المؤلفون: Benaglio, Paola, Zhu, Han, Okino, Mei Lin, Yan, Jian, Elgamal, Ruth, Nariai, Naoki, Beebe, Elisha, Korgaonkar, Katha, Qiu, Yunjiang, Donovan, Margaret K.R., Chiou, Joshua, Wang, Gaowei, Newsome, Jacklyn, Kaur, Jaspreet, Miller, Michael, Preissl, Sebastian, Corban, Sierra, Aylward, Anthony, Taipale, Jussi, Ren, Bing, Frazer, Kelly A., Sander, Maike, Gaulton, Kyle J.

المساهمون: Department of Pathology, Biosciences, Doctoral Programme in Integrative Life Science, Jussi Taipale / Principal Investigator

مصطلحات موضوعية: 3D chromatin interactions, accessible chromatin, beta cell, CRISPR screen, functional genomics, gene expression, high-throughput reporter assay, human genetics, proinflammatory cytokines, type 1 diabetes, General medicine, internal medicine and other clinical medicine, Biomedicine

وصف الملف: application/pdf

العلاقة: The work performed in this study was supported by NIH grants DK122607 and DK120429 to K.J.G. and M.S.; DK112155 to M.S., K.F., K.J.G., and B.R.; and DK105541 to M.S., K.F., and B.R. The work performed in this study was supported by NIH grants DK122607 and DK120429 to K.J.G. and M.S.; DK112155 to M.S. K.F. K.J.G. and B.R.; and DK105541 to M.S. K.F. and B.R. K.J.G. and M.S. conceived of and supervised the study. K.J.G. P.B. H.Z. M.O. and M.S. wrote the manuscript. J.T. and B.R. supervised the design and generation of SNP-SELEX data. K.F. supervised the design of SNP-SELEX and analyses of genomic data. S.P. supervised generation of single-cell data. P.B. performed statistical data analysis of genomic, CRISPR-KO screen, and genetic data; H.Z. performed the CRISPR-KO screen and interpreted the results; M.O. and M.M. performed genomic assays. J.Y. performed the SNP-SELEX assay. P.B. M.O. R.E. E.B. K.K. A.A. J.C. G.W. and J.N. performed bulk and single-cell data analysis. M.O. R.E. J.K. and S.C. performed functional validation experiments. P.B. N.N. Y.Q. A.A. and M.K.D. performed design and analysis of SNP-SELEX data. All authors contributed to and approved of the final version of the manuscript. K.J.G. is a consultant of Genentech and holds stock in Neurocrine Biosciences. B.R. is a consultant of Arima Genomics and a co-founder of Epigenome Technologies. P.B. is an employee of Shoreline Bioscience. N.N. is an employee of Guardant Health. E.B. is an employee and shareholder of Aetion. K.K. is an employee of Cartography Bio. Y.Q. is an employee of Sana Biotechnology. M.D. is an employee and shareholder of Seer. J.C. is an employee and shareholder of Pfizer.; Benaglio , P , Zhu , H , Okino , M L , Yan , J , Elgamal , R , Nariai , N , Beebe , E , Korgaonkar , K , Qiu , Y , Donovan , M K R , Chiou , J , Wang , G , Newsome , J , Kaur , J , Miller , M , Preissl , S , Corban , S , Aylward , A , Taipale , J , Ren , B , Frazer , K A , Sander , M & Gaulton , K J 2022 , ' Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines ' , Cell genomics , vol. 2 , no. 12 , 100214 . https://doi.org/10.1016/j.xgen.2022.100214Test; http://hdl.handle.net/10138/354977Test; c6a62712-0c8b-4078-9442-a6813e9052b5; 85143868567

الإتاحة: http://hdl.handle.net/10138/354977Test

المؤلفون: Shuyue, Luo, Xiangjun, Dong, Shipeng, Guo, Qunxian, Wang, Xi, Dai, Yanshuang, Jiang, Weiyi, Zhu, Weihui, Zhou, Weihong, Song

المصدر: Journal of Alzheimer's Disease. 88:1469-1485

مصطلحات موضوعية: Chromatin Immunoprecipitation, General Neuroscience, Gene Expression, Electrophoretic Mobility Shift Assay, General Medicine, DNA-Binding Proteins, Mice, Psychiatry and Mental health, Clinical Psychology, Gene Expression Regulation, Animals, Humans, Geriatrics and Gerontology, Promoter Regions, Genetic, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fce2e95c20132d9da14ca0f86f86825Test
https://doi.org/10.3233/jad-220321Test

