, Fang, Jang, Seon-Kyeong, Liu, Mengzhen, Wang, Chen, Gao, Shuang, Jiang, Yu, Khunsriraksakul, Chachrit, Otto, Jacqueline M., Addison, Clifton, Akiyama, Masato, Albert, Christine M., Aliev, Fazil, Alonso, Alvaro, Arnett, Donna K., Ashley-Koch, Allison E., Ashrani, Aneel A., Barnes, Kathleen C., Barr, R. Graham, Bartz, Traci M., Becker, Diane M., Bielak, Lawrence F., Benjamin, Emelia J., Bis, Joshua C., Bjornsdottir, Gyda, Blangero, John, Bleecker, Eugene R., Boardman, Jason D., Boerwinkle, Eric, Boomsma, Dorret, Boorgula, Meher Preethi, Bowden, Donald W., Brody, Jennifer A., Cade, Brian E., Chasman, Daniel, Chavan, Sameer, Chen, Yii-Der Ida, Chen, Zhengming, Cheng, Iona, Cho, Michael H., Choquet, Helene, Cole, John W., Cornelis, Marilyn C., Cucca, Francesco, Curran, Joanne E., de Andrade, Mariza, Dick, Danielle M., Docherty, Anna R., Duggirala, Ravindranath, Eaton, Charles B., Ehringer, Marissa A., Esko, Tonu, Faul, Jessica D., Silva, Lilian Fernandes, Fiorillo, Edoardo, Fornage, Myriam, Freedman, Barry, Gabrielsen, Maiken E., Garrett, Melanie E., Gharib, Sina A., Gieger, Christian, Gillespie, Nathan, Glahn, David C., Gordon, Scott D., Gu, Charles C., Gu, Dongfeng, Gudbjartsson, Daniel F., Guo, Xiuqing, Haessler, Jeffrey, Hall, Michael E., Haller, Toomas, Harris, Kathleen Mullan, He, Jiang, Herd, Pamela, Hewitt, John K., Hickie, Ian, Hidalgo, Bertha, Hokanson, John E., Hopfer, Christian, Hottenga, JoukeJan, Hou, Lifang, Huang, Hongyan, Hung, Yi-Jen, Hunter, David J., Hveem, Kristian, Hwang, Shih-Jen, Hwu, Chii-Min, Iacono, William, Irvin, Marguerite R., Jee, Yon Ho, Johnson, Eric O., Joo, Yoonjung Y., Jorgenson, Eric, Justice, Anne E., Kamatani, Yoichiro, Kaplan, Robert C., Kaprio, Jaakko, Kardia, Sharon L. R., Keller, Matthew C., Kelly, Tanika N., Kooperberg, Charles, Korhonen, Tellervo, Kraft, Peter, Krauter, Kenneth, Kuusisto, Johanna, Laakso, Markku, Lasky-Su, Jessica, Lee, Wen-Jane, Lee, James J., Levy, Daniel, Li, Liming, Li, Kevin, Li, Yuqing, Lin, Kuang, Lind, Penelope A., Liu, Chunyu, Lloyd-Jones, Donald M., Lutz, Sharon M., Ma, Jiantao, Magi, Reedik, Manichaikul, Ani, Martin, Nicholas G., Mathur, Ravi, Matoba, Nana, McArdle, Patrick F., McGue, Matt, McQueen, Matthew B., Medland, Sarah E., Metspalu, Andres, Meyers, Deborah A., Millwood, Iona Y., Mitchell, Braxton D., Mohlke, Karen L., Moll, Matthew, Montasser, May E., Morrison, Alanna C., Mulas, Antonella, Nielsen, Jonas B., North, Kari E., Oelsner, Elizabeth C., Okada, Yukinori, Orru, Valeria, Palmer, Nicholette D., Palviainen, Teemu, Pandit, Anita, Park, S. Lani, Peters, Ulrike, Peters, Annette, Peyser, Patricia A., Polderman, Tinca J. C., Rafaels, Nicholas, Redline, Susan, Reed, Robert M., Reiner, Alex P., Rice, John P., Rich, Stephen S., Richmond, Nicole E., Roan, Carol, Rotter, Jerome, Rueschman, Michael N., Runarsdottir, Valgerdur, Saccone, Nancy L., Schwartz, David A., Shadyab, Aladdin H., Shi, Jingchunzi, Shringarpure, Suyash S., Sicinski, Kamil, Skogholt, Anne Heidi, Smith, Jennifer A., Smith, Nicholas L., Sotoodehnia, Nona, Stallings, Michael C., Stefansson, Hreinn, Stefansson, Kari, Stitzel, Jerry A., Sun, Xiao, Syed, Moin, Tal-Singer, Ruth, Taylor, Amy E., Taylor, Kent D., Telen, Marilyn J., Thai, Khanh K., Tiwari, Hemant, Turman, Constance, Tyrfingsson, Thorarinn, Wall, Tamara L., Walters, Robin G., Weir, David R., Weiss, Scott T., White, Wendy B., Whitfield, John B., Wiggins, Kerri L., Willemsen, Gonneke, Willer, Cristen J., Winsvold, Bendik S., Xu, Huichun, Yanek, Lisa R., Yin, Jie, Young, Kristin L., Young, Kendra A., Yu, Bing, Zhao, Wei, Zhou, Wei, Zollner, Sebastian, Zuccolo, Luisa, Project, The Biobank Japan, Batini, Chiara, Bergen, Andrew W., Bierut, Laura J., David, Sean P., Taliun, Sarah A. Gagliano, Hancock, Dana B., Jiang, Bibo, Munafo, Marcus R., Thorgeirsson, Thorgeir E., Liu, Dajiang J., Vrieze, Scott

المساهمون: Institute for Molecular Medicine Finland, University Management, Tellervo Korhonen / Principal Investigator, Genetic Epidemiology, University of Helsinki

مصطلحات موضوعية: Neurotrophic factors, Disease, Prediction, Protein, Model, 3111 Biomedicine, 1184 Genetics, developmental biology, physiology

