دورية أكاديمية
Molecular epidemiology and evolution of influenza viruses circulating within European swine between 2009 and 2013
| العنوان: | Molecular epidemiology and evolution of influenza viruses circulating within European swine between 2009 and 2013 |
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| المؤلفون: | Watson, SJ, Langat, P, Reid, SM, Lam, TT-Y, Cotten, M, Kelly, M, Van Reeth, K, Qiu, Y, Simon, G, Bonin, E, Foni, E, Chiapponi, C, Larsen, L, Hjulsager, C, Markowska-Daniel, I, Urbaniak, K, Duerrwald, R, Schlegel, M, Huovilainen, A, Davidson, I, Dan, A, Loeffen, W, Edwards, S, Bublot, M, Vila, T, Maldonado, J, Valls, L, Brown, IH, Pybus, OG, Kellam, P |
| المصدر: | 9931 ; 9920 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2015 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Virology, A VIRUSES, GENETIC REASSORTMENT, UNITED-STATES, H1N1, TRANSMISSION, INFERENCE, H3N2, DYNAMICS, PIGS, EMERGENCE, Animals, Epidemiological Monitoring, Europe, Evolution, Molecular, Genotype, Humans, Influenza A Virus, H1N1 Subtype, H1N2 Subtype, H3N2 Subtype, Influenza, Human, Molecular Epidemiology, Orthomyxoviridae Infections, Phylogeny, Reassortant Viruses |
| الوصف: | The emergence in humans of the A(H1N1)pdm09 influenza virus, a complex reassortant virus of swine origin, highlighted the importance of worldwide influenza virus surveillance in swine. To date, large-scale surveillance studies have been reported for southern China and North America, but such data have not yet been described for Europe. We report the first large-scale genomic characterization of 290 swine influenza viruses collected from 14 European countries between 2009 and 2013. A total of 23 distinct genotypes were identified, with the 7 most common comprising 82% of the incidence. Contrasting epidemiological dynamics were observed for two of these genotypes, H1huN2 and H3N2, with the former showing multiple long-lived geographically isolated lineages, while the latter had short-lived geographically diffuse lineages. At least 32 human-swine transmission events have resulted in A(H1N1)pdm09 becoming established at a mean frequency of 8% across European countries. Notably, swine in the United Kingdom have largely had a replacement of the endemic Eurasian avian virus-like (“avian-like”) genotypes with A(H1N1)pdm09-derived genotypes. The high number of reassortant genotypes observed in European swine, combined with the identification of a genotype similar to the A(H3N2)v genotype in North America, underlines the importance of continued swine surveillance in Europe for the purposes of maintaining public health. This report further reveals that the emergences and drivers of virus evolution in swine differ at the global level. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1098-5514 |
| العلاقة: | Journal of Virology; http://hdl.handle.net/10044/1/69578Test |
| DOI: | 10.1128/JVI.00840-15 |
| الإتاحة: | https://doi.org/10.1128/JVI.00840-15Test http://hdl.handle.net/10044/1/69578Test |
| حقوق: | © 2015 Watson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (https://creativecommons.org/licenses/by/3.0Test/). |
| رقم الانضمام: | edsbas.AC892042 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10985514 |
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| DOI: | 10.1128/JVI.00840-15 |