المؤلفون: Bettaieb, Ahmed, Bakke, Jesse, Nagata, Naoto, Matsuo, Kosuke, Xi, Yannan, Liu, Siming, AbouBechara, Daniel, Melhem, Ramzi, Stanhope, Kimber, Cummings, Bethany, Graham, James, Bremer, Andrew, Zhang, Sheng, Lyssiotis, Costas A, Zhang, Zhong-Yin, Cantley, Lewis C, Havel, Peter J, Haj, Fawaz G

المصدر: Journal of Biological Chemistry. 288(24)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Diabetes, Obesity, Nutrition, Underpinning research, 1.1 Normal biological development and functioning, Metabolic and endocrine, 3T3-L1 Cells, Adipose Tissue, Brown, Adult, Aged, Amino Acid Substitution, Animals, Diet, High-Fat, Energy Metabolism, Gene Knockdown Techniques, Glucose Intolerance, Humans, Insulin Resistance, Macaca mulatta, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Middle Aged, Phosphorylation, Phosphotyrosine, Protein Interaction Domains and Motifs, Protein Interaction Mapping, Protein Processing, Post-Translational, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Pyruvate Kinase, Signal Transduction, Adipocyte, Metabolism, Tyrosine Protein Phosphatase, Chemical Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9kk0r72cTest

المؤلفون: Anastasiou, Dimitrios, Yu, Yimin, Israelsen, William J, Jiang, Jian-Kang, Boxer, Matthew B, Hong, Bum Soo, Tempel, Wolfram, Dimov, Svetoslav, Shen, Min, Jha, Abhishek, Yang, Hua, Mattaini, Katherine R, Metallo, Christian M, Fiske, Brian P, Courtney, Kevin D, Malstrom, Scott, Khan, Tahsin M, Kung, Charles, Skoumbourdis, Amanda P, Veith, Henrike, Southall, Noel, Walsh, Martin J, Brimacombe, Kyle R, Leister, William, Lunt, Sophia Y, Johnson, Zachary R, Yen, Katharine E, Kunii, Kaiko, Davidson, Shawn M, Christofk, Heather R, Austin, Christopher P, Inglese, James, Harris, Marian H, Asara, John M, Stephanopoulos, Gregory, Salituro, Francesco G, Jin, Shengfang, Dang, Lenny, Auld, Douglas S, Park, Hee-Won, Cantley, Lewis C, Thomas, Craig J, Vander Heiden, Matthew G

المصدر: Nature Chemical Biology. 8(10)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Cancer, Animals, Biopolymers, Blotting, Western, Cell Proliferation, Cell Transformation, Neoplastic, Enzyme Activators, Humans, Mice, Neoplasms, Pyruvate Kinase, Medicinal and Biomolecular Chemistry, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/0s42k651Test

المؤلفون: Yang, Weiwei, Zheng, Yanhua, Xia, Yan, Ji, Haitao, Chen, Xiaomin, Guo, Fang, Lyssiotis, Costas A., Aldape, Kenneth, Cantley, Lewis C., Lu, Zhimin

المصدر: Nature Cell Biology; Dec2012, Vol. 14 Issue 12, p1295-1304, 10p, 6 Color Photographs, 8 Graphs

مصطلحات موضوعية: PHOSPHORYLATION, CHROMOSOMAL translocation, ISOMERIZATION, CYTOCHROME oxidase, PYRUVATE kinase, BRAIN tumors, CARCINOGENESIS

المؤلفون: Wang, Zhenxun, Chatterjee, Deblina, Jeon, Hyun Yong, Akerman, Martin, Vander Heiden, Matthew G., Cantley, Lewis C., Krainer, Adrian R.

المصدر: Journal of Molecular Cell Biology; Apr2012, Vol. 4 Issue 2, p79-87, 9p, 1 Diagram, 5 Graphs

المؤلفون: CIower, Cynthia V., Chatterjee, Deblina, Zhenxun Wang, Cantley, Lewis C., Vander-Heiden, Matthew G., Krainer, Adrian R.