وصف الملف: application/pdf

العلاقة: Saunders , G R B , Wang , X , Chen , F , Jang , S-K , Liu , M , Wang , C , Gao , S , Jiang , Y , Khunsriraksakul , C , Otto , J M , Addison , C , Akiyama , M , Albert , C M , Aliev , F , Alonso , A , Arnett , D K , Ashley-Koch , A E , Ashrani , A A , Barnes , K C , Barr , R G , Bartz , T M , Becker , D M , Bielak , L F , Benjamin , E J , Bis , J C , Bjornsdottir , G , Blangero , J , Bleecker , E R , Boardman , J D , Boerwinkle , E , Boomsma , D , Boorgula , M P , Bowden , D W , Brody , J A , Cade , B E , Chasman , D , Chavan , S , Chen , Y-D I , Chen , Z , Cheng , I , Cho , M H , Choquet , H , Cole , J W , Cornelis , M C , Cucca , F , Curran , J E , de Andrade , M , Dick , D M , Docherty , A R , Duggirala , R , Eaton , C B , Ehringer , M A , Esko , T , Faul , J D , Silva , L F , Fiorillo , E , Fornage , M , Freedman , B , Gabrielsen , M E , Garrett , M E , Gharib , S A , Gieger , C , Gillespie , N , Glahn , D C , Gordon , S D , Gu , C C , Gu , D , Gudbjartsson , D F , Guo , X , Haessler , J , Hall , M E , Haller , T , Harris , K M , He , J , Herd , P , Hewitt , J K , Hickie , I , Hidalgo , B , Hokanson , J E , Hopfer , C , Hottenga , J , Hou , L , Huang , H , Hung , Y-J , Hunter , D J , Hveem , K , Hwang , S-J , Hwu , C-M , Iacono , W , Irvin , M R , Jee , Y H , Johnson , E O , Joo , Y Y , Jorgenson , E , Justice , A E , Kamatani , Y , Kaplan , R C , Kaprio , J , Kardia , S L R , Keller , M C , Kelly , T N , Kooperberg , C , Korhonen , T , Kraft , P , Krauter , K , Kuusisto , J , Laakso , M , Lasky-Su , J , Lee , W-J , Lee , J J , Levy , D , Li , L , Li , K , Li , Y , Lin , K , Lind , P A , Liu , C , Lloyd-Jones , D M , Lutz , S M , Ma , J , Magi , R , Manichaikul , A , Martin , N G , Mathur , R , Matoba , N , McArdle , P F , McGue , M , McQueen , M B , Medland , S E , Metspalu , A , Meyers , D A , Millwood , I Y , Mitchell , B D , Mohlke , K L , Moll , M , Montasser , M E , Morrison , A C , Mulas , A , Nielsen , J B , North , K E , Oelsner , E C , Okada , Y , Orru , V , Palmer , N D , Palviainen , T , Pandit , A , Park , S L , Peters , U , Peters , A , Peyser , P A , Polderman , T J C , Rafaels , N , Redline , S , Reed , R M , Reiner , A P , Rice , J P , Rich , S S , Richmond , N E , Roan , C , Rotter , J , Rueschman , M N , Runarsdottir , V , Saccone , N L , Schwartz , D A , Shadyab , A H , Shi , J , Shringarpure , S S , Sicinski , K , Skogholt , A H , Smith , J A , Smith , N L , Sotoodehnia , N , Stallings , M C , Stefansson , H , Stefansson , K , Stitzel , J A , Sun , X , Syed , M , Tal-Singer , R , Taylor , A E , Taylor , K D , Telen , M J , Thai , K K , Tiwari , H , Turman , C , Tyrfingsson , T , Wall , T L , Walters , R G , Weir , D R , Weiss , S T , White , W B , Whitfield , J B , Wiggins , K L , Willemsen , G , Willer , C J , Winsvold , B S , Xu , H , Yanek , L R , Yin , J , Young , K L , Young , K A , Yu , B , Zhao , W , Zhou , W , Zollner , S , Zuccolo , L , Project , T B J , Batini , C , Bergen , A W , Bierut , L J , David , S P , Taliun , S A G , Hancock , D B , Jiang , B , Munafo , M R , Thorgeirsson , T E , Liu , D J & Vrieze , S 2022 , ' Genetic diversity fuels gene discovery for tobacco and alcohol use ' , Nature , vol. 612 , no. 7941 , pp. 720-+ . https://doi.org/10.1038/s41586-022-05477-4Test; ORCID: /0000-0002-7847-8384/work/131544632; ORCID: /0000-0003-2838-3085/work/155650939; http://hdl.handle.net/10138/356325Test; e9423bdf-9d68-44c3-9d16-9ab7d57a7fa3; 000934065100025

الإتاحة: http://hdl.handle.net/10138/356325Test

المؤلفون: Kanoni, Stavroula, Graham, Sarah E., Wang, Yuxuan, Surakka, Ida, Ramdas, Shweta, Zhu, Xiang, Clarke, Shoa L., Bhatti, Konain Fatima, Vedantam, Sailaja, Winkler, Thomas W., Locke, Adam E., Marouli, Eirini, Zajac, Greg J.M., Wu, Kuan Han H., Ntalla, Ioanna, Hui, Qin, Klarin, Derek, Hilliard, Austin T., Wang, Zeyuan, Xue, Chao, Thorleifsson, Gudmar, Helgadottir, Anna, Gudbjartsson, Daniel F., Holm, Hilma, Olafsson, Isleifur, Hwang, Mi Yeong, Han, Sohee, Akiyama, Masato, Sakaue, Saori, Terao, Chikashi, Kanai, Masahiro, Zhou, Wei, Brumpton, Ben M., Rasheed, Humaira, Havulinna, Aki S., Veturi, Yogasudha, Pacheco, Jennifer Allen, Rosenthal, Elisabeth A., Lingren, Todd, Feng, Qi Ping, Kullo, Iftikhar J., Narita, Akira, Takayama, Jun, Martin, Hilary C., Hunt, Karen A., Trivedi, Bhavi, Haessler, Jeffrey, Giulianini, Franco, Bradford, Yuki, Miller, Jason E., Campbell, Archie, Lin, Kuang, Millwood, Iona Y., Rasheed, Asif, Hindy, George, Faul, Jessica D., Zhao, Wei, Weir, David R., Turman, Constance, Huang, Hongyan, Graff, Mariaelisa, Choudhury, Ananyo, Sengupta, Dhriti, Mahajan, Anubha, Brown, Michael R., Zhang, Weihua, Yu, Ketian, Schmidt, Ellen M., Pandit, Anita, Gustafsson, Stefan, Yin, Xianyong, Luan, Jian’an, Zhao, Jing Hua, Matsuda, Fumihiko, Jang, Hye Mi, Yoon, Kyungheon, Medina-Gomez, Carolina, Pitsillides, Achilleas, Hottenga, Jouke Jan, Wood, Andrew R., Ji, Yingji, Gao, Zishan, Haworth, Simon, Yousri, Noha A., Mitchell, Ruth E., Chai, Jin Fang, Aadahl, Mette, Bjerregaard, Anne A., Yao, Jie, Manichaikul, Ani, Hwu, Chii Min, Hung, Yi Jen, Warren, Helen R., Ramirez, Julia, Bork-Jensen, Jette, Kårhus, Line L., Goel, Anuj, Sabater-Lleal, Maria, Noordam, Raymond, Mauro, Pala, Matteo, Floris, McDaid, Aaron F., Marques-Vidal, Pedro, Wielscher, Matthias, Trompet, Stella, Sattar, Naveed, Møllehave, Line T., Munz, Matthias, Zeng, Lingyao, Huang, Jianfeng, Yang, Bin, Poveda, Alaitz, Kurbasic, Azra, Lamina, Claudia, Forer, Lukas, Scholz, Markus, Galesloot, Tessel E., Bradfield, Jonathan P., Ruotsalainen, Sanni E., Daw, EWarwick W., Zmuda, Joseph M., Mitchell, Jonathan S., Fuchsberger, Christian, Christensen, Henry, Brody, Jennifer A., Vazquez-Moreno, Miguel, Feitosa, Mary F., Wojczynski, Mary K., Wang, Zhe, Preuss, Michael H., Mangino, Massimo, Christofidou, Paraskevi, Verweij, Niek, Benjamins, Jan W., Engmann, Jorgen, Tsao, Noah L., Verma, Anurag, Slieker, Roderick C., Lo, Ken Sin, Zilhao, Nuno R., Le, Phuong, Kleber, Marcus E., Delgado, Graciela E., Huo, Shaofeng, Ikeda, Daisuke D., Iha, Hiroyuki, Yang, Jian, Liu, Jun, Demirkan, Ayşe, Leonard, Hampton L., Marten, Jonathan, Frank, Mirjam, Schmidt, Börge, Smyth, Laura J., Cañadas-Garre, Marisa, Wang, Chaolong, Nakatochi, Masahiro, Wong, Andrew, Hutri-Kähönen, Nina, Sim, Xueling, Xia, Rui, Huerta-Chagoya, Alicia, Fernandez-Lopez, Juan Carlos, Lyssenko, Valeriya, Nongmaithem, Suraj S., Bayyana, Swati, Stringham, Heather M., Irvin, Marguerite R., Oldmeadow, Christopher, Kim, Han Na, Ryu, Seungho, Timmers, Paul R.H.J., Arbeeva, Liubov, Dorajoo, Rajkumar, Lange, Leslie A., Prasad, Gauri, Lorés-Motta, Laura, Pauper, Marc, Long, Jirong, Li, Xiaohui, Theusch, Elizabeth, Takeuchi, Fumihiko, Spracklen, Cassandra N., Loukola, Anu, Bollepalli, Sailalitha, Warner, Sophie C., Wang, Ya Xing, Wei, Wen B., Nutile, Teresa, Ruggiero, Daniela, Sung, Yun Ju, Chen, Shufeng, Liu, Fangchao, Yang, Jingyun, Kentistou, Katherine A., Banas, Bernhard, Nardone, Giuseppe Giovanni, Meidtner, Karina, Bielak, Lawrence F., Smith, Jennifer A., Hebbar, Prashantha, Farmaki, Aliki Eleni, Hofer, Edith, Lin, Maoxuan, Concas, Maria Pina, Vaccargiu, Simona, van der Most, Peter J., Pitkänen, Niina, Cade, Brian E., van der Laan, Sander W., Chitrala, Kumaraswamy Naidu, Weiss, Stefan, Bentley, Amy R., Doumatey, Ayo P., Adeyemo, Adebowale A., Lee, Jong Young, Petersen, Eva R.B., Nielsen, Aneta A., Choi, Hyeok Sun, Nethander, Maria, Freitag-Wolf, Sandra, Southam, Lorraine, Rayner, Nigel W., Wang, Carol A., Lin, Shih Yi, Wang, Jun Sing, Couture, Christian, Lyytikäinen, Leo Pekka, Nikus, Kjell, Cuellar-Partida, Gabriel, Vestergaard, Henrik, Hidalgo, Bertha, Giannakopoulou, Olga, Cai, Qiuyin, Obura, Morgan O., van Setten, Jessica, Li, Xiaoyin, Liang, Jingjing, Tang, Hua, Terzikhan, Natalie, Shin, Jae Hun, Jackson, Rebecca D., Reiner, Alexander P., Martin, Lisa Warsinger, Chen, Zhengming, Li, Liming, Kawaguchi, Takahisa, Thiery, Joachim, Bis, Joshua C., Launer, Lenore J., Li, Huaixing, Nalls, Mike A., Raitakari, Olli T., Ichihara, Sahoko, Wild, Sarah H., Nelson, Christopher P., Campbell, Harry, Jäger, Susanne, Nabika, Toru, Al-Mulla, Fahd, Niinikoski, Harri, Braund, Peter S., Kolcic, Ivana, Kovacs, Peter, Giardoglou, Tota, Katsuya, Tomohiro, de Kleijn, Dominique, de Borst, Gert J., Kim, Eung Kweon, Adams, Hieab H.H., Ikram, M. Arfan, Zhu, Xiaofeng, Asselbergs, Folkert