التفاصيل البيبلوغرافية
| العنوان: |
A Longitudinal Study of Immune Cells in Severe COVID-19 Patients. |
| المؤلفون: |
Payen, Didier, Cravat, Maxime, Maadadi, Hadil, Didelot, Carole, Prosic, Lydia, Dupuis, Claire, Losser, Marie-Reine, De Carvalho Bittencourt, Marcelo |
| المصدر: |
Frontiers in Immunology; 10/23/2020, Vol. 11, pN.PAG-N.PAG, 12p |
| مصطلحات موضوعية: |
COVID-19, CLINICAL trial registries, INTENSIVE care units, LONGITUDINAL method, SARS-CoV-2, LYMPHOPENIA |
| مستخلص: |
Little is known about the time-dependent immune responses in severe COVID-19. Data of 15 consecutive patients were sequentially recorded from intensive care unit admission. Lymphocyte subsets and total monocyte and subsets counts were monitored as well as the expression of HLA-DR. For 5 patients, SARS-CoV-2–specific T-cell polyfunctionality was assessed against Spike and Nucleoprotein SARS-CoV-2 peptides. Non-specific inflammation markers were increased in all patients. Median monocyte HLA-DR expression was below the 8,000 AB/C threshold defining acquired immunodepression. A "V" trend curve for lymphopenia, monocyte numbers, and HLA-DR expression was observed with a nadir between days 11 and 14 after symptoms' onset. Intermediate CD14++CD16+ monocytes increased early with a reduction in classic CD14++CD16- monocytes. Polyfunctional SARS-Cov-2–specific CD4 T-cells were present and functional, whereas virus-specific CD8 T-cells were less frequent and not efficient. We report a temporal variation of both innate and adaptive immunity in severe COVID-19 patients, helpful in guiding therapeutic decisions (e.g. anti-inflammatory vs. immunostimulatory ones). We describe a defect in virus-specific CD8 T-cells, a potential biomarker of clinical severity. These combined data also provide helpful knowledge for vaccine design. Clinical Trial Registration: https://clinicaltrials.govTest/ , identifier NCT04386395 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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