The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients
| العنوان: | The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients |
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| المؤلفون: | Saber Cherif, Lynda, Diabasana, Zania, Perotin, Jeanne-Marie, Ancel, Julien, Petit, Laure, Devilliers, Maëva, Bonnomet, Arnaud, Lalun, Nathalie, Delepine, Gonzague, Maskos, Uwe, Gosset, Philippe, Polette, Myriam, Muggeo, Anaëlle, Guillard, Thomas, Deslée, Gaëtan, Dormoy, Valérian |
| المساهمون: | Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 (P3CELL), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Reims (CHU Reims), Plateforme en Imagerie Cellulaire et Tissulaire (PICT), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA), Neurobiologie intégrative des Systèmes cholinergiques / Integrative Neurobiology of Cholinergic Systems (NISC), Institut Pasteur [Paris] (IP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), This research was funded by the University of Reims Champagne-Ardenne (URCA), the French National Institute of Health and Medical Research (Inserm) and a grant from the Research Institute in Public Health (IReSP) in association with the National Institute of Cancer (INCa) (IRESP-19-PINACRAECOPD)., Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV), DECRAUX, Sylvie |
| المصدر: | Cells Cells, 2022, 11 (19), pp.2937. ⟨10.3390/cells11192937⟩ |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | nicotinic receptors, rs16969968, [SDV]Life Sciences [q-bio], Receptors, Nicotinic, [SDV] Life Sciences [q-bio], Pulmonary Disease, Chronic Obstructive, epithelial remodeling, inflammation, Formaldehyde, COPD, Airway Remodeling, Humans, Inflammation Mediators, airways, Genome-Wide Association Study |
| الوصف: | International audience; Genome-wide association studies unveiled the associations between the single nucleotide polymorphism rs16969968 of CHRNA5, encoding the nicotinic acetylcholine receptor alpha5 subunit (α5SNP), and nicotine addiction, cancer, and COPD independently. Here, we investigated α5SNP-induced epithelial remodeling and inflammatory response in human COPD airways. We included 26 α5SNP COPD patients and 18 wild-type α5 COPD patients in a multi-modal study. A comparative histologic analysis was performed on formalin-fixed paraffin-embedded lung tissues. Isolated airway epithelial cells from bronchial brushings were cultivated in the air-liquid interface. Broncho-alveolar fluids were collected to detect inflammatory mediators. Ciliogenesis was altered in α5SNP COPD bronchial and bronchiolar epithelia. Goblet cell hyperplasia was exacerbated in α5SNP small airways. The broncho-alveolar fluids of α5SNP COPD patients exhibited an increase in inflammatory mediators. The involvement of the rs16969968 polymorphism in airway epithelial remodeling and related inflammatory response in COPD prompts the development of innovative personalized diagnostic and therapeutic strategies. |
| وصف الملف: | application/pdf |
| تدمد: | 2073-4409 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2d9809676f7fc37abdcd5e81f698951eTest https://pubmed.ncbi.nlm.nih.gov/36230899Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....2d9809676f7fc37abdcd5e81f698951e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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