المؤلفون: Adam J. Lawther, Haoyu Wu, Luke Isbel, Lucia Daxinger, Harald Oey, Matthew W. Hale, Lexie Prokopuk, Emma Whitelaw, Alex Spurling

المصدر: eLife, 5
eLife
eLife, Vol 5 (2016)

مصطلحات موضوعية: 0301 basic medicine, CCCTC-Binding Factor, Chromatin Immunoprecipitation, Mouse, QH301-705.5, Science, Mutant, Kruppel-Like Transcription Factors, Protocadherin, Nerve Tissue Proteins, Biology, General Biochemistry, Genetics and Molecular Biology, Gene Knockout Techniques, Mice, 03 medical and health sciences, Cerebellum, Gene expression, Animals, momme, Epigenetics, Biology (General), Promoter Regions, Genetic, Transcription factor, Uncategorized, Mice, Knockout, Regulation of gene expression, Binding Sites, widely interspaced zinc finger motifs, Behavior, Animal, epigenetics, General Immunology and Microbiology, General Neuroscience, Promoter, Sequence Analysis, DNA, General Medicine, Molecular biology, 030104 developmental biology, Gene Expression Regulation, Genes and Chromosomes, Medicine, Chromatin immunoprecipitation, Protein Binding, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95403115a3669ca0b6197e7d6185c22Test

المؤلفون: Toshikazu Kakizaki, Hideki Uosaki, Azumi Noguchi, Kinichi Nakashima, Yuchio Yanagawa, Hirokazu Arakawa, Katsuhide Igarashi, Yuichi Uosaki, Takumi Takizawa, Ruri Kaneda, Kenji Ito, Hideyuki Nakashima, Maky Ideta-Otsuka

المصدر: Neuroscience Research. 173:22-33

مصطلحات موضوعية: 0301 basic medicine, Neurogenesis, Locus (genetics), Biology, gene positioning, Mice, 03 medical and health sciences, 0302 clinical medicine, Transcription (biology), Gene expression, medicine, Transcriptional regulation, Animals, Humans, Gene, Cell Nucleus, Neurons, Genetics, Lamin Type B, maturation, General Neuroscience, General Medicine, neuron, Chromatin, Cell biology, 030104 developmental biology, medicine.anatomical_structure, gene expression, chromatin, Nucleus, 030217 neurology & neurosurgery, Lamin, nuclear lamina

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f364ceff0cef3a01a079061f6b10f54Test
http://hdl.handle.net/2324/4798375Test

المؤلفون: Kwang Won Jeong

المصدر: Current Issues in Molecular Biology
Volume 43
Issue 3
Pages 115-1631
Current Issues in Molecular Biology, Vol 43, Iss 115, Pp 1623-1631 (2021)

مصطلحات موضوعية: Transcriptional Activation, Microbiology (medical), Chromatin Immunoprecipitation, Transcription, Genetic, QH301-705.5, RNA polymerase II, Retinal Pigment Epithelium, Microbiology, Cell Line, BRG1, Transcription (biology), Coactivator, Gene expression, Basic Helix-Loop-Helix Transcription Factors, Cytochrome P-450 CYP1A1, Humans, Biology (General), FLII, Molecular Biology, biology, aryl hydrocarbon receptor, Chemistry, Gene Expression Profiling, Microfilament Proteins, Epithelial Cells, Histone-Lysine N-Methyltransferase, retinal pigment epithelial cell, General Medicine, respiratory system, Aryl hydrocarbon receptor, Chromatin, Cell biology, Gene Expression Regulation, Receptors, Aryl Hydrocarbon, Nuclear receptor, Histone methyltransferase, Trans-Activators, biology.protein, MLL1, transcription, Myeloid-Lymphoid Leukemia Protein, Protein Binding

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485e9ade5a3c554fe638977b8c5b596eTest
https://doi.org/10.3390/cimb43030115Test

المؤلفون: Carol F. Webb, Brittany Chapman, Patrick M. Gaffney, Malini Shankar, Kira Rose, Joshua Garton

المصدر: Immunohorizons

مصطلحات موضوعية: Fetal Globulins, Immunology, KLF1, Biology, Article, Transcriptome, Gene expression, Humans, Immunology and Allergy, Erythropoiesis, RNA-Seq, Gene knockdown, GATA2, Gene Expression Regulation, Developmental, GATA1, General Medicine, Chromatin, Cell biology, DNA-Binding Proteins, Gene Knockdown Techniques, Chromatin Immunoprecipitation Sequencing, CRISPR-Cas Systems, K562 Cells, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0f940964d87e7165ece5e5183d2283Test
https://doi.org/10.4049/immunohorizons.2100083Test

المؤلفون: Etienne Almayrac, Fabiola García Fernández, Ànnia Carré Simon, Renaud Batrin, Yasmine Khalil, Michel Boissac, Emmanuelle Fabre

المساهمون: Génomes, biologie cellulaire et thérapeutiques (GenCellDi (U944 / UMR7212)), Collège de France (CdF (institution))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), FABRE, Emmanuelle

المصدر: eLife
eLife, 2022, 11, ⟨10.7554/eLife.78015⟩

مصطلحات موضوعية: double-strand break, chromosomes, General Immunology and Microbiology, [SDV]Life Sciences [q-bio], General Neuroscience, S. cerevisiae, homologous recombination, DNA, General Medicine, yeast, Chromatin, General Biochemistry, Genetics and Molecular Biology, chromosome organization, [SDV] Life Sciences [q-bio], gene expression, genomics, DNA Breaks, Double-Stranded, genetics, chromatin dynamics, γ-H2A(X)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdba3b563bc8457c4721620794e20aa4Test
https://doi.org/10.7554/elife.78015Test

المؤلفون: Shicong Wang, Jieqiang He, Mengting Deng, Caixia Wang, Ruifeng Wang, Jinjiao Yan, Minrong Luo, Fengwang Ma, Qingmei Guan, Jidi Xu

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11191

مصطلحات موضوعية: Organic Chemistry, Gene Expression, High-Throughput Nucleotide Sequencing, Transposases, General Medicine, DNA-Directed RNA Polymerases, Catalysis, Chromatin, Computer Science Applications, Droughts, Inorganic Chemistry, apple, drought, chromatin accessibility, gene expression, ATAC-seq, RNA-seq, Malus, Chromatin Immunoprecipitation Sequencing, RNA-Seq, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d252fe9eaba2627d1e8865e6d23b474Test
https://pubmed.ncbi.nlm.nih.gov/36232500Test

المؤلفون: Alexandra K. Isagulieva, Dmitry N. Kaluzhny, Artemy D. Beniaminov, Nataliya V. Soshnikova, Alexander A. Shtil

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 8871

مصطلحات موضوعية: Binding Sites, Transcription, Genetic, Organic Chemistry, General Medicine, DNA, Catalysis, Chromatin, Computer Science Applications, Inorganic Chemistry, aureolic-acid-derived antibiotics, olivomycin A, RNA polymerase II, chromatin, transcription, gene expression, RNA Polymerase II, Physical and Theoretical Chemistry, Promoter Regions, Genetic, Molecular Biology, Spectroscopy, Olivomycins, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da14938b28e71d404f8d89eb4e0edc73Test

المؤلفون: Sébastien Calvet, Séphora Sallis, Nehmé Saksouk, Cosette Rebouissou, Catherine Teyssier, Annick Lesne, Florence Cammas, Thierry Forné

المساهمون: FORNE, Thierry, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Laboratoire de Physique Théorique de la Matière Condensée (LPTMC), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), AFM-Téléthon N°21024, Institut de génétique humaine (IGH), cammas, florence

المصدر: Cells; Volume 11; Issue 15; Pages: 2392
Cells
Cells, 2022, 11 (15), pp.2392. ⟨10.3390/cells11152392⟩

مصطلحات موضوعية: Mammals, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, HP1, [SDV]Life Sciences [q-bio], Gene Expression, General Medicine, Trim24, Chromatin, endogenous retroviruses, [SDV] Life Sciences [q-bio], Chromobox Protein Homolog 5, chromatin organization, Heterochromatin, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Animals, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e40af38b379fe548b3eb2098d358c38Test