يعرض 1 - 10 نتائج من 314 نتيجة بحث عن '"checkpoint kinase 2"', وقت الاستعلام: 0.78s تنقيح النتائج
  1. 1
    Genetic Predictors of Malignancy: a Literature Review

    المؤلفون: A. V. Pushkarev, M. G. Galeev, V. A. Pushkarev, A. V. Sultanbaev

    المصدر: Креативная хирургия и онкология, Vol 11, Iss 2, Pp 157-165 (2021)

    مصطلحات موضوعية: 0301 basic medicine, Genome instability, RD1-811, DNA repair, Biology, malignant neoplasms, medicine.disease_cause, 03 medical and health sciences, brca2 gene, 0302 clinical medicine, Germline mutation, patched-1 receptor, medicine, skin and connective tissue diseases, CHEK2, RC254-282, checkpoint kinase 2, Point mutation, brca1 gene, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cancer, neoplastic genes, General Medicine, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, germline mutations, Surgery, Carcinogenesis, Ovarian cancer, carcinogenesis

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27f2c226d2b151c04fcf0078d487998Test
    https://doi.org/10.24060/2076-3093-2021-11Test-2-157-165


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  2. 2
    Reticulon 3-mediated Chk2/p53 activation suppresses hepatocellular carcinogenesis and is blocked by hepatitis B virus

    المؤلفون: Lei Zhang, Peike Peng, Weicheng Wu, Jianxin Gu, Yuanyuan Ruan, Hao Wu, Ying-Hong Shi, Jia Fan, Shushu Song, Lei Chang

    المصدر: Gut. 70:2159-2171

    مصطلحات موضوعية: Male, 0301 basic medicine, Hepatitis B virus, Programmed cell death, Carcinoma, Hepatocellular, Carcinogenesis, Mice, Nude, Apoptosis, Nerve Tissue Proteins, Biology, Endoplasmic Reticulum, medicine.disease_cause, Malignant transformation, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, medicine, Animals, Humans, Mice, Inbred BALB C, Cell growth, Liver Neoplasms, Gastroenterology, Membrane Proteins, digestive system diseases, Checkpoint Kinase 2, 030104 developmental biology, Reticulon, 030220 oncology & carcinogenesis, Hepatocytes, Cancer research, Tumor Suppressor Protein p53, Signal transduction, Carrier Proteins

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08af016146c39156651989cdaf664092Test
    https://doi.org/10.1136/gutjnl-2020-321386Test


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  3. 3
    Oocyte Elimination Through DNA Damage Signaling from CHK1/CHK2 to p53 and p63

    المؤلفون: John C. Schimenti, Jordana C. Bloom, Vera D. Rinaldi

    المصدر: Genetics

    مصطلحات موضوعية: Male, DNA damage, Cell Cycle Proteins, Investigations, Biology, medicine.disease_cause, Mice, 03 medical and health sciences, 0302 clinical medicine, Prophase, Meiosis, Genetics, Homologous chromosome, medicine, Animals, CHEK1, Checkpoint Kinase 2, 030304 developmental biology, Mice, Knockout, 0303 health sciences, Mutation, Endodeoxyribonucleases, fungi, Synapsis, Cell biology, Chromosome Pairing, enzymes and coenzymes (carbohydrates), 030220 oncology & carcinogenesis, Checkpoint Kinase 1, Oocytes, Trans-Activators, ATPases Associated with Diverse Cellular Activities, Female, Tumor Suppressor Protein p53, biological phenomena, cell phenomena, and immunity, DNA Damage, Signal Transduction

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b34e3673e90e34f5173d0397ef3b8fTest
    https://doi.org/10.1534/genetics.120.303182Test


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  4. 4
    Mutation in histone deacetylase clr6 promotes the survival of S. pombe cds1 null mutant in response to hydroxyurea

    المؤلفون: Lalita Panigrahi, Nafees Ahamad, Shakil Ahmed, Nancy C. Walworth, Saman Khan

    المصدر: Molecular Genetics and Genomics. 295:695-703

    مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, DNA damage, Mutant, Cell Cycle Proteins, Biology, Hydroxamic Acids, medicine.disease_cause, 01 natural sciences, 03 medical and health sciences, Schizosaccharomyces, Genetics, medicine, Hydroxyurea, Enzyme Inhibitors, Phosphorylation, Molecular Biology, CDS1, Mutation, Cell growth, DNA replication, General Medicine, Cell biology, Histone Deacetylase Inhibitors, Replication fork arrest, Checkpoint Kinase 2, 030104 developmental biology, Schizosaccharomyces pombe Proteins, Histone deacetylase, 010606 plant biology & botany

