المؤلفون: Benaglio, Paola, Zhu, Han, Okino, Mei Lin, Yan, Jian, Elgamal, Ruth, Nariai, Naoki, Beebe, Elisha, Korgaonkar, Katha, Qiu, Yunjiang, Donovan, Margaret K.R., Chiou, Joshua, Wang, Gaowei, Newsome, Jacklyn, Kaur, Jaspreet, Miller, Michael, Preissl, Sebastian, Corban, Sierra, Aylward, Anthony, Taipale, Jussi, Ren, Bing, Frazer, Kelly A., Sander, Maike, Gaulton, Kyle J.

المساهمون: Department of Pathology, Biosciences, Doctoral Programme in Integrative Life Science, Jussi Taipale / Principal Investigator

مصطلحات موضوعية: 3D chromatin interactions, accessible chromatin, beta cell, CRISPR screen, functional genomics, gene expression, high-throughput reporter assay, human genetics, proinflammatory cytokines, type 1 diabetes, General medicine, internal medicine and other clinical medicine, Biomedicine

وصف الملف: application/pdf

العلاقة: The work performed in this study was supported by NIH grants DK122607 and DK120429 to K.J.G. and M.S.; DK112155 to M.S., K.F., K.J.G., and B.R.; and DK105541 to M.S., K.F., and B.R. The work performed in this study was supported by NIH grants DK122607 and DK120429 to K.J.G. and M.S.; DK112155 to M.S. K.F. K.J.G. and B.R.; and DK105541 to M.S. K.F. and B.R. K.J.G. and M.S. conceived of and supervised the study. K.J.G. P.B. H.Z. M.O. and M.S. wrote the manuscript. J.T. and B.R. supervised the design and generation of SNP-SELEX data. K.F. supervised the design of SNP-SELEX and analyses of genomic data. S.P. supervised generation of single-cell data. P.B. performed statistical data analysis of genomic, CRISPR-KO screen, and genetic data; H.Z. performed the CRISPR-KO screen and interpreted the results; M.O. and M.M. performed genomic assays. J.Y. performed the SNP-SELEX assay. P.B. M.O. R.E. E.B. K.K. A.A. J.C. G.W. and J.N. performed bulk and single-cell data analysis. M.O. R.E. J.K. and S.C. performed functional validation experiments. P.B. N.N. Y.Q. A.A. and M.K.D. performed design and analysis of SNP-SELEX data. All authors contributed to and approved of the final version of the manuscript. K.J.G. is a consultant of Genentech and holds stock in Neurocrine Biosciences. B.R. is a consultant of Arima Genomics and a co-founder of Epigenome Technologies. P.B. is an employee of Shoreline Bioscience. N.N. is an employee of Guardant Health. E.B. is an employee and shareholder of Aetion. K.K. is an employee of Cartography Bio. Y.Q. is an employee of Sana Biotechnology. M.D. is an employee and shareholder of Seer. J.C. is an employee and shareholder of Pfizer.; Benaglio , P , Zhu , H , Okino , M L , Yan , J , Elgamal , R , Nariai , N , Beebe , E , Korgaonkar , K , Qiu , Y , Donovan , M K R , Chiou , J , Wang , G , Newsome , J , Kaur , J , Miller , M , Preissl , S , Corban , S , Aylward , A , Taipale , J , Ren , B , Frazer , K A , Sander , M & Gaulton , K J 2022 , ' Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines ' , Cell genomics , vol. 2 , no. 12 , 100214 . https://doi.org/10.1016/j.xgen.2022.100214Test; http://hdl.handle.net/10138/354977Test; c6a62712-0c8b-4078-9442-a6813e9052b5; 85143868567

الإتاحة: http://hdl.handle.net/10138/354977Test

المؤلفون: Melanie Herre, Jessica Cedervall, Nigel Mackman, Anna-Karin Olsson

المصدر: Physiological Reviews. 103:277-312

مصطلحات موضوعية: Neutrophils, Physiology, Neoplasms, Physiology (medical), Humans, Thrombosis, General Medicine, Extracellular Traps, Molecular Biology, Chromatin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619fdaf8ff2f95c42d7cf49ff22f267eTest
https://doi.org/10.1152/physrev.00062.2021Test