W., Kraaijeveld, Adriaan O., Beulens, Joline W.J., Shu, Xiao Ou, Rallidis, Loukianos S., Pedersen, Oluf, Hansen, Torben, Mitchell, Paul, Hewitt, Alex W., Kähönen, Mika, Pérusse, Louis, Bouchard, Claude, Tönjes, Anke, Chen, Yii Der Ida, Pennell, Craig E., Mori, Trevor A., Lieb, Wolfgang, Franke, Andre, Ohlsson, Claes, Mellström, Dan, Cho, Yoon Shin, Lee, Hyejin, Yuan, Jian Min, Koh, Woon Puay, Rhee, Sang Youl, Woo, Jeong Taek, Heid, Iris M., Stark, Klaus J., Zimmermann, Martina E., Völzke, Henry, Homuth, Georg, Evans, Michele K., Zonderman, Alan B., Polasek, Ozren, Pasterkamp, Gerard, Hoefer, Imo E., Redline, Susan, Pahkala, Katja, Oldehinkel, Albertine J., Snieder, Harold, Biino, Ginevra, Schmidt, Reinhold, Schmidt, Helena, Bandinelli, Stefania, Dedoussis, George, Thanaraj, Thangavel Alphonse, Kardia, Sharon L.R., Peyser, Patricia A., Kato, Norihiro, Schulze, Matthias B., Girotto, Giorgia, Böger, Carsten A., Jung, Bettina, Joshi, Peter K., Bennett, David A., De Jager, Philip L., Lu, Xiangfeng, Mamakou, Vasiliki, Brown, Morris, Caulfield, Mark J., Munroe, Patricia B., Guo, Xiuqing, Ciullo, Marina, Jonas, Jost B., Samani, Nilesh J., Kaprio, Jaakko, Pajukanta, Päivi, Tusié-Luna, Teresa, Aguilar-Salinas, Carlos A., Adair, Linda S., Bechayda, Sonny Augustin, de Silva, H. Janaka, Wickremasinghe, Ananda R., Krauss, Ronald M., Wu, Jer Yuarn, Zheng, Wei, Hollander, Anneke Iden, Bharadwaj, Dwaipayan, Correa, Adolfo, Wilson, James G., Lind, Lars, Heng, Chew Kiat, Nelson, Amanda E., Golightly, Yvonne M., Wilson, James F., Penninx, Brenda, Kim, Hyung Lae, Attia, John, Scott, Rodney J., Rao, D. C., Arnett, Donna K., Hunt, Steven C., Walker, Mark, Koistinen, Heikki A., Chandak, Giriraj R., Mercader, Josep M., Costanzo, Maria C., Jang, Dongkeun, Burtt, Noël P., Villalpando, Clicerio Gonzalez, Orozco, Lorena, Fornage, Myriam, Tai, EShyong S., van Dam, Rob M., Lehtimäki, Terho, Chaturvedi, Nish, Yokota, Mitsuhiro, Liu, Jianjun, Reilly, Dermot F., McKnight, Amy Jayne, Kee, Frank, Jöckel, Karl Heinz, McCarthy, Mark I., Palmer, Colin N.A., Vitart, Veronique, Hayward, Caroline, Simonsick, Eleanor, van Duijn, Cornelia M., Jin, Zi Bing, Qu, Jia, Hishigaki, Haretsugu, Lin, Xu, März, Winfried, Gudnason, Vilmundur, Tardif, Jean Claude, Lettre, Guillaume, Hart, Leen M.‘t, Elders, Petra J.M., Damrauer, Scott M., Kumari, Meena, Kivimaki, Mika, van der Harst, Pim, Spector, Tim D., Loos, Ruth J.F., Province, Michael A., Parra, Esteban J., Cruz, Miguel, Psaty, Bruce M., Brandslund, Ivan, Pramstaller, Peter P., Rotimi, Charles N., Christensen, Kaare, Ripatti, Samuli, Widén, Elisabeth, Hakonarson, Hakon, Grant, Struan F.A., Kiemeney, Lambertus A.L.M., de Graaf, Jacqueline, Loeffler, Markus, Kronenberg, Florian, Gu, Dongfeng, Erdmann, Jeanette, Schunkert, Heribert, Franks, Paul W., Linneberg, Allan, Jukema, J. Wouter, Khera, Amit V., Männikkö, Minna, Jarvelin, Marjo Riitta, Kutalik, Zoltan, Francesco, Cucca, Mook-Kanamori, Dennis O., van Dijk, Ko Willems, Watkins, Hugh, Strachan, David P., Grarup, Niels, Sever, Peter, Poulter, Neil, Chuang, Lee Ming, Rotter, Jerome I., Dantoft, Thomas M., Karpe, Fredrik, Neville, Matt J., Timpson, Nicholas J., Cheng, Ching Yu, Wong, Tien Yin, Khor, Chiea Chuen, Li, Hengtong, Sabanayagam, Charumathi, Peters, Annette, Gieger, Christian, Hattersley, Andrew T., Pedersen, Nancy L., Magnusson, Patrik K.E., Boomsma, Dorret I., Willemsen, Allegonda H.M., Cupples, LAdrienne A., van Meurs, Joyce B.J., Ghanbari, Mohsen, Gordon-Larsen, Penny, Huang, Wei, Kim, Young Jin, Tabara, Yasuharu, Wareham, Nicholas J., Langenberg, Claudia, Zeggini, Eleftheria, Kuusisto, Johanna, Laakso, Markku, Ingelsson, Erik, Abecasis, Goncalo, Chambers, John C., Kooner, Jaspal S., de Vries, Paul S., Morrison, Alanna C., Hazelhurst, Scott, Ramsay, Michèle, North, Kari E., Daviglus, Martha, Kraft, Peter, Martin, Nicholas G., Whitfield, John B., Abbas, Shahid, Saleheen, Danish, Walters, Robin G., Holmes, Michael V., Black, Corri, Smith, Blair H., Baras, Aris, Justice, Anne E., Buring, Julie E., Ridker, Paul M., Chasman, Daniel I., Kooperberg, Charles, Tamiya, Gen, Yamamoto, Masayuki, van Heel, David A., Trembath, Richard C., Wei, Wei Qi, Jarvik, Gail P., Namjou, Bahram, Hayes, M. Geoffrey, Ritchie, Marylyn D., Jousilahti, Pekka, Salomaa, Veikko, Hveem, Kristian, Åsvold, Bjørn Olav, Kubo, Michiaki, Kamatani, Yoichiro, Okada, Yukinori, Murakami, Yoshinori, Kim, Bong Jo, Thorsteinsdottir, Unnur, Stefansson, Kari, Zhang, Jifeng, Chen, YEugene E., Ho, Yuk Lam, Lynch, Julie A., Rader, Daniel J., Tsao, Philip S., Chang, Kyong Mi, Cho, Kelly, O’Donnell, Christopher J., Gaziano, John M., Wilson, Peter W.F., Frayling, Timothy M., Hirschhorn, Joel N., Kathiresan, Sekar, Mohlke, Karen L., Sun, Yan V., Morris, Andrew P., Boehnke, Michael, Brown, Christopher D., Natarajan, Pradeep, Deloukas, Panos, Willer, Cristen J., Assimes, Themistocles L., Peloso, Gina M.

