دورية أكاديمية
Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia
| العنوان: | Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia |
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| المؤلفون: | Zania Diabasana, Jeanne-Marie Perotin, Randa Belgacemi, Julien Ancel, Pauline Mulette, Claire Launois, Gonzague Delepine, Xavier Dubernard, Jean-Claude Mérol, Christophe Ruaux, Philippe Gosset, Uwe Maskos, Myriam Polette, Gaëtan Deslée, Valérian Dormoy |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 6657, p 6657 (2021) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | rs16969968, airway epithelial cells, differentiation, remodelling, inflammation, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The gene cluster region, CHRNA3/CHRNA5/CHRNB4, encoding for nicotinic acetylcholine receptor (nAChR) subunits, contains several genetic variants linked to nicotine addiction and brain disorders. The CHRNA5 single-nucleotide polymorphism (SNP) rs16969968 is strongly associated with nicotine dependence and lung diseases. Using immunostaining studies on tissue sections and air-liquid interface airway epithelial cell cultures, in situ hybridisation, transcriptomic and cytokines detection, we analysed rs16969968 contribution to respiratory airway epithelial remodelling and modulation of inflammation. We provide cellular and molecular analyses which support the genetic association of this polymorphism with impaired ciliogenesis and the altered production of inflammatory mediators. This suggests its role in lung disease development. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/22/13/6657Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test; https://doaj.org/article/5e15fdb6c8704492bb673d687d9555f8Test |
| DOI: | 10.3390/ijms22136657 |
| الإتاحة: | https://doi.org/10.3390/ijms22136657Test https://doaj.org/article/5e15fdb6c8704492bb673d687d9555f8Test |
| رقم الانضمام: | edsbas.6FE1DD25 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms22136657 |