المؤلفون: Gerardo Zapata, Keqin Yan, David J Picketts

المصدر: Hum Mol Genet

مصطلحات موضوعية: Mice, Knockout, Sucrose, Facies, Antigens, Nuclear, Nerve Tissue Proteins, Syndrome, General Medicine, Chromatin Assembly and Disassembly, Actins, Chromatin, Nucleosomes, Mice, Neurodevelopmental Disorders, Basic Helix-Loop-Helix Transcription Factors, Genetics, Animals, Original Article, Amino Acids, Molecular Biology, Genetics (clinical), Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95039255004c90f41c0c9e60a963d8d4Test
https://doi.org/10.1093/hmg/ddac119Test

المؤلفون: Thomas Roulé, Aurelie Christ, Nosheen Hussain, Ying Huang, Caroline Hartmann, Moussa Benhamed, Jose Gutierrez-Marcos, Federico Ariel, Martin Crespi, Thomas Blein

المساهمون: Institut des Sciences des Plantes de Paris-Saclay (IPS2 (UMR_9213 / UMR_1403)), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Warwick [Coventry], Instituto de Agrobiotecnología del Litoral [Santa Fe] (IAL), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Universidad Nacional del Litoral [Santa Fe] (UNL), BBSRC grant (BB/L016966/1)CNRS (Laboratoire International Associé NOCOSYM)Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation' (MESRI)

المصدر: Molecular Plant
Molecular Plant, 2022, 15 (5), pp.1-58. ⟨10.1016/j.molp.2022.02.007⟩

مصطلحات موضوعية: marneral, epigenetics, Arabidopsis, seed germination, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, General Medicine, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, Chromatin, Triterpenes, Epigenesis, Genetic, lncRNA, chromatin conformation, LHP1, ABA, Chromobox Protein Homolog 5, RNA, Long Noncoding, enhancer, cluster, Abscisic Acid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d42103d79c019b15bd1bb304d561eeTest
https://doi.org/10.1016/j.molp.2022.02.007Test

المؤلفون: Logie, Emilie, Van Puyvelde, Bart, Cuypers, Bart, Schepers, Anne, Berghmans, Herald, Verdonck, Jelle, Laukens, Kris, Godderis, Lode, Dhaenens, Maarten, Deforce, Dieter, Vanden Berghe, Wim

المصدر: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ; ISSN: 1422-0067

مصطلحات موضوعية: Biology and Life Sciences, Chemistry, Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis, ferroptosis, multiple myeloma, DNA methylationiron, histone post-translational modifications, epigenome, CHROMATIN MODIFIERS, EXPRESSION, H2A.Z, METABOLISM, INHIBITION, ACCUMULATION, ACTIVATION, RESISTANCE, MECHANISM, HALLMARKS

وصف الملف: application/pdf

العلاقة: https://biblio.ugent.be/publication/8726700Test; http://hdl.handle.net/1854/LU-8726700Test; http://dx.doi.org/10.3390/ijms222212234Test; https://biblio.ugent.be/publication/8726700/file/8726701Test

الإتاحة: https://doi.org/10.3390/ijms222212234Test
https://biblio.ugent.be/publication/8726700Test
http://hdl.handle.net/1854/LU-8726700Test
https://biblio.ugent.be/publication/8726700/file/8726701Test

المؤلفون: Seyfferth, Carolin, Renema, Jim, Wendrich, Jos, Eekhout, Thomas, Seurinck, Ruth, Vandamme, Niels, Blob, Bernhard, Saeys, Yvan, Helariutta, Yrjo, Birnbaum, Kenneth D., De Rybel, Bert

