دورية أكاديمية
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes
| العنوان: | Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes |
|---|---|
| المؤلفون: | Fachal, L., Aschard, H., Beesley, J., Barnes, D.R., Allen, J., Kar, S., Pooley, K.A., Dennis, J., Michailidou, K., Turman, C., Soucy, P., Lemaçon, A., Lush, M., Tyrer, J.P., Ghoussaini, M., Marjaneh, M.M., Jiang, X., Agata, S., Aittomäki, K., Alonso, M.R., Andrulis, I.L., Anton-Culver, H., Antonenkova, N.N., Arason, A., Arndt, V., Aronson, K.J., Arun, B.K., Auber, B., Auer, P.L., Azzollini, J., Balmaña, J., Barkardottir, R.B., Barrowdale, D., Beeghly-Fadiel, A., Benitez, J., Bermisheva, M., Białkowska, K., Blanco, A.M., Blomqvist, C., Blot, W., Bogdanova, N.V., Bojesen, S.E., Bolla, M.K., Bonanni, B., Borg, A., Bosse, K., Brauch, H., Brenner, H., Briceno, I., Brock, I.W., Brooks-Wilson, A., Brüning, T., Burwinkel, B., Buys, S.S., Cai, Q., Caldés, T., Caligo, M.A., Camp, N.J., Campbell, I., Canzian, F., Carroll, J.S., Carter, B.D., Castelao, J.E., Chiquette, J., Christiansen, H., Chung, W.K., Claes, K.B.M., Clarke, C.L., Mari, V., Berthet, P., Castera, L., Vaur, D., Lallaoui, H., Bignon, Y.-J., Uhrhammer, N., Bonadona, V., Lasset, C., Révillion, F., Vennin, P., Muller, D., Gomes, D.M., Ingster, O., Coupier, I., Pujol, P., Collonge-Rame, M.-A., Mortemousque, I., Bera, O., Rose, M., Baurand, A., Bertolone, G., Faivre, L., Dreyfus, H., Leroux, D., Venat-Bouvet, L., Bézieau, S., Delnatte, C., Chiesa, J., Gilbert-Dussardier, B., Gesta, P., Prieur, F.P., Bronner, M., Sokolowska, J., Coulet, F., Boutry-Kryza, N., Calender, A., Giraud, S., Leone, M., Fert-Ferrer, S., Stoppa-Lyonnet, D., Jiao, Y., Lesueur, F.L., Mebirouk, N., Barouk-Simonet, E., Bubien, V., Longy, M., Sevenet, N., Gladieff, L., Toulas, C., Reimineras, A., Sobol, H., Paillerets, B.B.-D., Cabaret, O., Caron, O., Guillaud-Bataille, M., Rouleau, E., Belotti, M., Buecher, B., Caputo, S., Colas, C., Pauw, A.D., Fourme, E., Gauthier-Villars, M., Golmard, L., Moncoutier, V., Saule, C., Donaldson, A., Murray, A., Brady, A., Brewer, C., Pottinger, C., Miller, C., Gallagher, D., Gregory, H., Cook, J., Eason, J., Adlard, J., Barwell, J., Ong, K.-R., Snape, K., Walker, L., Izatt, L., Side, L., Tischkowitz, M., Rogers, M.T., Porteous, M.E., Ahmed, M., Morrison, P.J., Brennan, P., Eeles, R., Davidson, R., Collée, M., Cornelissen, S., Couch, F.J., Cox, A., Cross, S.S., Cybulski, C., Czene, K., Daly, M.B., de la Hoya, M., Devilee, P., Diez, O., Ding, Y.C., Dite, G.S., Domchek, S.M., Dörk, T., dos-Santos-Silva, I., Droit, A., Dubois, S., Dumont, M., Duran, M., Durcan, L., Dwek, M., Eccles, D.M., Engel, C., Eriksson, M., Evans, D.G., Fasching, P.A., Fletcher, O., Floris, G., Flyger, H., Foretova, L., Foulkes, W.D., Friedman, E., Fritschi, L., Frost, D., Gabrielson, M., Gago-Dominguez, M., Gambino, G., Ganz, P.A., Gapstur, S.M., Garber, J., García-Sáenz, J.A., Gaudet, M.M., Georgoulias, V., Giles, G., Glendon, G., Godwin, A.K., Goldberg, M.S., Goldgar, D.E., González-Neira, A., Tibiletti, M.G., Greene, M.H., Grip, M., Gronwald, J., Grundy, A., Guénel, P., Hahnen, E., Haiman, C.A., Håkansson, N., Hall, P., Hamann, U., Harrington, P.A., Hartikainen, J.M., Hartman, M., He, W., Healey, C.S., Heemskerk-Gerritsen, B.A.M., Heyworth, J., Hillemanns, P., Hogervorst, F.B.L., Hollestelle, A., Hooning, M., Hopper, J., Howell, A., Huang, G., Hulick, P.J., Imyanitov, E.N., Sexton, A., Christian, A., Trainer, A., Spigelman, A., Fellows, A., Shelling, A., Fazio, A.D., Blackburn, A., Crook, A., Meiser, B., Patterson, B., Clarke, C., Saunders, C., Hunt, C., Scott, C., Amor, D., Marsh, D., Edkins, E., Salisbury, E., Haan, E., Neidermayr, E., Macrea, F., Farshid, G., Lindeman, G., Chenevix-Trench, G., Mann, G., Gill, G., Thorne, H., Hickie, I., Winship, I., Flanagan, J., Kollias, J., Visvader, J., Stone, J., Taylor, J., Burke, J., Saunus, J., Forbes, J., Kirk, J., French, J., Tucker, K., Wu, K., Phillips, K., Lipton, L., Andrews, L., Lobb, L., Kentwell, M., Spurdle, M., Cummings, M., Gleeson, M., Harris, M., Jenkins, M., Young, M.A., Delatycki, M., Wallis, M., Burgess, M., Price, M., Brown, M., Southey, M., Bogwitz, M., Field, M., Friedlander, M., Gattas, M., Saleh, M., Hayward, N., Pachter, N., Cohen, P., Duijf, P., James, P., Simpson, P., Fong, P., Butow, P., Williams, R., Kefford, R., Scott, R., Milne, R.L., Balleine, R., Dawson, S.–J., Lok, S., O’Connell, S., Greening, S., Nightingale, S., Edwards, S., Fox, S., McLachlan, S.-A., Lakhani, S., Antill, Y., Aalfs, C., Meijers-Heijboer, H., van Engelen, K., Gille, H., Boere, I., van Deurzen, C., Obdeijn, I.-M., van den Ouweland, A., Seynaeve, C., Siesling, S., Verloop, J., van Asperen, C.J., van Cronenburg, T., Blok, R., de Boer, M., Garcia, E.G., Adank, M., Hogervorst, F., Jenner, D., van Leeuwen, F., Rookus, M., Russell, N., Schmidt, M., van den Belt-Dusebout, S., Kets, C., Mensenkamp, A., de Bock, T., van der Hout, A., Mourits, M., Oosterwijk, J., Ausems, M., Koudijs, M., Baxter, R., Yip, D., Carpenter, J., Davis, A., Pathmanathan, N., Graham, D., Sachchithananthan, M., Isaacs, C., Iwasaki, M., Jager, A., Jakimovska, M., Jakubowska, A., James, P.A., Janavicius, R., Jankowitz, R.C., John, E.M., Johnson, N., Jones, M.E., Jukkola-Vuorinen, A., Jung, A., Kaaks, R., Kang, D., Kapoor, P.M., Karlan, B.Y., Keeman, R., Kerin, M.J., Khusnutdinova, E., Kiiski, J.I., Kitahara, C.M., Ko, Y.-D., Konstantopoulou, I., Kosma, V.-M., Koutros, S., Kubelka-Sabit, K., Kwong, A., Kyriacou, K., Laitman, Y., Lambrechts, D., Lee, E., Leslie, G., Lester, J., Lesueur, F., Lindblom, A., Lo, W.-Y., Long, J., Lophatananon, A., Loud, J.T., Lubiński, J., MacInnis, R.J., Maishman, T., Makalic, E., Mannermaa, A., Manoochehri, M., Manoukian, S., Margolin, S., Martinez, M.E., Matsuo, K., Maurer, T., Mavroudis, D., Mayes, R., McGuffog, L., McLean, C., Meindl, A., Miller, A., Miller, N., Montagna, M., Moreno, F., Muir, K., Mulligan, A.M., Muñoz-Garzon, V.M., Muranen, T.A., Narod, S.A., Nassir, R., Nathanson, K.L., Neuhausen, S.L., Nevanlinna, H., Neven, P., Nielsen, F.C., Nikitina-Zake, L., Norman, A., Offit, K., Olah, E., Olopade, O.I., Olsson, H., Orr, N., Osorio, A., Pankratz, V.S., Papp, J., Park, S.K., Park-Simon, T.