يعرض 1 - 10 نتائج من 193 نتيجة بحث عن '"Glucagon-Like Peptide-1 Receptor"', وقت الاستعلام: 1.53s تنقيح النتائج
  1. 1
    Exenatide extended release in patients with type 1 diabetes with and without residual insulin production

    المؤلفون: Kevan C. Herold, Peter A. Gottlieb, Louis H. Philipson, James Dziura, David A. Baidal, Ruth S. Weinstock, Jason L. Gaglia, Rodica Pop-Busui, Jennifer B. Marks, Stephen E. Gitelman, Jesse Reynolds

    المصدر: Diabetes, obesity & metabolism, vol 22, iss 11
    Diabetes Obes Metab

    مصطلحات موضوعية: Glycated Hemoglobin A, type 1 diabetes, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030204 cardiovascular system & hematology, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Insulin, Pediatric, C-peptide, Diabetes, 5.1 Pharmaceuticals, 6.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Type 2, Type 1, medicine.drug, medicine.medical_specialty, adjunctive therapy, glucagon-like peptide-1 receptor agonist, Clinical Trials and Supportive Activities, Clinical Sciences, 030209 endocrinology & metabolism, Placebo, Article, Endocrinology & Metabolism, 03 medical and health sciences, Clinical Research, Internal medicine, Diabetes Mellitus, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Adverse effect, Metabolic and endocrine, Glucagon-like peptide 1 receptor, Glycated Hemoglobin, Type 1 diabetes, Venoms, business.industry, Evaluation of treatments and therapeutic interventions, medicine.disease, Confidence interval, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, chemistry, Exenatide, business

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c923f3404bac8533ff93ea3c5316afTest
    https://doi.org/10.1111/dom.14121Test


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  2. 2
    Exendin‐4, a GLP‐1 receptor agonist regulates retinal capillary tone and restores microvascular patency after ischaemia–reperfusion injury

    المؤلفون: Xiangmei Kong, Jihong Wu, Xinghuai Sun, Huan Xu, Fang-Yuan Hu, Ruyi Zhai

    المصدر: British Journal of Pharmacology

    مصطلحات موضوعية: 0301 basic medicine, Agonist, endocrine system, Endothelium, medicine.drug_class, Pharmacology, Endothelial NOS, Glucagon-Like Peptide-1 Receptor, Retina, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, Receptor, Venoms, Chemistry, digestive, oral, and skin physiology, Endothelial Cells, Retinal, Receptor antagonist, Research Papers, Capillaries, 030104 developmental biology, medicine.anatomical_structure, Reperfusion Injury, Exenatide, Perfusion, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery, Research Paper

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa0852506092c00f688a88f4c3a760cTest
    https://doi.org/10.1111/bph.15059Test


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  3. 3
    Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

    المؤلفون: Caroline A. Hick, Juan Carlos Mobarec, Patrick M. Sexton, Thomas P. Sakmar, Cassandra Koole, Christopher A. Reynolds

    المصدر: The Journal of Biological Chemistry

    مصطلحات موضوعية: 0301 basic medicine, photocross-linking, Peptide, Ligands, Biochemistry, structure-function, 0302 clinical medicine, Cyclic AMP, structural biology, 5-HT5A receptor, Receptor, chemistry.chemical_classification, Molecular Structure, genetic code expansion, Protein Structure and Folding, glucagon-like peptide-1 receptor (GLP-1R), Azides, Ultraviolet Rays, Phenylalanine, Protein domain, G protein-coupled receptor (GPCR), Biology, Molecular Dynamics Simulation, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Structure-Activity Relationship, Protein Domains, Humans, unnatural amino acid, GABBR2, GABBR1, Molecular Biology, G protein-coupled receptor, Binding Sites, peptide hormone, molecular modeling, Venoms, Cell Biology, 030104 developmental biology, HEK293 Cells, Structural biology, chemistry, Diabetes Mellitus, Type 2, Mutagenesis, Mutation, Biophysics, Exenatide, Protein Multimerization, Peptides, 030217 neurology & neurosurgery

