التفاصيل البيبلوغرافية
| العنوان: |
Digoxin and 30-day All-cause Hospital Admission in Older Patients with Chronic Diastolic Heart Failure |
| المؤلفون: |
Hashim, Taimoor, Elbaz, Shereen, Patel, Kanan, Morgan, Charity J, Fonarow, Gregg C, Fleg, Jerome L, McGwin, Gerald, Cutter, Gary R, Allman, Richard M, Prabhu, Sumanth D, Zile, Michael R, Bourge, Robert C, Ahmed, Ali |
| المصدر: |
The American Journal of Medicine, vol 127, iss 2 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2014 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Aging, Cardiovascular, Clinical Research, Clinical Trials and Supportive Activities, Heart Disease, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Aged, 80 and over, Canada, Cardiotonic Agents, Cardiovascular Agents, Chronic Disease, Digoxin, Double-Blind Method, Female, Follow-Up Studies, Heart Failure, Diastolic, Humans, Kaplan-Meier Estimate, Male, Odds Ratio, Patient Admission, Patient Readmission, Proportional Hazards Models, Sample Size, Treatment Outcome, United States, Diastolic heart failure |
| جغرافية الموضوع: |
132 - 139 |
| الوصف: |
BackgroundIn the main Digitalis Investigation Group (DIG) trial, digoxin reduced the risk of 30-day all-cause hospitalization in older systolic heart failure patients. However, this effect has not been studied in older diastolic heart failure patients.MethodsIn the ancillary DIG trial, of the 988 patients with chronic heart failure and preserved (> 45%) ejection fraction, 631 were age ≥ 65 years (mean age 73 years, 45% women, 12% non-whites), of whom 311 received digoxin.ResultsAll-cause hospitalization 30-day post randomization occurred in 4% of patients in the placebo group and 9% each among those in the digoxin group receiving 0.125 mg and ≥ 0.25 mg a day dosage (P = .026). Hazard ratios (HR) and 95% confidence intervals (CI) for digoxin use overall for 30-day, 3-month, and 12-month all-cause hospitalizations were 2.46 (1.25-4.83), 1.45 (0.96-2.20) and 1.14 (0.89-1.46), respectively. There was one 30-day death in the placebo group. Digoxin-associated HRs (95% CIs) for 30-day hospitalizations due to cardiovascular, heart failure, and unstable angina causes were 2.82 (1.18-6.69), 0.51 (0.09-2.79), and 6.21 (0.75-51.62), respectively. Digoxin had no significant association with 30-day all-cause hospitalization among younger patients (6% vs 7% for placebo; HR 0.80; 95% CI, 0.36-1.79).ConclusionsIn older patients with chronic diastolic heart failure, digoxin increased the risk of 30-day all-cause hospital admission, but not during longer follow-up. Although chance finding due to small sample size is possible, these data suggest that unlike in systolic heart failure, digoxin may not reduce 30-day all-cause hospitalization in older diastolic heart failure patients. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt1j4848z3; https://escholarship.org/uc/item/1j4848z3Test |
| الإتاحة: |
https://escholarship.org/uc/item/1j4848z3Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.75DCBBE3 |
| قاعدة البيانات: |
BASE |