-W., Parsons, M.T., Paul, J., Pedersen, I.S., Peissel, B., Peshkin, B., Peterlongo, P., Peto, J., Plaseska-Karanfilska, D., Prajzendanc, K., Prentice, R., Presneau, N., Prokofyeva, D., Pujana, M.A., Pylkäs, K., Radice, P., Ramus, S.J., Rantala, J., Rau-Murthy, R., Rennert, G., Risch, H.A., Robson, M., Romero, A., Rossing, M., Saloustros, E., Sánchez-Herrero, E., Sandler, D.P., Santamariña, M., Sawyer, E.J., Scheuner, M.T., Schmidt, D.F., Schmutzler, R.K., Schneeweiss, A., Schoemaker, M.J., Schöttker, B., Schürmann, P., Scott, R.J., Senter, L., Seynaeve, C.M., Shah, M., Sharma, P., Shen, C.-Y., Shu, X.-O., Singer, C.F., Slavin, T.P., Smichkoska, S., Southey, M.C., Spinelli, J.J., Spurdle, A.B., Sutter, C., Swerdlow, A.J., Tamimi, R.M., Tan, Y.Y., Tapper, W.J., Taylor, J.A., Teixeira, M.R., Tengström, M., Teo, S.H., Terry, M.B., Teulé, A., Thomassen, M., Thull, D.L., Toland, A.E., Tollenaar, R.A.E.M., Tomlinson, I., Torres, D., Torres-Mejía, G., Troester, M.A., Truong, T., Tung, N., Tzardi, M., Ulmer, H.-U., Vachon, C.M., van der Kolk, L.E., van Rensburg, E.J., Vega, A., Viel, A., Vijai, J., Vogel, M.J., Wang, Q., Wappenschmidt, B., Weinberg, C.R., Weitzel, J.N., Wendt, C., Wildiers, H., Winqvist, R., Wolk, A., Wu, A.H., Yannoukakos, D., Zhang, Y., Zheng, W., Hunter, D., Pharoah, P.D.P., Chang-Claude, J., García-Closas, M., Schmidt, M.K., Kristensen, V.N., French, J.D., Edwards, S.L., Antoniou, A.C., Simard, J., Easton, D.F., Kraft, P., Dunning, A.M., Collaborators, GEMO Study, Collaborators, EMBRACE, Investigators, KConFab, Investigators, HEBON, Investigators, ABCTB |
| المساهمون: | Medicum, Kristiina Aittomäki / Principal Investigator, HUSLAB, Department of Medical and Clinical Genetics, University of Helsinki, HUS Comprehensive Cancer Center, Department of Oncology, Clinicum, Staff Services, INDIVIDRUG - Individualized Drug Therapy, HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2020 |
| المجموعة: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: | 1184 Genetics, developmental biology, physiology, GEMO Study Collaborators, COMPREHENSIVE MOLECULAR PORTRAITS, ESTROGEN-RECEPTOR, INTEGRATIVE ANALYSIS, FUNCTIONAL VARIANTS, SUSCEPTIBILITY LOCI, PROTEIN FUNCTION, CHROMATIN, ENHANCER, REVEALS, GENOME-WIDE ASSOCIATION |
| الوصف: | Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions. Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a Bayesian approach (PAINTOR) that combines genetic association, linkage disequilibrium and enriched genomic features to determine variants with high posterior probabilities of being causal. Potentially causal variants were significantly over-represented in active gene regulatory regions and transcription factor binding sites. We applied our INQUSIT pipeline for prioritizing genes as targets of those potentially causal variants, using gene expression (expression quantitative trait loci), chromatin interaction and functional annotations. Known cancer drivers, transcription factors and genes in the developmental, apoptosis, immune system and DNA integrity checkpoint gene ontology pathways were over-represented among the highest-confidence target genes. