دورية أكاديمية
Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation
| العنوان: | Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation |
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| المؤلفون: | Barba, Carmen, Cross, Judith Helen, Braun, Kees, Cossu, Massimo, Klotz, Kerstin Alexandra, De Masi, Salvatore, Perez Jiménez, Maria Angeles, Gaily, Eija, Specchio, Nicola, Cabral, Pedro, Toulouse, Joseph, Dimova, Petia, Battaglia, Domenica, Freri, Elena, Consales, Alessandro, Cesaroni, Elisabetta, Tarta-Arsene, Oana, Gil-Nagel, Antonio, Mindruta, Ioana, Di Gennaro, Giancarlo, Giulioni, Marco, Tisdall, Martin M, Eltze, Christin, Tahir, Muhammad Zubair, Jansen, Floor, van Rijen, Peter, Sanders, Maurits, Tassi, Laura, Francione, Stefano, Lo Russo, Giorgio, Jacobs, Julia, Bast, Thomas, Matta, Giulia, Budke, Marcelo, Fournier Del Castillo, Concepción, Metsahonkala, Eeva-Liisa, Karppinen, Atte, Ferreira, José Carlos, Minkin, Krasimir, Marras, Carlo Efisio, Jacques, Tom, Varadkar, Sophia, Colon, Albert, D'Orio, Piergiorgio, Pelliccia, Veronica, Schulze-Bonhage, Andreas, Syrbe, Steffen, Buccoliero, Annamaria, Giordano, Flavio, García-Fernandez, Marta, Villarejo, Francisco, De Palma, Luca, Carfì Pavia, Giusy, Canas, Nuno M, Santos, Alexandra, Montavont, Alexandra, Ostrowsky-Coste, Karine, Gabrovski, Kaloyan, Stoyanova, Denitza, Tamburrini, Giampiero, Granata, Tiziana, Pacetti, Mattia, Matricardi, Sara, Craiu, Dana, Aledo, Angel, Popa, Irina, Esposito, Vincenzo, Lucenteforte, Ersilia, Arzimanoglou, Alexis, Guerrini, Renzo |
| المساهمون: | Barba, Carmen, Cross, Judith Helen, Braun, Kee, Cossu, Massimo, Klotz, Kerstin Alexandra, De Masi, Salvatore, Perez Jiménez, Maria Angele, Gaily, Eija, Specchio, Nicola, Cabral, Pedro, Toulouse, Joseph, Dimova, Petia, Battaglia, Domenica, Freri, Elena, Consales, Alessandro, Cesaroni, Elisabetta, Tarta-Arsene, Oana, Gil-Nagel, Antonio, Mindruta, Ioana, Di Gennaro, Giancarlo, Giulioni, Marco, Tisdall, Martin M, Eltze, Christin, Tahir, Muhammad Zubair, Jansen, Floor, van Rijen, Peter, Sanders, Maurit, Tassi, Laura, Francione, Stefano, Lo Russo, Giorgio, Jacobs, Julia, Bast, Thoma, Matta, Giulia, Budke, Marcelo, Fournier Del Castillo, Concepción, Metsahonkala, Eeva-Liisa, Karppinen, Atte, Ferreira, José Carlo, Minkin, Krasimir, Marras, Carlo Efisio, Jacques, Tom, Varadkar, Sophia, Colon, Albert, D'Orio, Piergiorgio, Pelliccia, Veronica, Schulze-Bonhage, Andrea, Syrbe, Steffen, Buccoliero, Annamaria, Giordano, Flavio, García-Fernandez, Marta, Villarejo, Francisco, De Palma, Luca, Carfì Pavia, Giusy, Canas, Nuno M, Santos, Alexandra, Montavont, Alexandra, Ostrowsky-Coste, Karine, Gabrovski, Kaloyan, Stoyanova, Denitza, Tamburrini, Giampiero, Granata, Tiziana, Pacetti, Mattia, Matricardi, Sara, Craiu, Dana, Aledo, Angel, Popa, Irina, Esposito, Vincenzo, Lucenteforte, Ersilia, Arzimanoglou, Alexi, Guerrini, Renzo |
| سنة النشر: | 2020 |
| المجموعة: | ARUd'A - Archivio Istituzionale della ricerca dell'università Chieti-Pescara (IRIS) |
| مصطلحات موضوعية: | children, epilepsy surgery, histopathology, outcome, survey |
| الوصف: | Objective: To profile European trends in pediatric epilepsy surgery (<16 years of age) between 2008 and 2015. Methods: We collected information on volumes and types of surgery, pathology, and seizure outcome from 20 recognized epilepsy surgery reference centers in 10 European countries. Results: We analyzed retrospective aggregate data on 1859 operations. The proportion of surgeries significantly increased over time (P < .0001). Engel class I outcome was achieved in 69.3% of children, with no significant improvement between 2008 and 2015. The proportion of histopathological findings consistent with glial scars significantly increased between the ages of 7 and 16 years (P for trend = .0033), whereas that of the remaining pathologies did not vary across ages. A significant increase in unilobar extratemporal surgeries (P for trend = .0047) and a significant decrease in unilobar temporal surgeries (P for trend = .0030) were observed between 2008 and 2015. Conversely, the proportion of multilobar surgeries and unrevealing magnetic resonance imaging cases remained unchanged. Invasive investigations significantly increased, especially stereo-electroencephalography. We found different trends comparing centers starting their activity in the 1990s to those whose programs were developed in the past decade. Multivariate analysis revealed a significant variability of the proportion of the different pathologies and surgical approaches across countries, centers, and age groups between 2008 and 2015. Significance: Between 2008 and 2015, we observed a significant increase in the volume of pediatric epilepsy surgeries, stability in the proportion of Engel class I outcomes, and a modest increment in complexity of the procedures. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31876960; info:eu-repo/semantics/altIdentifier/wos/WOS:000504373100001; volume:61; issue:2; firstpage:216; lastpage:227; numberofpages:12; journal:EPILEPSIA; https://hdl.handle.net/11564/804452Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85077375830 |
| DOI: | 10.1111/epi.16414 |
| الإتاحة: | https://doi.org/10.1111/epi.16414Test https://hdl.handle.net/11564/804452Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.AC054CD0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/epi.16414 |
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