Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor (VEGF)-mediated angiogenesis is determined by their sizes
| العنوان: | Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor (VEGF)-mediated angiogenesis is determined by their sizes |
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| المؤلفون: | Jin Hyoung Kim, Dong Hyun Jo, Jin Gyeong Son, Yuanze Piao, Tae Geol Lee, Jeong Hun Kim |
| المصدر: | Nano Research. 7:844-852 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Materials science, biology, Angiogenesis, VEGF receptors, Nanoparticle, Nanotechnology, Condensed Matter Physics, Inhibitory postsynaptic potential, medicine.disease_cause, Atomic and Molecular Physics, and Optics, Vascular endothelial growth factor, chemistry.chemical_compound, chemistry, Apoptosis, In vivo, medicine, biology.protein, Biophysics, General Materials Science, Electrical and Electronic Engineering, Oxidative stress |
| الوصف: | Nanoparticles can be involved in biological activities such as apoptosis, angiogenesis, and oxidative stress by themselves. In particular, inorganic nanoparticles such as gold and silica nanoparticles are known to inhibit vascular endothelial growth factor (VEGF)-mediated pathological angiogenesis. In this study, we show that anti-angiogenic effect of inorganic nanospheres is determined by their sizes. We demonstrate that 20 nm size gold and silica nanospheres suppress VEGF-induced activation of VEGF receptor-2, in vitro angiogenesis, and in vivo pathological angiogenesis more efficiently than their 100 nm size counterparts. Our results suggest that modulation of the size of gold and silica nanospheres determines their inhibitory activity to VEGF-mediated angiogenesis. |
| تدمد: | 1998-0000 1998-0124 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::767eb769a01107a854852e2a96124956Test https://doi.org/10.1007/s12274-014-0445-8Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........767eb769a01107a854852e2a96124956 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19980000 19980124 |
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