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Fachal , L , Aschard , H , Beesley , J , Barnes , D R , Allen , J , Kar , S , Pooley , K A , Dennis , J , Michailidou , K , Turman , C , Soucy , P , Lemaçon , A , Lush , M , Tyrer , J P , Ghoussaini , M , Marjaneh , M M , Jiang , X , Agata , S , Aittomäki , K , Alonso , M R , Andrulis , I L , Anton-Culver , H , Antonenkova , N N , Arason , A , Arndt , V , Aronson , K J , Arun , B K , Auber , B , Auer , P L , Azzollini , J , Balmaña , J , Barkardottir , R B , Barrowdale , D , Beeghly-Fadiel , A , Benitez , J , Bermisheva , M , Białkowska , K , Blanco , A M , Blomqvist , C , Blot , W , Bogdanova , N V , Bojesen , S E , Bolla , M K , Bonanni , B , Borg , A , Bosse , K , Brauch , H , Brenner , H , Briceno , I , Brock , I W , Brooks-Wilson , A , Brüning , T , Burwinkel , B , Buys , S S , Cai , Q , Caldés , T , Caligo , M A , Camp , N J , Campbell , I , Canzian , F , Carroll , J S , Carter , B D , Castelao , J E , Chiquette , J , Christiansen , H , Chung , W K , Claes , K B M , Clarke , C L , Mari , V , Berthet , P , Castera , L , Vaur , D , Lallaoui , H , Bignon , Y-J , Uhrhammer , N , Bonadona , V , Lasset , C , Révillion , F , Vennin , P , Muller , D , Gomes , D M , Ingster , O , Coupier , I , Pujol , P , Collonge-Rame , M-A , Mortemousque , I , Bera , O , Rose , M , Baurand , A , Bertolone , G , Faivre , L , Dreyfus , H , Leroux , D , Venat-Bouvet , L , Bézieau , S , Delnatte , C , Chiesa , J , Gilbert-Dussardier , B , Gesta , P , Prieur , F P , Bronner , M , Sokolowska , J , Coulet , F , Boutry-Kryza , N , Calender , A , Giraud , S , Leone , M , Fert-Ferrer , S , Stoppa-Lyonnet , D , Jiao , Y , Lesueur , F L , Mebirouk , N , Barouk-Simonet , E , Bubien , V , Longy , M , Sevenet , N , Gladieff , L , Toulas , C , Reimineras , A , Sobol , H , Paillerets , BB-D , Cabaret , O , Caron , O , Guillaud-Bataille , M , Rouleau , E , Belotti , M , Buecher , B , Caputo , S , Colas , C , Pauw , A D , Fourme , E , Gauthier-Villars , M , Golmard , L , Moncoutier , V , Saule , C , Donaldson , A , Murray , A , Brady , A , Brewer , C , Pottinger , C , Miller , C , Gallagher , D , Gregory , H , Cook , J , Eason , J , Adlard , J , Barwell , J , Ong , K-R , Snape , K , Walker , L , Izatt , L , Side , L , Tischkowitz , M , Rogers , M T , Porteous , M E , Ahmed , M , Morrison , P J , Brennan , P , Eeles , R , Davidson , R , Collée , M , Cornelissen , S , Couch , F J , Cox , A , Cross , S S , Cybulski , C , Czene , K , Daly , M B , de la Hoya , M , Devilee , P , Diez , O , Ding , Y C , Dite , G S , Domchek , S M , Dörk , T , dos-Santos-Silva , I , Droit , A , Dubois , S , Dumont , M , Duran , M , Durcan , L , Dwek , M , Eccles , D M , Engel , C , Eriksson , M , Evans , D G , Fasching , P A , Fletcher , O , Floris , G , Flyger , H , Foretova , L , Foulkes , W D , Friedman , E , Fritschi , L , Frost , D , Gabrielson , M , Gago-Dominguez , M , Gambino , G , Ganz , P A , Gapstur , S M , Garber , J , García-Sáenz , J A , Gaudet , M M , Georgoulias , V , Giles , G , Glendon , G , Godwin , A K , Goldberg , M S , Goldgar , D E , González-Neira , A , Tibiletti , M G , Greene , M H , Grip , M , Gronwald , J , Grundy , A , Guénel , P , Hahnen , E , Haiman , C A , Håkansson , N , Hall , P , Hamann , U , Harrington , P A , Hartikainen , J M , Hartman , M , He , W , Healey , C S , Heemskerk-Gerritsen , B A M , Heyworth , J , Hillemanns , P , Hogervorst , F B L , Hollestelle , A , Hooning , M , Hopper , J , Howell , A , Huang , G , Hulick , P J , Imyanitov , E N , Sexton , A , Christian , A , Trainer , A , Spigelman , A , Fellows , A , Shelling , A , Fazio , A D , Blackburn , A , Crook , A , Meiser , B , Patterson , B , Clarke , C , Saunders , C , Hunt , C , Scott , C , Amor , D , Marsh , D , Edkins , E , Salisbury , E , Haan , E , Neidermayr , E , Macrea , F , Farshid , G , Lindeman , G , Chenevix-Trench , G , Mann , G , Giles , G , Gill , G , Thorne , H , Campbell , I , Hickie , I , Winship , I , Flanagan , J , Kollias , J , Visvader , J , Stone , J , Taylor , J , Burke , J , Saunus , J , Forbes , J , Hopper , J , Beesley , J , Kirk , J , French , J , Tucker , K , Wu , K , Phillips , K , Lipton , L , Andrews , L , Lobb , L , Walker , L , Kentwell , M , Spurdle , M , Cummings , M , Gleeson , M , Harris , M , Jenkins , M , Young , M A , Delatycki , M , Wallis , M , Burgess , M , Price , M , Brown , M , Southey , M , Bogwitz , M , Field , M , Friedlander , M , Gattas , M , Saleh , M , Hayward , N , Pachter , N , Cohen , P , Duijf , P , James , P , Simpson , P , Fong , P , Butow , P , Williams , R , Kefford , R , Scott , R , Milne , R L , Balleine , R , Dawson , S J , Lok , S , O’Connell , S , Greening , S , Nightingale , S , Edwards , S , Fox , S , McLachlan , S-A , Lakhani , S , Antill , Y , Aalfs , C , Meijers-Heijboer , H , van Engelen , K , Gille , H , Boere , I , Collée , M , van Deurzen , C , Hooning , M , Obdeijn , I-M , van den Ouweland , A , Seynaeve , C , Siesling , S , Verloop , J , van Asperen , C J , Devilee , P , van Cronenburg , T , Blok , R , de Boer , M , Garcia , E G , Adank , M , Hogervorst , F , Jenner , D , van Leeuwen , F , Rookus , M , Russell , N , Schmidt , M , van den Belt-Dusebout , S , Kets , C , Mensenkamp , A , de Bock , T , van der Hout , A , Mourits , M , Oosterwijk , J , Ausems , M , Koudijs , M , Clarke , C , Marsh , D , Scott , R , Baxter , R , Yip , D , Carpenter , J , Davis , A , Pathmanathan , N , Simpson , P , Graham , D , Sachchithananthan , M , Isaacs , C , Iwasaki , M , Jager , A , Jakimovska , M , Jakubowska , A , James , P A , Janavicius , R , Jankowitz , R C , John , E M , Johnson , N , Jones , M E , Jukkola-Vuorinen , A , Jung , A , Kaaks , R , Kang , D , Kapoor , P M , Karlan , B Y , Keeman , R , Kerin , M J , Khusnutdinova , E , Kiiski , J I , Kirk , J , Kitahara , C M , Ko , Y-D , Konstantopoulou , I , Kosma , V-M , Koutros , S , Kubelka-Sabit , K , Kwong , A , Kyriacou , K , Laitman , Y , Lambrechts , D , Lee , E , Leslie , G , Lester , J , Lesueur , F , Lindblom , A , Lo , W-Y , Long , J , Lophatananon , A , Loud , J T , Lubiński , J , MacInnis , R J , Maishman , T , Makalic , E , Mannermaa , A , Manoochehri , M , Manoukian , S , Margolin , S , Martinez , M E , Matsuo , K , Maurer , T , Mavroudis , D , Mayes , R , McGuffog , L , McLean , C , Mebirouk , N , Meindl , A , Miller , A , Miller , N , Montagna , M , Moreno , F , Muir , K , Mulligan , A M , Muñoz-Garzon , V M , Muranen , T A , Narod , S A , Nassir , R , Nathanson , K L , Neuhausen , S L , Nevanlinna , H , Neven , P , Nielsen , F C , Nikitina-Zake , L , Norman , A , Offit , K , Olah , E , Olopade , O I , Olsson , H , Orr , N , Osorio , A , Pankratz , V S , Papp , J , Park , S K , Park-Simon , T-W , Parsons , M T , Paul , J , Pedersen , I S , Peissel , B , Peshkin , B , Peterlongo , P , Peto , J , Plaseska-Karanfilska , D , Prajzendanc , K , Prentice , R , Presneau , N , Prokofyeva , D , Pujana , M A , Pylkäs , K , Radice , P , Ramus , S J , Rantala , J , Rau-Murthy , R , Rennert , G , Risch , H A , Robson , M , Romero , A , Rossing , M , Saloustros , E , Sánchez-Herrero , E , Sandler , D P , Santamariña , M , Saunders , C , Sawyer , E J , Scheuner , M T , Schmidt , D F , Schmutzler , R K , Schneeweiss , A , Schoemaker , M J , Schöttker , B , Schürmann , P , Scott , C , Scott , R J , Senter , L , Seynaeve , C M , Shah , M , Sharma , P , Shen , C-Y , Shu , X-O , Singer , C F , Slavin , T P , Smichkoska , S , Southey , M C , Spinelli , J J , Spurdle , A B , Stone , J , Stoppa-Lyonnet , D , Sutter , C , Swerdlow , A J , Tamimi , R M , Tan , Y Y , Tapper , W J , Taylor , J A , Teixeira , M R , Tengström , M , Teo , S H , Terry , M B , Teulé , A , Thomassen , M , Thull , D L , Tischkowitz , M , Toland , A E , Tollenaar , R A E M , Tomlinson , I , Torres , D , Torres-Mejía , G , Troester , M A , Truong , T , Tung , N , Tzardi , M , Ulmer , H-U , Vachon , C M , van Asperen , C J , van der Kolk , L E , van Rensburg , E J , Vega , A , Viel , A , Vijai , J , Vogel , M J , Wang , Q , Wappenschmidt , B , Weinberg , C R , Weitzel , J N , Wendt , C , Wildiers , H , Winqvist , R , Wolk , A , Wu , A H , Yannoukakos , D , Zhang , Y , Zheng , W , Hunter , D , Pharoah , P D P , Chang-Claude , J , García-Closas , M , Schmidt , M K , Milne , R L , Kristensen , V N , French , J D , Edwards , S L , Antoniou , A C , Chenevix-Trench , G , Simard , J , Easton , D F , Kraft , P , Dunning , A M , Collaborators , GEMO S , Collaborators , EMBRACE , Investigators , KC , Investigators , HEBON & Investigators , ABCTB 2020 , ' Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes ' , Nature Genetics , vol. 52 , no. 1 , pp. 56-73 . https://doi.org/10.1038/s41588-019-0537-1Test; Bibtex: Fachal202056; ORCID: /0000-0002-5895-1808/work/70946402; ORCID: /0000-0002-4089-7209/work/83053906; e5e4373c-bc7a-478c-b029-691470af27bd; http://hdl.handle.net/10138/317382Test; 000508163500002 |
| الإتاحة: | http://hdl.handle.net/10138/317382Test |
| حقوق: | openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.685A9B77 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |