التفاصيل البيبلوغرافية
| العنوان: |
Clinical features, biochemistry and HLA-DRB1 status in youth-onset type 1 diabetes in Pakistan. |
| المؤلفون: |
Fawwad, Asher1 (AUTHOR) asherfawwad@bide.edu.pk, Govender, Denira1 (AUTHOR) dgov8678@uni.sydney.edu.au, Ahmedani, Mohammad Yakoob1 (AUTHOR) myakoob@bide.edu.pk, Basit, Abdul1 (AUTHOR) abdulbasit@bide.edu.pk, Lane, Julie Ann1 (AUTHOR) howlane@sbcglobal.net, Mack, Steven John1 (AUTHOR) sjmack@chori.org, Atkinson, Mark Alvin1 (AUTHOR) atkinson@ufl.edu, Henry Wasserfall, Clive1 (AUTHOR) clive@ufl.edu, Ogle, Graham David1 (AUTHOR) grahamo@diabetesnsw.com.au, Noble, Janelle Annette1 (AUTHOR) jnoble@chori.org |
| المصدر: |
Diabetes Research & Clinical Practice. Mar2019, Vol. 149, p9-17. 9p. |
| مصطلحات موضوعية: |
*TYPE 1 diabetes, *BIOCHEMISTRY, *GLUTAMATE decarboxylase, *DIABETES in children, *DEMOGRAPHIC characteristics, *TYPE 2 diabetes, *AUTOANTIBODIES, *C-peptide, *RESEARCH funding, *HLA-B27 antigen |
| مصطلحات جغرافية: |
PAKISTAN, KARACHI (Pakistan) |
| مستخلص: |
Published information on diabetes in Pakistani youth is limited. We aimed to investigate the demographic, clinical, and biochemical features, and HLA-DRB1 alleles in new cases of diabetes affecting children and adolescents <22 years of age. The study was conducted at Baqai Institute of Diabetology and Endocrinology in Karachi from June 2013-December 2015. One hundred subjects aged <22 years at diagnosis were enrolled. Demographic characteristics, clinical information, biochemical parameters (blood glucose, HbA1c, C-peptide, glutamic acid decarboxylase 65 (GAD65) and islet antigen 2 (IA-2) autoantibodies) were measured. DNA from 100 subjects and 200 controls was extracted and genotyped for HLA-DRB1 using high-resolution genotyping technology. Ninety-nine subjects were clinically diagnosed as type 1 diabetes (T1D) and one as type 2 diabetes (T2D). Of the 99 with T1D, 57 (57.6%) were males and 42 (42.4%) females, with mean age at diagnosis 11.0 ± 5.2 years (range 1.6-21.7 years) and peaks at six and fifteen years. Fifty-seven subjects were assessed within one month of diagnosis and all within eleven months. For the subjects diagnosed as T1D, mean C-peptide was 0.63 ± 0.51 nmol/L (1.91 ± 1.53 ng/mL), with 16 (16.2%) IA2 positive, 53 (53.5%) GAD-65 positive, and 10 (10.1%) positive for both autoantibodies. In T1D patients, the allele DRB1*03:01 demonstrated highly significant T1D association (p < 10-16), with no apparent risk conferred by DRB1*04:xx alleles. CONCLUSIONS: Heterogeneous forms of T1D appear more common in children and youth in Pakistan than in European populations. Individual understanding of such cases could enable improved management strategies and healthier outcomes. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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