المصدر: Proceedings of the National Academy of Sciences of the United States of America; 2/2/2010, Vol. 107 Issue 5, p1894-1899, 6p

مصطلحات موضوعية: CELL metabolism, RNA splicing, PYRUVATE kinase, CANCER cells, GLYCOLYSIS, MUSCLE cells, GLUCOSE synthesis

المؤلفون: Christofk, Heather R., Vander Heiden, Matthew G., Wu, Ning, Asara, John M., Cantley, Lewis C.

المصدر: Nature; 3/13/2008, Vol. 452 Issue 7184, p181-186, 6p, 1 Diagram, 4 Graphs

مصطلحات موضوعية: PYRUVATE kinase, PHOSPHOTRANSFERASES, PROTEINS, TYROSINE, ENZYMES, PEPTIDES, FRUCTOSE, DIPHOSPHONATES, METABOLITES

المؤلفون: Christofk, Heather R., Vander Heiden, Matthew G., Harris, Marian H., Ramanathan, Arvind, Gerszten, Robert E., Wei, Ru, Fleming, Mark D., Schreiber, Stuart L., Cantley, Lewis C.

المصدر: Nature; 3/13/2008, Vol. 452 Issue 7184, p230-233, 4p, 1 Color Photograph, 3 Graphs

مصطلحات موضوعية: CANCER cells, PHOSPHORYLATION, PYRUVATE kinase, GENOTYPE-environment interaction, PHOTOSYNTHETIC oxygen evolution, GLYCOLYSIS, CELL lines, MOLECULAR genetics, MOLECULAR biology

المؤلفون: Anastasiou, Dimitrios^1,2, Poulogiannis, George^1,2, Asara, John M.^1,3, Boxer, Matthew B.⁴, Jiang, Jian-kang⁴, Shen, Min⁴, Beilinger, Gary^1,5, Sasaki, Atsuo T.^1,2, Locasale, Jason W.^1,2, Auld, Douglas S.⁴, Thomas, Craig J.⁴, Vander Heiden, Matthew G.^6,7, Cantley, Lewis C.^1,2

المصدر: Science. 12/2/2011, Vol. 334 Issue 6060, p1278-1283. 6p.

مصطلحات موضوعية: *CANCER cells, *CELLULAR control mechanisms, *REACTIVE oxygen species, *PYRUVATE kinase, *CELL metabolism, *OXIDATIVE stress, *LUNG cancer

المؤلفون: Walsh, Martin J.¹, Brimacombe, Kyle R.¹, Veith, Henrike¹, Bougie, James M.¹, Daniel, Thomas¹, Leister, William¹, Cantley, Lewis C.^2,3, Israelsen, William J.⁴, Vander Heiden, Matthew G.^4,5, Shen, Min¹, Auld, Douglas S.¹, Thomas, Craig J.¹, Boxer, Matthew B.¹ boxerm@mail.nih.gov

المصدر: Bioorganic & Medicinal Chemistry Letters. Nov2011, Vol. 21 Issue 21, p6322-6327. 6p.

مصطلحات موضوعية: *PYRUVATE kinase, *SULFONAMIDES, *CANCER cells, *BIOSYNTHESIS, *METABOLIC regulation, *ENZYMES, *ANTINEOPLASTIC agents, *PHARMACEUTICAL chemistry

المؤلفون: Vander Heiden, Matthew G.^1,2,3, Locasale, Jason W.^2,3, Swanson, Kenneth D.², Sharfi, Hadar², Heffron, Greg J.⁴, Amador-Noguez, Daniel⁵, Christofk, Heather R.², Wagner, Gerhard⁴, Rabinowitz, Joshua D.⁵, Asara, John M.², Cantley, Lewis C.^2,3 lewis_cantley@hms.harvard.edu

المصدر: Science. 9/17/2010, Vol. 329 Issue 5998, p1492-1499. 8p.

مصطلحات موضوعية: *CELL proliferation, *CANCER cell growth, *CELL metabolism, *GLUCOSE, *PYRUVATE kinase, *PHOSPHOTRANSFERASES, *PHOSPHORYLATION