المصدر: ANNUAL REVIEW OF PLANT BIOLOGY ; ISSN: 1543-5008 ; ISSN: 1545-2123

مصطلحات موضوعية: Biology and Life Sciences, Plant Science, Cell Biology, Physiology, Molecular Biology, General Medicine, scRNA-seq, plant transcriptomics, protoplast, cell atlas, cell trajectory, GENE-EXPRESSION, IN-SITU, RNA, GENOME, MAP, CHROMATIN, SEQUENCE, DIFFERENTIATION, TECHNOLOGIES, LANDSCAPE

وصف الملف: application/pdf

العلاقة: https://biblio.ugent.be/publication/8701588Test; http://hdl.handle.net/1854/LU-8701588Test; http://dx.doi.org/10.1146/annurev-arplant-081720-010120Test; https://biblio.ugent.be/publication/8701588/file/8701590Test

الإتاحة: https://doi.org/10.1146/annurev-arplant-081720-010120Test
https://biblio.ugent.be/publication/8701588Test
http://hdl.handle.net/1854/LU-8701588Test
https://biblio.ugent.be/publication/8701588/file/8701590Test

المؤلفون: Yingyao Shi, Wei Zeng, Minhui Xu, Hua Li, Fanlin Zhang, Zulong Chen, Gatera Anicet, Shiji Huang, Yuheng Huang, Xiyu Wang, Junhao Li, Xinyu Zhang, Yuxing Zheng, Shamsur Rehman

المصدر: Current Issues in Molecular Biology; Volume 44; Issue 12; Pages: 6404-6427

مصطلحات موضوعية: Microbiology (medical), glutamate receptor-like genes, evolution, expression variation, chromatin accessibility, gcHap, population variation, General Medicine, Molecular Biology, Microbiology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df10dc029ec2c15cd6ccc7342cb7eddfTest
https://doi.org/10.3390/cimb44120437Test

المؤلفون: Yuna Youn, Jae Hyeong Kim, Jin-Hyeok Hwang

المصدر: Molecules and Cells. 45:792-805

مصطلحات موضوعية: Chromosomal Instability, Humans, Nuclear Proteins, Cell Cycle Proteins, DNA, Cell Biology, General Medicine, Molecular Biology, Chromatin, Chromosomes

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a38eab8461daf28371120a18712600Test
https://doi.org/10.14348/molcells.2022.0048Test

المؤلفون: JACQUELINE SOTO-SÁNCHEZ

المصدر: Mini-Reviews in Medicinal Chemistry. 22:2661-2677

مصطلحات موضوعية: Flavonoids, Pharmacology, Antiparasitic Agents, Arginase, Drug Discovery, Antiprotozoal Agents, Humans, Polyphenols, General Medicine, Leishmaniasis, Chromatin, Lignans

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9935f54dda9d5b26dd7a47d45a0a275bTest
https://doi.org/10.2174/1389557522666220404090429Test

المؤلفون: Anantharam Devaraj, Manvendra Singh, Suneel A Narayanavari, Guo Yong, Jiaxuan Chen, Jichang Wang, Mareike Becker, Oliver Walisko, Andrea Schorn, Zoltán Cseresznyés, Tamás Raskó, Kathrin Radscheit, Matthias Selbach, Zoltán Ivics, Zsuzsanna Izsvák

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7283

مصطلحات موضوعية: Inorganic Chemistry, Cancer Research, Cardiovascular and Metabolic Diseases, Sleeping Beauty, transposon, HMGXB4, transcriptional activator, H3K4me3, NuRF, MLL complex, chromatin remodeling, nucleolus, BAP18/C17orf49, SUMOylation, germline, germinal stem cell, Wnt signaling, chromatin domain boundary, Organic Chemistry, General Medicine, Physical and Theoretical Chemistry, Function and Dysfunction of the Nervous System, Molecular Biology, Spectroscopy, Catalysis, Computer Science Applications

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbe56c23238d502e41a5fc80ae073e0Test
http://edoc.mdc-berlin.de/23252/2/23252suppl.zipTest