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9847fb8c845717ae4a7de03e776d9ed2Test
    https://doi.org/10.1007/s00438-020-01655-zTest


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  5. 5
    The noncoding function of NELFA mRNA promotes the development of oesophageal squamous cell carcinoma by regulating the Rad17‐RFC2‐5 complex

    المؤلفون: Guangchao Wang, Shichao Guo, Dan Li, Qimin Zhan, Jiancheng Xu, Wei Gong

    المصدر: Molecular Oncology, Vol 14, Iss 3, Pp 611-624 (2020)
    Molecular Oncology

    مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, DNA Repair, Esophageal Neoplasms, Apoptosis, Cell Cycle Proteins, medicine.disease_cause, 0302 clinical medicine, Phosphorylation, RNA, Small Interfering, Replication Protein C, Research Articles, Gene knockdown, BRCA1 Protein, General Medicine, USF2, Prognosis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Up-Regulation, Gene Expression Regulation, Neoplastic, Oncology, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, Molecular Medicine, Female, Esophageal Squamous Cell Carcinoma, Transcriptional Elongation Factors, Research Article, Chromatin Immunoprecipitation, Biology, NELFA mRNA, lcsh:RC254-282, 03 medical and health sciences, Downregulation and upregulation, Cell Line, Tumor, Genetics, medicine, Humans, Aged, Cell Proliferation, Cell Nucleus, Messenger RNA, ESCC, Rad17, In vitro, digestive system diseases, Checkpoint Kinase 2, 030104 developmental biology, RFC2‐5, Checkpoint Kinase 1, Cancer research, Upstream Stimulatory Factors, Carcinogenesis

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6040366c3bb66e06e8aadecd56af20Test
    https://doaj.org/article/deabe6258dc342a8bb0dddfebbe7819aTest


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  6. 6
    HBx natural variants containing Ser-101 instead of Pro-101 evade ubiquitin-dependent proteasomal degradation by activating proteasomal activator 28 gamma expression

    المؤلفون: Kyung Lib Jang, Sungkyung Cha, Hyerin Jeong

    المصدر: Journal of General Virology. 100:1554-1566

    مصطلحات موضوعية: 0301 basic medicine, Hepatitis B virus, Proteasome Endopeptidase Complex, Proline, viruses, 030106 microbiology, Gene Expression, Virus Replication, medicine.disease_cause, Autoantigens, 03 medical and health sciences, Ubiquitin, Downregulation and upregulation, Cell Line, Tumor, Virology, Serine, medicine, Humans, Point Mutation, Viral Regulatory and Accessory Proteins, Replicon, Checkpoint Kinase 2, biology, Activator (genetics), digestive system diseases, Cell biology, HBx, 030104 developmental biology, Proteasome, Host-Pathogen Interactions, Proteolysis, Trans-Activators, biology.protein, Mutant Proteins, Tumor Suppressor Protein p53

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eadc50a2c78e4773e383ee847a93a39Test
    https://doi.org/10.1099/jgv.0.001337Test


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  7. 7
    Association of germline rare pathogenic mutations in guideline-recommended genes with prostate cancer progression: A meta-analysis

    المؤلفون: Qiang Wang, Zhuqing Shi, Jun Wei, Jim Lu, Brian T. Helfand, Lucy Lu, Siqun Lilly Zheng, William Kyle Resurreccion, Kathleen A. Cooney, William B. Isaacs, Wancai Yang, Jianfeng Xu, Valentina Engelmann

    المصدر: The ProstateREFERENCES. 82(1)

    مصطلحات موضوعية: Oncology, Male, medicine.medical_specialty, DNA Repair, Urology, PALB2, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, medicine.disease_cause, Germline, Germline mutation, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Neoplasm Metastasis, CHEK2, Germ-Line Mutation, BRCA2 Protein, Mutation, business.industry, Cancer, Nuclear Proteins, Prostatic Neoplasms, Odds ratio, medicine.disease, Checkpoint Kinase 2, Meta-analysis, business, Fanconi Anemia Complementation Group N Protein

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ad82c40abc15ed1eb10e83b8f2370fTest
    https://pubmed.ncbi.nlm.nih.gov/34674288Test


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  8. 8
    Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication

    المؤلفون: Claire Palles, Sue Cotterill, Sophia Toumazou, Ignacio Soriano, Stephen E. Kearsey, Ian Tomlinson, Sibyl Bertrand, Enrique Vázquez, Zhihan Bo, Nagore De León, Chen-Chun Pai, Ellen Heitzer, Timothy C. Humphrey

    المساهمون: Nitiss, John L.

    المصدر: Soriano, I, Vazquez, E, De Leon, N, Bertrand, S, Heitzer, E, Toumazou, S, Bo, Z, Palles, C, Pai, C, Humphrey, T C, Tomlinson, I, Cotterill, S, Kearsey, S E & Nitiss, J L (ed.) 2021, ' Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication ', PLoS Genetics, vol. 17, no. 7, pp. e1009526 . https://doi.org/10.1371/journal.pgen.1009526Test
    PLoS Genetics, Vol 17, Iss 7, p e1009526 (2021)
    PLoS Genetics

    مصطلحات موضوعية: Cancer Research, Carcinogenesis, DNA polymerase, Yeast and Fungal Models, QH426-470, medicine.disease_cause, Biochemistry, Polymerases, S Phase, Schizosaccharomyces Pombe, chemistry.chemical_compound, 0302 clinical medicine, Neoplasms, Medicine and Health Sciences, Poly-ADP-Ribose Binding Proteins, Genetics (clinical), Polymerase, 0303 health sciences, Mutation, biology, Eukaryota, 3. Good health, Nucleic acids, Experimental Organism Systems, Oncology, 030220 oncology & carcinogenesis, Genome, Fungal, Research Article, DNA Replication, Substitution Mutation, DNA damage, Somatic hypermutation, Research and Analysis Methods, 03 medical and health sciences, Model Organisms, Uterine Cancer, Schizosaccharomyces, DNA-binding proteins, medicine, Genetics, Humans, Molecular Biology, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Colorectal Cancer, Point mutation, DNA Helicases, Organisms, Fungi, DNA replication, Biology and Life Sciences, Proteins, Cancers and Neoplasms, DNA Polymerase II, DNA, Molecular biology, Yeast, Checkpoint Kinase 2, chemistry, Animal Studies, biology.protein, Schizosaccharomyces pombe Proteins, Gynecological Tumors

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5736292b02ba16dfe494bf8ee2923a22Test
    https://openaccess.sgul.ac.uk/id/eprint/113593/1/journal.pgen.1009526.pdfTest


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  9. 9
    Sterigmatocystin, 5-Methoxysterigmatocistin, and Their Combinations Are Cytotoxic and Genotoxic to A549 and Hepg2 Cells and Provoke Phosphorylation of Chk2, but Not Fancd2 Checkpoint Proteins

    المؤلفون: Domagoj Kifer, Maja Šegvić Klarić, Sanja Dabelić, Nevenka Kopjar, Daniela Jakšić

    المصدر: Toxins
    Volume 13
    Issue 7
    Toxins, Vol 13, Iss 464, p 464 (2021)

    مصطلحات موضوعية: 0301 basic medicine, checkpoint proteins, DNA damage, Cell Survival, Health, Toxicology and Mutagenesis, Sterigmatocystin, Toxicology, medicine.disease_cause, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, 5-methoxysterigmatocystin, medicine, Cytotoxic T cell, Humans, Phosphorylation, Cytotoxicity, sterigmatocystin, cytotoxicity, genotoxicity, mycotoxin interactions, A549 cell, Cell growth, Fanconi Anemia Complementation Group D2 Protein, Hep G2 Cells, Molecular biology, Checkpoint Kinase 2, 030104 developmental biology, chemistry, A549 Cells, 030220 oncology & carcinogenesis, Medicine, Comet Assay, Carcinogenesis, Genotoxicity, Mutagens

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f8610f5dc91d890bb3032bccb68075Test


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  10. 10
    Extracellular vesicles activate ATM‐Chk2 signaling pathway through the intercellular transfer of mitochondrial DNA in HBV‐infected human hepatocytes

    المؤلفون: Hiromichi Dansako, Shinya Satoh, Youki Ueda, Nobuyuki Kato

    المصدر: The FASEB Journal. 35

    مصطلحات موضوعية: 0301 basic medicine, Hepatitis B virus, Mitochondrial DNA, Cell, Ataxia Telangiectasia Mutated Proteins, Virus Replication, medicine.disease_cause, DNA, Mitochondrial, Biochemistry, Extracellular vesicles, Extracellular Vesicles, 03 medical and health sciences, 0302 clinical medicine, Genetics, medicine, Humans, Molecular Biology, Pathogen, Chemistry, virus diseases, Hep G2 Cells, Hepatitis B, medicine.disease, digestive system diseases, Cell biology, Checkpoint Kinase 2, 030104 developmental biology, medicine.anatomical_structure, Hepatocellular carcinoma, Hepatocytes, Signal transduction, 030217 neurology & neurosurgery, Intracellular, Biotechnology

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a403a2e8da38a7b1559172af2e37be9Test
    https://doi.org/10.1096/fj.202002678rTest


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