Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease
| العنوان: | Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease |
|---|---|
| المؤلفون: | Schwimmer, Jeffrey B, Zepeda, Anne, Newton, Kimberly P, Xanthakos, Stavra A, Behling, Cynthia, Hallinan, Erin K, Donithan, Michele, Tonascia, James, Nonalcoholic Steatohepatitis Clinical Research Network |
| المساهمون: | Sookoian, Silvia C |
| المصدر: | PloS one, vol 9, iss 11 PLoS ONE, Vol 9, Iss 11, p e112569 (2014) PLoS ONE |
| بيانات النشر: | eScholarship, University of California, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, medicine.medical_treatment, lcsh:Medicine, Nonalcoholic Steatohepatitis, Cardiovascular, Gastroenterology, Diagnostic Radiology, Hepatitis, Cohort Studies, Risk Factors, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, Medicine and Health Sciences, Prevalence, Insulin, lcsh:Science, Child, 2. Zero hunger, Pediatric, Multidisciplinary, Liver Diseases, Radiology and Imaging, Liver Disease, Fatty liver, Magnetic Resonance Imaging, 3. Good health, Cholesterol, Child, Preschool, Hypertension, Nonalcoholic Steatohepatitis Clinical Research Network, Female, Risk assessment, Cohort study, Research Article, medicine.medical_specialty, Pediatric Research Initiative, Adolescent, General Science & Technology, Clinical Trials and Supportive Activities, Chronic Liver Disease and Cirrhosis, Gastroenterology and Hepatology, Risk Assessment, Childhood obesity, LDL, Diagnostic Medicine, Clinical Research, Internal medicine, medicine, Humans, Preschool, Chi-Square Distribution, business.industry, Prevention, lcsh:R, nutritional and metabolic diseases, Blood Pressure Determination, Cholesterol, LDL, medicine.disease, digestive system diseases, United States, Uric Acid, Fatty Liver, Endocrinology, Blood pressure, Good Health and Well Being, Logistic Models, National Institutes of Health (U.S.), lcsh:Q, Steatosis, business, Digestive Diseases |
| الوصف: | Objective Nonalcoholic fatty liver disease (NAFLD) affects 9.6% of children and may put these children at elevated risk of high blood pressure and subsequent cardiovascular morbidity and mortality. Therefore, we sought to determine the prevalence of and risk factors for high blood pressure in children with NAFLD. Methods Cohort study performed by the NIDDK NASH Clinical Research Network. There were 484 children with NAFLD ages 2 to 17 at enrollment; 382 children were assessed both at enrollment and 48 weeks afterwards. The main outcomes were high blood pressure at baseline and persistent high blood pressure at both baseline and 48 weeks. Results Prevalence of high blood pressure at baseline was 35.8% and prevalence of persistent high blood pressure was 21.4%. Children with high blood pressure were significantly more likely to have worse steatosis than children without high blood pressure (mild 19.8% vs. 34.2%, moderate 35.0% vs. 30.7%, severe 45.2% vs. 35.1%; P = 0.003). Higher body mass index, low-density lipoprotein, and uric acid were independent risk factors for high blood pressure (Odds Ratios: 1.10 per kg/m2, 1.09 per 10 mg/dL, 1.25 per mg/dL, respectively). Compared to boys, girls with NAFLD were significantly more likely to have persistent high blood pressure (28.4% vs.18.9%; P = 0.05). Conclusions In conclusion, NAFLD is a common clinical problem that places children at substantial risk for high blood pressure, which may often go undiagnosed. Thus blood pressure evaluation, control, and monitoring should be an integral component of the clinical management of children with NAFLD. |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822a33522de43d11a63c6687ac1448f2Test https://escholarship.org/uc/item/7236n8z6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....822a33522de43d11a63c6687ac1448f2 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |