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phip - a novel candidate breast cancer susceptibility locus on 6q14.1

التفاصيل البيبلوغرافية
العنوان: phip - a novel candidate breast cancer susceptibility locus on 6q14.1
المؤلفون: Jiao, Xiang, Aravidis, Christos, Marikkannu, Rajeshwari, Rantala, Johanna, Picelli, Simone, Adamovic, Tatjana, Liu, Tao, Maguire, Paula, Kremeyer, Barbara, Luo, Liping, von Holst, Susanna, Kontham, Vinaykumar, Thutkawkorapin, Jessada, Margolin, Sara, Du, Quan, Lundin, Johanna, Michailidou, Kyriaki, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Lush, Michael, Ambrosone, Christine B., Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia N., Arndt, Volker, Beckmann, Matthias W., Blomqvist, Carl, Blot, William, Boeckx, Bram, Bojesen, Stig E., Bonanni, Bernardo, Brand, Judith S., Brauch, Hiltrud, Brenner, Hermann, Broeks, Annegien, Brüning, Thomas, Burwinkel, Barbara, Cai, Qiuyin, Chang-Claude, Jenny, Collaborators, NBCS, Couch, Fergus J., Cox, Angela, Cross, Simon S., Deming-Halverson, Sandra L., Devilee, Peter, dos-Santos-Silva, Isabel, Dörk, Thilo, Eriksson, Mikael, Fasching, Peter A., Figueroa, Jonine, Flesch-Janys, Dieter, Flyger, Henrik, Gabrielson, Marike, García-Closas, Montserrat, Giles, Graham G., González-Neira, Anna, Guénel, Pascal, Guo, Qi, Gündert, Melanie, Haiman, Christopher A., Hallberg, Emily, Hamann, Ute, Harrington, Patricia, Hooning, Maartje J., Hopper, John L., Huang, Guanmengqian, Jakubowska, Anna, Jones, Michael E., Kerin, Michael J., Kosma, Veli-Matti, Kristensen, Vessela N., Lambrechts, Diether, Marchand, Loic Le, Lubinski, Jan, Mannermaa, Arto, Martens, John W.M., Meindl, Alfons, Milne, Roger L., Mulligan, Anna Marie, Neuhausen, Susan L., Nevanlinna, Heli, Peto, Julian, Pylkas, Katri, Radice, Paolo, Rhenius, Valerie, Sawyer, Elinor J., Schmidt, Marjanka K., Schmutzler, Rita K., Seynaeve, Caroline, Shah, Mitul, Simard, Jacques, Southey, Melissa C., Swerdlow, Anthony J., Truong, Therese, Wendt, Camilla, Winqvist, Robert, Zheng, Wei, Investigators, kConFab/AOCS, Benitez, Javier, Dunning, Alison M., Pharoah, Paul D.P., Easton, Douglas F., Czene, Kamila, Hall, Per, Lindblom, Annika
بيانات النشر: Impact Journals, LLC
سنة النشر: 2017
المجموعة: National University of Ireland (NUI), Galway: ARAN
مصطلحات موضوعية: familial breast cancer, linkage analysis, risk haplotype, sequencing, DNA-sequencing data, wide linkage scan, genome, mutations, families, gene, association, expression, localization, discovery
الوصف: Most non-BRCA1/2 breast cancer families have no identified genetic cause. We used linkage and haplotype analyses in familial and sporadic breast cancer cases to identify a susceptibility locus on chromosome 6q. Two independent genome-wide linkage analysis studies suggested a 3 Mb locus on chromosome 6q and two unrelated Swedish families with a LOD > 2 together seemed to share a haplotype in 6q14.1. We hypothesized that this region harbored a rare high-risk founder allele contributing to breast cancer in these two families. Sequencing of DNA and RNA from the two families did not detect any pathogenic mutations. Finally, 29 SNPs in the region were analyzed in 44,214 cases and 43,532 controls from BCAC, and the original haplotypes in the two families were suggested as low-risk alleles for European and Swedish women specifically. There was also some support for one additional independent moderate-risk allele in Swedish familial samples. The results were consistent with our previous findings in familial breast cancer and supported a breast cancer susceptibility locus at 6q14.1 around the PHIP gene.
نوع الوثيقة: article in journal/newspaper
اللغة: unknown
تدمد: 1949-2553
العلاقة: Oncotarget; Jiao, Xiang; Aravidis, Christos; Marikkannu, Rajeshwari; Rantala, Johanna; Picelli, Simone; Adamovic, Tatjana; Liu, Tao; Maguire, Paula; Kremeyer, Barbara; Luo, Liping; von Holst, Susanna; Kontham, Vinaykumar; Thutkawkorapin, Jessada; Margolin, Sara; Du, Quan; Lundin, Johanna; Michailidou, Kyriaki; Bolla, Manjeet K. Wang, Qin; Dennis, Joe; Lush, Michael; Ambrosone, Christine B.; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Beckmann, Matthias W.; Blomqvist, Carl; Blot, William; Boeckx, Bram; Bojesen, Stig E.; Bonanni, Bernardo; Brand, Judith S.; Brauch, Hiltrud; Brenner, Hermann; Broeks, Annegien; Brüning, Thomas; Burwinkel, Barbara; Cai, Qiuyin; Chang-Claude, Jenny; Collaborators, NBCS; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Deming-Halverson, Sandra L.; Devilee, Peter; dos-Santos-Silva, Isabel; Dörk, Thilo; Eriksson, Mikael; Fasching, Peter A.; Figueroa, Jonine; Flesch-Janys, Dieter; Flyger, Henrik; Gabrielson, Marike; García-Closas, Montserrat; Giles, Graham G.; González-Neira, Anna; Guénel, Pascal; Guo, Qi; Gündert, Melanie; Haiman, Christopher A.; Hallberg, Emily; Hamann, Ute; Harrington, Patricia; Hooning, Maartje J.; Hopper, John L.; Huang, Guanmengqian; Jakubowska, Anna; Jones, Michael E.; Kerin, Michael J.; Kosma, Veli-Matti; Kristensen, Vessela N.; Lambrechts, Diether; Marchand, Loic Le; Lubinski, Jan; Mannermaa, Arto; Martens, John W.M.; Meindl, Alfons; Milne, Roger L.; Mulligan, Anna Marie; Neuhausen, Susan L.; Nevanlinna, Heli; Peto, Julian; Pylkas, Katri; Radice, Paolo; Rhenius, Valerie; Sawyer, Elinor J.; Schmidt, Marjanka K.; Schmutzler, Rita K.; Seynaeve, Caroline; Shah, Mitul; Simard, Jacques; Southey, Melissa C.; Swerdlow, Anthony J.; Truong, Therese; Wendt, Camilla; Winqvist, Robert; Zheng, Wei; Investigators, kConFab/AOCS; Benitez, Javier; Dunning, Alison M.; Pharoah, Paul D.P.; Easton, Douglas F.; Czene, Kamila; Hall, Per; Lindblom, Annika (2017). phip - a novel candidate breast cancer susceptibility locus on 6q14.1. Oncotarget 8 (61), 102769-102782; http://hdl.handle.net/10379/12095Test
DOI: 10.18632/oncotarget.21800
الإتاحة: https://doi.org/10.18632/oncotarget.21800Test
http://hdl.handle.net/10379/12095Test
حقوق: Attribution-NonCommercial-NoDerivs 3.0 Ireland ; https://creativecommons.org/licenses/by-nc-nd/3.0/ieTest/
رقم الانضمام: edsbas.73D057FD
قاعدة البيانات: BASE
الوصف
تدمد:19492553
DOI:10.18632/oncotarget.21800