التفاصيل البيبلوغرافية
| العنوان: |
Chitins and chitinase activity in airway diseases |
| المؤلفون: |
Van Dyken, Steven J, Locksley, Richard M |
| المصدر: |
Journal of Allergy and Clinical Immunology, vol 142, iss 2 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2018 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Immunology, Animals, Chitin, Chitinases, Environmental Exposure, Extinction, Biological, Homeostasis, Humans, Immunity, Mucosal, Mammals, Mice, Polysaccharides, Respiratory Tract Diseases, Acidic mammalian chitinase, age-related disease, chitotriosidase, chitinase, fibrosis, epithelium, innate lymphoid cell, interleukins, interstitial lung disease, polysaccharide, pulmonary fibrosis, Allergy |
| جغرافية الموضوع: |
364 - 369 |
| الوصف: |
Chitin, one of the most abundant biopolymers on Earth, is bound and degraded by chitinases, specialized enzymes that are similarly widespread in nature. Chitin catabolism affects global carbon and nitrogen cycles through a host of diverse biological processes, but recent work has focused attention on systems of chitin recognition and degradation conserved in mammals, connecting an ancient pathway of polysaccharide processing to human diseases influenced by persistent immune triggering. Here we review current advances in our understanding of how chitin-chitinase interactions affect mucosal immune feedback mechanisms essential to maintaining homeostasis and organ health. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt8bv6r3nn; https://escholarship.org/uc/item/8bv6r3nnTest |
| الإتاحة: |
https://escholarship.org/uc/item/8bv6r3nnTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.2D82E9B5 |
| قاعدة البيانات: |
BASE |
