Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia
| العنوان: | Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia |
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| المؤلفون: | Zania, Diabasana, Jeanne-Marie, Perotin, Randa, Belgacemi, Julien, Ancel, Pauline, Mulette, Claire, Launois, Gonzague, Delepine, Xavier, Dubernard, Jean-Claude, Mérol, Christophe, Ruaux, Philippe, Gosset, Uwe, Maskos, Myriam, Polette, Gaëtan, Deslée, Valérian, Dormoy |
| المساهمون: | Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 (P3CELL), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Reims (CHU Reims), Clinique mutualiste La Sagesse, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Neurobiologie intégrative des Systèmes cholinergiques / Integrative Neurobiology of Cholinergic Systems (NISC), Institut Pasteur [Paris] (IP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), This work was supported by Funding from University of Reims Champagne-Ardenne (Université de Reims Champagne-Ardenne, URCA), the French National Institute of Health and Medical Research (Institut National de la Santé et de la Recherche Médicale, Inserm) and a grant from the Research Institute in Public Health (IReSP) in association with the National Institute of Cancer (INCa). It was carried out in the framework of the Federative Research Structure CAP-Santé and benefited from the Project Research and Innovation in Inflammatory Respiratory Diseases (RINNOPARI)., Sorbonne Université (SU)-Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), dormoy, valerian |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, 2021, 22 (13), pp.6657. ⟨10.3390/ijms22136657⟩ International Journal of Molecular Sciences, Vol 22, Iss 6657, p 6657 (2021) International Journal of Molecular Sciences, MDPI, 2021, 22 (13), pp.6657. ⟨10.3390/ijms22136657⟩ |
| بيانات النشر: | HAL CCSD, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Lung Diseases, rs16969968, QH301-705.5, Nerve Tissue Proteins, Respiratory Mucosa, Receptors, Nicotinic, Polymorphism, Single Nucleotide, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], mental disorders, Humans, Genetic Predisposition to Disease, remodelling, Biology (General), QD1-999, Cells, Cultured, Chromosomes, Human, Pair 15, Gene Expression Profiling, Communication, Cell Differentiation, Tobacco Use Disorder, differentiation, Chemistry, Gene Expression Regulation, inflammation, Multigene Family, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, airway epithelial cells |
| الوصف: | International audience; The gene cluster region, CHRNA3/CHRNA5/CHRNB4, encoding for nicotinic acetylcholine receptor (nAChR) subunits, contains several genetic variants linked to nicotine addiction and brain disorders. The CHRNA5 single-nucleotide polymorphism (SNP) rs16969968 is strongly associated with nicotine dependence and lung diseases. Using immunostaining studies on tissue sections and air-liquid interface airway epithelial cell cultures, in situ hybridisation, transcriptomic and cytokines detection, we analysed rs16969968 contribution to respiratory airway epithelial remodelling and modulation of inflammation. We provide cellular and molecular analyses which support the genetic association of this polymorphism with impaired ciliogenesis and the altered production of inflammatory mediators. This suggests its role in lung disease development. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1661-6596 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::973358caadb8ce1b6a49c34ab1810498Test https://hal.univ-reims.fr/hal-03278065Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....973358caadb8ce1b6a49c34ab1810498 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16616596 14220067 |
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