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf16e26034aacee8551f6377dd783e8Test
    http://europepmc.org/articles/PMC5409479Test


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  4. 4
    GLP-1 receptor agonists downregulate aberrant GnT-III expression in Alzheimer's disease models through the Akt/GSK-3β/β-catenin signaling

    المؤلفون: Xiangdong Gao, Wenbing Yao, Song Chen, Su-Ting Chen, Zheng Xu, Ying Wang

    المصدر: Neuropharmacology. 131:190-199

    مصطلحات موضوعية: Male, 0301 basic medicine, endocrine system, Cell Survival, Down-Regulation, Mice, Transgenic, N-Acetylglucosaminyltransferases, PC12 Cells, Neuroprotection, Glucagon-Like Peptide-1 Receptor, Amyloid beta-Protein Precursor, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, Alzheimer Disease, Presenilin-1, Animals, LY294002, Enzyme Inhibitors, RNA, Small Interfering, Maze Learning, Receptor, Protein kinase B, Glucagon-like peptide 1 receptor, Pharmacology, Memory Disorders, Venoms, Chemistry, Rats, Oncogene Protein v-akt, Disease Models, Animal, 030104 developmental biology, Cancer research, Exenatide, Phosphorylation, Signal transduction, Peptides, 030217 neurology & neurosurgery, Signal Transduction

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73cc3165d551570350440a13f990cd1Test
    https://doi.org/10.1016/j.neuropharm.2017.11.048Test


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  5. 5
    Evaluation of Drug Efficacy of GLP-1 Receptor Agonists and DPP-4 Inhibitors Based on Target Molecular Binding Occupancy

    المؤلفون: Koji Kimura, Risa Takayanagi, Takumi Uchida, Yasuhiko Yamada

    المصدر: Biological and Pharmaceutical Bulletin. 41:153-157

    مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, endocrine system, Pyrrolidines, Pharmaceutical Science, Adamantane, 030209 endocrinology & metabolism, Pharmacology, Ligands, Glucagon-Like Peptide-1 Receptor, Efficacy, 03 medical and health sciences, Lixisenatide, chemistry.chemical_compound, 0302 clinical medicine, Piperidines, Nitriles, medicine, Humans, Hypoglycemic Agents, Vildagliptin, Molecular Targeted Therapy, Uracil, Receptor, Glucagon-like peptide 1 receptor, Glycated Hemoglobin, Dipeptidyl-Peptidase IV Inhibitors, Dose-Response Relationship, Drug, Venoms, Liraglutide, Sitagliptin Phosphate, digestive, oral, and skin physiology, Reproducibility of Results, General Medicine, 030104 developmental biology, Diabetes Mellitus, Type 2, chemistry, Hyperglycemia, Exenatide, Drug Monitoring, Peptides, Algorithms, Alogliptin, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c481ea0e69ef49a1b7fc3f5295cc4f5aTest
    https://doi.org/10.1248/bpb.b17-00237Test


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  6. 6
    The Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 Inhibits Lipopolysaccharide-Induced Osteoclast Formation and Bone Resorption via Inhibition of TNF-αExpression in Macrophages

    المؤلفون: Keisuke Kimura, Jiawei Qi, Hideki Kitaura, Haruki Sugisawa, Akiko Kishikawa, Kazuhiro Shima, Masahiko Ishida, Wei Ren Shen, Saika Ogawa

    المصدر: Journal of Immunology Research
    Journal of Immunology Research, Vol 2018 (2018)