المساهمون: Medicum, Institute for Molecular Medicine Finland, Complex Disease Genetics, Samuli Olli Ripatti / Principal Investigator, HUSLAB, Epigenetics of Complex Diseases and Traits, Department of Medicine, Helsinki University Hospital Area, Centre of Excellence in Complex Disease Genetics, Department of Public Health, Faculty Common Matters (Faculty of Social Sciences), Elisabeth Ingrid Maria Widen / Principal Investigator, Genomic Discoveries and Clinical Translation

مصطلحات موضوعية: Cholesterol, Genetics, Genome-wide association study, GWAS, Lipids, 1184 Genetics, developmental biology, physiology, 3142 Public health care science, environmental and occupational health, 3141 Health care science, 112 Statistics and probability

وصف الملف: application/pdf

العلاقة: GMP, PN, and CW are supported by NHLBI R01HL127564. GMP and PN are supported by R01HL142711. AG acknowledge support from the Wellcome Trust (201543/B/16/Z), European Union Seventh Framework Programme FP7/2007–2013 under grant agreement no. HEALTH-F2-2013–601456 (CVGenes@Target) & the TriPartite Immunometabolism Consortium [TrIC]-Novo Nordisk Foundation’s Grant number NNF15CC0018486. JMM is supported by American Diabetes Association Innovative and Clinical Translational Award 1–19-ICTS-068. SR was supported by the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant No 312062), the Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, and University of Helsinki HiLIFE Fellow and Grand Challenge grants. EW was supported by the Finnish innovation fund Sitra (EW) and Finska Läkaresällskapet. CNS was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016. Charles N Rotimi is supported by Z01HG200362. Zhe Wang, Michael H Preuss, and Ruth JF Loos are supported by R01HL142302. NJT is a Wellcome Trust Investigator (202802/Z/16/Z), is the PI of the Avon Longitudinal Study of Parents and Children (MRC & WT 217065/Z/19/Z), is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215–2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011), and works within the CRUK Integrative Cancer Epidemiology Programme (C18281/A19169). Ruth E Mitchell is a member of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the MRC (MC_UU_00011/1). Simon Haworth is supported by the UK National Institute for Health Research Academic Clinical Fellowship. Paul S. de Vries was supported by American Heart Association grant number 18CDA34110116. Julia Ramierz acknowledges support by the People Programme of the European Union’s Seventh Framework Programme grant n° 608765 and Marie Sklodowska-Curie grant n° 786833. Maria Sabater-Lleal is supported by a Miguel Servet contract from the ISCIII Spanish Health Institute (CP17/00142) and co-financed by the European Social Fund. Jian Yang is funded by the Westlake Education Foundation. Olga Giannakopoulou has received funding from the British Heart Foundation (BHF) (FS/14/66/3129). CHARGE Consortium cohorts were supported by R01HL105756. Study-specific acknowledgements are available in the Additional file : Supplementary Note. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.; Kanoni , S , Graham , S E , Wang , Y , Surakka , I , Ramdas , S , Zhu , X , Clarke , S L , Bhatti , K F , Vedantam , S , Winkler , T W , Locke , A E , Marouli , E , Zajac , G J M , Wu , K H H , Ntalla , I , Hui , Q , Klarin , D , Hilliard , A T , Wang , Z , Xue , C , Thorleifsson , G , Helgadottir , A , Gudbjartsson , D F , Holm , H , Olafsson , I , Hwang , M Y , Han , S , Akiyama , M , Sakaue , S , Terao , C , Kanai , M , Zhou , W , Brumpton , B M , Rasheed , H , Havulinna , A S , Veturi , Y , Pacheco , J A , Rosenthal , E A , Lingren , T , Feng , Q P , Kullo , I J , Narita , A , Takayama , J , Martin , H C , Hunt , K A , Trivedi , B , Haessler , J , Giulianini , F , Bradford , Y , Miller , J E , Campbell , A , Lin , K , Millwood , I Y , Rasheed , A , Hindy , G , Faul , J D , Zhao , W , Weir , D R , Turman , C , Huang , H , Graff , M , Choudhury , A , Sengupta , D , Mahajan , A , Brown , M R , Zhang , W , Yu , K , Schmidt , E M , Pandit , A , Gustafsson , S , Yin , X , Luan , J , Zhao , J H , Matsuda , F , Jang , H M , Yoon , K , Medina-Gomez , C , Pitsillides , A , Hottenga , J J , Wood , A R , Ji , Y , Gao , Z , Haworth , S , Yousri , N A , Mitchell , R E , Chai , J F , Aadahl , M , Bjerregaard , A A , Yao , J , Manichaikul , A , Hwu , C M , Hung , Y J , Warren , H R , Ramirez , J , Bork-Jensen , J , Kårhus , L L , Goel , A , Sabater-Lleal , M , Noordam , R , Mauro , P , Matteo , F , McDaid , A F , Marques-Vidal , P , Wielscher , M , Trompet , S , Sattar , N , Møllehave , L T , Munz , M , Zeng , L , Huang , J , Yang , B , Poveda , A , Kurbasic , A , Lamina , C , Forer , L , Scholz , M , Galesloot , T E , Bradfield , J P , Ruotsalainen , S E , Daw , EW W , Zmuda , J M , Mitchell , J S , Fuchsberger , C , Christensen , H , Brody , J A , Vazquez-Moreno , M , Feitosa , M F , Wojczynski , M K , Wang , Z , Preuss , M H , Mangino , M , Christofidou , P , Verweij , N , Benjamins , J W , Engmann , J , Tsao , N L , Verma , A , Slieker , R C , Lo , K S , Zilhao , N R , Le , P , Kleber , M E , Delgado , G E , Huo , S , Ikeda , D D , Iha , H , Yang , J , Liu , J , Demirkan , A , Leonard , H L , Marten , J , Frank , M , Schmidt , B , Smyth , L J , Cañadas-Garre , M , Wang , C , Nakatochi , M , Wong , A , Hutri-Kähönen , N , Sim , X , Xia , R , Huerta-Chagoya , A , Fernandez-Lopez , J C , Lyssenko , V , Nongmaithem , S S , Bayyana , S , Stringham , H M , Irvin , M R , Oldmeadow , C , Kim , H N , Ryu , S , Timmers , P R H J , Arbeeva , L , Dorajoo , R , Lange , L A , Prasad , G , Lorés-Motta , L , Pauper , M , Long , J , Li , X , Theusch , E , Takeuchi , F , Spracklen , C N , Loukola , A , Bollepalli , S , Warner , S C , Wang , Y X , Wei , W B , Nutile , T , Ruggiero , D , Sung , Y J , Chen , S , Liu , F , Yang , J , Kentistou , K A , Banas , B , Nardone , G G , Meidtner , K , Bielak , L F , Smith , J A , Hebbar , P , Farmaki , A E , Hofer , E , Lin , M , Concas , M P , Vaccargiu , S , van der Most , P J , Pitkänen , N , Cade , B E , van der Laan , S W , Chitrala , K N , Weiss , S , Bentley , A R , Doumatey , A P , Adeyemo , A A , Lee , J Y , Petersen , E R B , Nielsen , A A , Choi , H S , Nethander , M , Freitag-Wolf , S , Southam , L , Rayner , N W , Wang , C A , Lin , S Y , Wang , J S , Couture , C , Lyytikäinen , L P , Nikus , K , Cuellar-Partida , G , Vestergaard , H , Hidalgo , B , Giannakopoulou , O , Cai , Q , Obura , M O , van Setten , J , Li , X , Liang , J , Tang , H , Terzikhan , N , Shin , J H , Jackson , R D , Reiner , A P , Martin , L W , Chen , Z , Li , L , Kawaguchi , T , Thiery , J , Bis , J C , Launer , L J , Li , H , Nalls , M A , Raitakari , O T , Ichihara , S , Wild , S H , Nelson , C P , Campbell , H , Jäger , S , Nabika , T , Al-Mulla , F , Niinikoski , H , Braund , P S , Kolcic , I , Kovacs , P , Giardoglou , T , Katsuya , T , de Kleijn , D , de Borst , G J , Kim , E K , Adams , H H H , Ikram , M A , Zhu , X , Asselbergs , F W , Kraaijeveld , A O , Beulens , J W J , Shu , X O , Rallidis , L S , Pedersen , O , Hansen , T , Mitchell , P , Hewitt , A W , Kähönen , M , Pérusse , L , Bouchard , C , Tönjes , A , Chen , Y D I , Pennell , C E , Mori , T A , Lieb , W , Franke , A , Ohlsson , C , Mellström , D , Cho , Y S , Lee , H , Yuan , J M , Koh , W P , Rhee , S Y , Woo , J T , Heid , I M , Stark , K J , Zimmermann , M E , Völzke , H , Homuth , G , Evans , M K , Zonderman , A B , Polasek , O , Pasterkamp , G , Hoefer , I E , Redline , S , Pahkala , K , Oldehinkel , A J , Snieder , H , Biino , G , Schmidt , R , Schmidt , H , Bandinelli , S , Dedoussis , G , Thanaraj , T A , Kardia , S L R , Peyser , P A , Kato , N , Schulze , M B , Girotto , G , Böger , C A , Jung , B , Joshi , P K , Bennett , D A , De Jager , P L , Lu , X , Mamakou , V , Brown , M , Caulfield , M J , Munroe , P B , Guo , X , Ciullo , M , Jonas , J B , Samani , N J , Kaprio , J , Pajukanta , P , Tusié-Luna , T , Aguilar-Salinas , C A , Adair , L S , Bechayda , S A , de Silva , H J , Wickremasinghe , A R , Krauss , R M , Wu , J Y , Zheng , W , Hollander , A I , Bharadwaj , D , Correa , A , Wilson , J G , Lind , L , Heng , C K , Nelson , A E , Golightly , Y M , Wilson , J F , Penninx , B , Kim , H L , Attia , J , Scott , R J , Rao , D C , Arnett , D K , Hunt , S C , Walker , M , Koistinen , H A , Chandak , G R , Mercader , J M , Costanzo , M C , Jang , D , Burtt , N P , Villalpando , C G , Orozco , L , Fornage , M , Tai , ES S , van Dam , R M , Lehtimäki , T , Chaturvedi , N , Yokota , M , Liu , J , Reilly , D F , McKnight , A J , Kee , F , Jöckel , K H , McCarthy , M I , Palmer , C N A , Vitart , V , Hayward , C , Simonsick , E , van Duijn , C M , Jin , Z B , Qu , J , Hishigaki , H , Lin , X , März , W , Gudnason , V , Tardif , J C , Lettre , G , Hart , L M , Elders , P J M , Damrauer , S M , Kumari , M , Kivimaki , M , van der Harst , P , Spector , T D , Loos , R J F , Province , M A , Parra , E J , Cruz , M , Psaty , B M , Brandslund , I , Pramstaller , P P , Rotimi , C N , Christensen , K , Ripatti , S , Widén , E , Hakonarson , H , Grant , S F A , Kiemeney , L A L M , de Graaf , J , Loeffler , M , Kronenberg , F , Gu , D , Erdmann , J , Schunkert , H , Franks , P W , Linneberg , A , Jukema , J W , Khera , A V , Männikkö , M , Jarvelin , M R , Kutalik , Z , Francesco , C , Mook-Kanamori , D O , van Dijk , K W , Watkins , H , Strachan , D P , Grarup , N , Sever , P , Poulter , N , Chuang , L M , Rotter , J I , Dantoft , T M , Karpe , F , Neville , M J , Timpson , N J , Cheng , C Y , Wong , T Y , Khor , C C , Li , H , Sabanayagam , C , Peters , A , Gieger , C , Hattersley , A T , Pedersen , N L , Magnusson , P K E , Boomsma , D I , Willemsen , A H M , Cupples , LA A , van Meurs , J B J , Ghanbari , M , Gordon-Larsen , P , Huang , W , Kim , Y J , Tabara , Y , Wareham , N J , Langenberg , C , Zeggini , E , Kuusisto , J , Laakso , M , Ingelsson , E , Abecasis , G , Chambers , J C , Kooner , J S , de Vries , P S , Morrison , A C , Hazelhurst , S , Ramsay , M , North , K E , Daviglus , M , Kraft , P , Martin , N G , Whitfield , J B , Abbas , S , Saleheen , D , Walters , R G , Holmes , M V , Black , C , Smith , B H , Baras , A , Justice , A E , Buring , J E , Ridker , P M , Chasman , D I , Kooperberg , C , Tamiya , G , Yamamoto , M , van Heel , D A , Trembath , R C , Wei , W Q , Jarvik , G P , Namjou , B , Hayes , M G , Ritchie , M D , Jousilahti , P , Salomaa , V , Hveem , K , Åsvold , B O , Kubo , M , Kamatani , Y , Okada , Y , Murakami , Y , Kim , B J , Thorsteinsdottir , U , Stefansson , K , Zhang , J , Chen , YE E , Ho , Y L , Lynch , J A , Rader , D J , Tsao , P S , Chang , K M , Cho , K , O’Donnell , C J , Gaziano , J M , Wilson , P W F , Frayling , T M , Hirschhorn , J N , Kathiresan , S , Mohlke , K L , Sun , Y V , Morris , A P , Boehnke , M , Brown , C D , Natarajan , P , Deloukas , P , Willer , C J , Assimes , T L & Peloso , G M 2022 , ' Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis ' , Genome Biology , vol. 23 , no. 1 , 268 . https://doi.org/10.1186/s13059-022-02837-1Test; ORCID: /0000-0001-7870-070X/work/130600781; ORCID: /0000-0003-0542-5967/work/130601174; ORCID: /0000-0002-8773-7149/work/130605566; 85144774123; 73609295-cdc2-4438-a33f-d480ed37cb6d; http://hdl.handle.net/10138/355889Test