    مصطلحات موضوعية: Lipopolysaccharides, Male, 0301 basic medicine, Anti-Inflammatory Agents, Osteoclasts, Mice, 0302 clinical medicine, Immunology and Allergy, Receptor, Cells, Cultured, biology, Chemistry, digestive, oral, and skin physiology, Cell Differentiation, General Medicine, medicine.anatomical_structure, RANKL, lipids (amino acids, peptides, and proteins), Tumor necrosis factor alpha, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, Research Article, lcsh:Immunologic diseases. Allergy, musculoskeletal diseases, Agonist, endocrine system, medicine.medical_specialty, Article Subject, medicine.drug_class, Immunology, 030209 endocrinology & metabolism, Inflammation, Glucagon-Like Peptide-1 Receptor, Bone resorption, 03 medical and health sciences, Osteoclast, Internal medicine, medicine, Animals, Bone Resorption, Glucagon-like peptide 1 receptor, Tumor Necrosis Factor-alpha, Venoms, Macrophages, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, biology.protein, Exenatide, lcsh:RC581-607, Peptides

    وصف الملف: text/xhtml

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cc6180f5bd6b51db956a01f0997ab8Test
    https://doi.org/10.1155/2018/5783639Test


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  7. 7
    A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells

    المؤلفون: Paul Johnson, Alejandra Tomas, Stephen R. Bloom, Piero Marchetti, Phoebe C Douzenis, Lorenzo Piemonti, Guy A. Rutter, Domenico Bosco, A. M. James Shapiro, Pauline Chabosseau, Ben Jones, Ivan R. Corrêa, Teresa Buenaventura, N Kanda

    المساهمون: Medical Research Council, Buenaventura, Teresa, Kanda, Nisha, Douzenis, Phoebe C, Jones, Ben, Bloom, Stephen R, Chabosseau, Pauline, Corrêa, Ivan R, Bosco, Domenico, Piemonti, Lorenzo, Marchetti, Piero, Johnson, Paul R, Shapiro, Am Jame, Rutter, Guy A, Tomas, Alejandra, Pathology/molecular and cellular medicine

    المصدر: Diabetes, Vol. 67, No 3 (2018) pp. 385-399

    مصطلحات موضوعية: 0301 basic medicine, Glucagon-Like Peptide-1 Receptor/agonists/genetics/metabolism, SNX27, Endocrinology, Diabetes and Metabolism, Endocytic cycle, Incretins/pharmacology, Second Messenger Systems, Tissue Culture Techniques, Mice, Endocrinology, Insulin-Secreting Cells, Insulin Secretion, Cyclic AMP, Cyclic AMP/metabolism, Insulin, Receptor, Sorting Nexins, Peptides/pharmacology, Microscopy, ddc:617, Venoms/pharmacology, biology, Chemistry, digestive, oral, and skin physiology, 11 Medical And Health Sciences, Endocytosis, Cell biology, Diabetes and Metabolism, DNA-Binding Proteins, Calcium Signaling/drug effects, RNA Interference, hormones, hormone substitutes, and hormone antagonists, endocrine system, Insulin/metabolism, Lysosomes/drug effects/enzymology/metabolism/ultrastructure, Endosome, Recombinant Fusion Proteins, Internal Medicine, Endocytosis/drug effects, Electron, Incretins, Clathrin, DNA-Binding Proteins/antagonists & inhibitors/genetics/metabolism, Glucagon-Like Peptide-1 Receptor, Cell Line, Endocrinology & Metabolism, 03 medical and health sciences, Microscopy, Electron, Transmission, Second Messenger Systems/drug effects, Transmission, Animals, Humans, Calcium Signaling, Glucagon-like peptide 1 receptor, Venoms, 030104 developmental biology, biology.protein, Exenatide, Lysosomes, Peptides, Recombinant Fusion Proteins/chemistry/metabolism, Sorting Nexins/antagonists & inhibitors/genetics/metabolism, Insulin-Secreting Cells/drug effects/metabolism/ultrastructure

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3f1803ee2e9e82c99b109c69eb4fedTest
    https://doi.org/10.2337/db17-0639Test


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  8. 8
    Exenatide mitigated diet-induced vascular aging and atherosclerotic plaque growth in ApoE-deficient mice under chronic stress

    المؤلفون: Haiying Jiang, Limei Piao, Masafumi Kuzuya, Takeshi Sasaki, Lina Hu, Guangxian Zhao, Xian Wu Cheng, Kenji Okumura, Shinyu Ogasawara, Aiko Inoue, Yanna Lei, Wenhu Xu, Hongxian Wu, Chenglin Yu, Guang Yang

    المصدر: Atherosclerosis. 264:1-10

    مصطلحات موضوعية: Male, 0301 basic medicine, Apolipoprotein E, Apolipoprotein B, Mice, Knockout, ApoE, Adipose tissue, 030204 cardiovascular system & hematology, medicine.disease_cause, 0302 clinical medicine, Glucagon-Like Peptide 1, Chronic stress, Aorta, Cells, Cultured, Cellular Senescence, Foam cell, biology, Chemistry, Age Factors, Plaque, Atherosclerotic, Phenotype, Adiponectin, Inflammation Mediators, Cardiology and Cardiovascular Medicine, Signal Transduction, medicine.drug, medicine.medical_specialty, Dipeptidyl Peptidase 4, Aortic Diseases, Diet, High-Fat, Incretins, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Internal medicine, medicine, Animals, Genetic Predisposition to Disease, Venoms, Endothelial Cells, Atherosclerosis, Disease Models, Animal, Oxidative Stress, 030104 developmental biology, Endocrinology, Chronic Disease, Proteolysis, biology.protein, Exenatide, Peptides, Stress, Psychological, Oxidative stress, Foam Cells, Peptide Hydrolases

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e324b23b9a534bccb126971d4222fb4eTest
    https://doi.org/10.1016/j.atherosclerosis.2017.07.014Test


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  9. 9
    Prediction of thyroid C-cell carcinogenicity after chronic administration of GLP1-R agonists in rodents

    المؤلفون: Willem van den Brink, Francesco Bellanti, Jan Willem van der Laan, Annette Emerenciana, Oscar Della Pasqua

    المصدر: Toxicology and Applied Pharmacology. 320:51-59

    مصطلحات موضوعية: 0301 basic medicine, Agonist, endocrine system, Databases, Factual, medicine.drug_class, Rodentia, Pharmacology, Toxicology, Drug Administration Schedule, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Lixisenatide, chemistry.chemical_compound, Pharmacokinetics, Predictive Value of Tests, medicine, Animals, Hypoglycemic Agents, Potency, Thyroid Neoplasms, Venoms, business.industry, Liraglutide, Hyperplasia, medicine.disease, 030104 developmental biology, Nonlinear Dynamics, chemistry, Pharmacodynamics, Exenatide, Peptides, business, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fbd724f2dde3d9ffa20f950c449279Test
    https://doi.org/10.1016/j.taap.2017.02.010Test


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  10. 10
    Short-acting glucagon-like peptide-1 receptor agonists as add-on to insulin therapy in type 1 diabetes: A review

    المؤلفون: Anders Albér, Filip K. Knop, Andreas Brønden

    المصدر: Diabetes, Obesity and Metabolism. 19:915-925

    مصطلحات موضوعية: endocrine system, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Drug Resistance, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, Glycated Hemoglobin, Type 1 diabetes, Gastric emptying, Venoms, business.industry, digestive, oral, and skin physiology, Glucagon secretion, medicine.disease, Glucagon-like peptide-1, Hypoglycemia, Diabetes Mellitus, Type 1, Postprandial, Gastric Emptying, chemistry, Hyperglycemia, Adjunctive treatment, Exenatide, Drug Therapy, Combination, Glycated hemoglobin, Peptides, business, hormones, hormone substitutes, and hormone antagonists, Half-Life

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e512fe6d0d3f9607cbd2b80143bc1aTest
    https://doi.org/10.1111/dom.12911Test


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