الإتاحة: http://hdl.handle.net/10138/355889Test

المؤلفون: McDonough, Caitrin W., Warren, Helen R., Jack, John R., Motsinger-Reif, Alison A., Armstrong, Nicole D., Bis, Joshua C., House, John S., Singh, Sonal, El Rouby, Nihal M., Gong, Yan, Mychaleckyj, Joesyf C., Rotroff, Daniel M., Benavente, Oscar R., Caulfield, Mark J., Doria, Alessandrio, Pepine, Carl J., Psaty, Bruce M., Glorioso, Valeria, Glorioso, Nicola, Hiltunen, Timo P., Kontula, Kimmo K., Arnett, Donna K., Buse, John B., Irvin, Marguerite R., Johnson, Julie A., Munroe, Patricia B., Wagner, Michael J., Cooper-DeHoff, Rhonda M.

المساهمون: HUS Internal Medicine and Rehabilitation, Kimmo Kontula Research Group, Clinicum, Department of Medicine, CAMM - Research Program for Clinical and Molecular Metabolism

مصطلحات موضوعية: CORONARY-ARTERY-DISEASE, BLOOD-PRESSURE, GENE POLYMORPHISMS, ASSOCIATION, RISK, HYPERTENSION, PREVENTION, DESIGN, TRIAL, RATIONALE, 317 Pharmacy

وصف الملف: application/pdf

العلاقة: C.W. M. is supported by National Institutes of Health (NIH) grant K01 HL141690. ASCOT was funded by the National Institutes for Health Research (NIHR) as part of the portfolio of translational research of the NIHR Barts Biomedical Research Unit and the NIHR Biomedical Research Centre at Imperial College, the International Centre for Circulatory Health Charity, and the Medical Research Council through G952010. ACCORD research was supported by NIH grants R01 HL110380 and R01 HL110400, and intramural funds from the National Institute of Environmental Health Sciences. ACCORD cohort was supported by Contract Nos. N01-HC-95178, N01-HC-95179, N01-HC-95180, N01-HC-95181, N01-HC-95182, N01-HC-95183, N01-HC-95184, IAA #Y1-HC-9035, and IAA #Y1-HC-1010 from the National Heart, Lung, and Blood Institute (NHLBI), with additional support from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Eye Institute (NEI), the National Institute on Aging (NIA), and the Centers for Disease Control and Prevention (CDC). INVEST was supported by the NIH grants R01 HL074730, U01 GM074492, and NIH CTSA grant UL1 RR092890, as well as grants from the University of Florida Opportunity Fund and Abbott Pharmaceuticals. The genome-wide genotyping for INVEST--GENES was provided by RIKEN. SPS3 was supported by NIH grants R01 NS073346, U01 GM074492-05S109, and U01 NS038529. Infrastructure for the CHARGE Consortium and the CHARGE Pharmacogenetics Working Group is supported in part by the NHLBI grants R01 HL105756, R01 HL103612, and R01 HL085251, and CHS contract number 75N92021D00006. Study descriptions and acknowledgements for the participating CHARGE cohorts are available in https://doi.org/10.1371/journal.pone.0140496.BothTest the PEAR and PEAR-2 studies were supported by NIH grants U01-GM074492 and UL1 TR000064 (University of Florida); UL1 TR000454 (Emory University), and UL1 TR000135 (Mayo Clinic). PEAR was also supported by funds from the Mayo Foundation. LIFE-Fin and GENRES were supported by the Sigrid Juselius Foundation, The Finnish Foundation for Cardiovascular Research, and the Helsinki University Central Hospital. BB-SS studies were supported by the HYPERGENES project (FP7-HEALTHF4-2007-201550), InterOmics (PB05 MIUR--CNR Italian Flagship Project), and the "Associazione per lo sviluppo della ricerca sull'ipertensione arteriosa e sulle malattie cardiovascolari-ONLUS." GenHAT was supported by NIH grants R01 HL123782 and R01 HL063082, and N.A. was also supported by NIH grant T32 HL007457.; McDonough , C W , Warren , H R , Jack , J R , Motsinger-Reif , A A , Armstrong , N D , Bis , J C , House , J S , Singh , S , El Rouby , N M , Gong , Y , Mychaleckyj , J C , Rotroff , D M , Benavente , O R , Caulfield , M J , Doria , A , Pepine , C J , Psaty , B M , Glorioso , V , Glorioso , N , Hiltunen , T P , Kontula , K K , Arnett , D K , Buse , J B , Irvin , M R , Johnson , J A , Munroe , P B , Wagner , M J & Cooper-DeHoff , R M 2021 , ' Adverse Cardiovascular Outcomes and Antihypertensive Treatment : A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies ' , Clinical Pharmacology and Therapeutics , vol. 110 , no. 3 , pp. 723-732 . https://doi.org/10.1002/cpt.2355Test; ORCID: /0000-0001-7011-0422/work/100975867; d3361e4a-c6e4-44c7-9645-be4f6ab33ebb; http://hdl.handle.net/10138/568320Test; 000684936700001

الإتاحة: https://doi.org/10.1371/journal.pone.0140496.BothTest
http://hdl.handle.net/10138/568320Test

المؤلفون: Zhang, Xinruo, Brody, Jennifer A., Graff, Mariaelisa, Highland, Heather M., Chami, Nathalie, Xu, Hanfei, Wang, Zhe, Ferrier, Kendra, Chittoor, Geetha, Josyula, Navya S., Li, Xihao, Li, Zilin, Allison, Matthew A., Becker, Diane M., Bielak, Lawrence F., Bis, Joshua C., Boorgula, Meher Preethi, Bowden, Donald W., Broome, Jai G., Buth, Erin J., Carlson, Christopher S., Chang, Kyong-Mi, Chavan, Sameer, Chiu, Yen-Feng, Chuang, Lee-Ming, Conomos, Matthew P., DeMeo, Dawn L., Du, Margaret, Duggirala, Ravindranath, Eng, Celeste, Fohner, Alison E., Freedman, Barry I., Garrett, Melanie E., Guo, Xiuqing, Haiman, Chris, Heavner, Benjamin D., Hidalgo, Bertha, Hixson, James E., Ho, Yuk-Lam, Hobbs, Brian D., Hu, Donglei, Hui, Qin, Hwu, Chii-Min, Jackson, Rebecca D., Jain, Deepti, Kalyani, Rita R., Kardia, Sharon L. R., Kelly, Tanika N., Lange, Ethan M., LeNoir, Michael, Li, Changwei, Marchand, Loic Le, McDonald, Merry-Lynn N., McHugh, Caitlin P., Morrison, Alanna C., Naseri, Take, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, O'Connell, Jeffrey, O'Donnell, Christopher J., Palmer, Nicholette D., Pankow, James S., Perry, James A., Peters, Ulrike, Preuss, Michael H., Rao, D. C., Regan, Elizabeth A., Reupena, Sefuiva M., Roden, Dan M., Rodriguez-Santana, Jose, Sitlani, Colleen M., Smith, Jennifer A., Tiwari, Hemant K., Vasan, Ramachandran S., Wang, Zeyuan, Weeks, Daniel E., Wessel, Jennifer, Wiggins, Kerri L., Wilkens, Lynne R., Wilson, Peter W. F., Yanek, Lisa R., Yoneda, Zachary T., Zhao, Wei, Zöllner, Sebastian, Arnett, Donna K., Ashley-Koch, Allison E., Barnes, Kathleen C., Blangero, John, Boerwinkle, Eric, Burchard, Esteban G., Carson, April P., Chasman, Daniel I., Chen, Yii-Der Ida, Curran, Joanne E., Fornage, Myriam, Gordeuk, Victor R., He, Jiang, Heckbert, Susan R., Hou, Lifang, Irvin, Marguerite R., Kooperberg, Charles, Minster, Ryan L., Mitchell, Braxton D., Nouraie, Mehdi, Psaty, Bruce M., Raffield, Laura M., Reiner, Alexander P., Rich, Stephen S., Rotter, Jerome I., Shoemaker, M. Benjamin, Smith, Nicholas L., Taylor, Kent D., Telen, Marilyn J., Weiss, Scott T., Zhang, Yingze, Heard-Costa, Nancy, Sun, Yan V., Lin, Xihong, Cupples, L. Adrienne, Lange, Leslie A., Liu, Ching-Ti, Loos, Ruth J. F., North, Kari E., Justice, Anne E.

المساهمون: Biostatistics and Health Data Science, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Obesity, Mortality, Body mass index (BMI), Personalized medicine

وصف الملف: application/pdf

العلاقة: Zhang X, Brody JA, Graff M, et al. WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE. Preprint. medRxiv. 2023;2023.08.21.23293271. Published 2023 Aug 22. doi:10.1101/2023.08.21.23293271; https://hdl.handle.net/1805/39289Test

الإتاحة: https://doi.org/10.1101/2023.08.21.23293271Test
https://hdl.handle.net/1805/39289Test