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المؤلفون: Lachlan Clydesdale, Hari Venugopal, Peishen Zhao, Patrick M. Sexton, Alisa Glukhova, Arthur Christopoulos, Christopher A. Reynolds, Yi Lynn Liang, Xin Zhang, Tin T. Truong, Andrew N. Keller, Maryam Khoshouei, Matthew J. Belousoff, Karen J. Gregory, Giuseppe Deganutti, Radostin Danev, Denise Wootten, Katie Leach
المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Nature Communicationsمصطلحات موضوعية: Protein Conformation, alpha-Helical, Gene Expression, General Physics and Astronomy, Peptide, Ligands, chemistry.chemical_compound, Receptor pharmacology, G protein-coupled receptors, Glucagon-Like Peptide 1, Cloning, Molecular, Receptor, chemistry.chemical_classification, Multidisciplinary, digestive, oral, and skin physiology, Recombinant Proteins, Transmembrane domain, Oxyntomodulin, Baculoviridae, hormones, hormone substitutes, and hormone antagonists, Protein Binding, Agonist, endocrine system, medicine.drug_class, G protein, Science, Genetic Vectors, Allosteric regulation, Molecular Dynamics Simulation, Glucagon-Like Peptide-1 Receptor, Article, General Biochemistry, Genetics and Molecular Biology, Structure-Activity Relationship, Allosteric Regulation, Electron microscopy, medicine, Humans, Protein Interaction Domains and Motifs, Binding Sites, Cryoelectron Microscopy, Mutagenesis, General Chemistry, Kinetics, HEK293 Cells, chemistry, Mutation, Biophysics, Exenatide, Protein Conformation, beta-Strand
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5aa9dcac923a091ce55a4b69969de5Test
https://doaj.org/article/8f7e8894b23a4f8eb32f5d2c26ccefc6Test -
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المؤلفون: Sarah J. Piper, Xin Zhang, Christopher J. Langmead, Patrick M. Sexton, Radostin Danev, Rachel M. Johnson, Teresa H. Vandekolk, Denise Wootten, Theodore J. Nettleton
المصدر: Biochemical and Biophysical Research Communications. 578:84-90
مصطلحات موضوعية: chemistry.chemical_classification, Agonist, endocrine system, Gs alpha subunit, medicine.drug_class, Cryoelectron Microscopy, digestive, oral, and skin physiology, Biophysics, Incretin, Peptide, Cell Biology, Biochemistry, Glucagon-Like Peptide-1 Receptor, Transmembrane domain, Protein Domains, chemistry, Extracellular, medicine, Protein Structural Elements, Gastric inhibitory polypeptide receptor, Peptides, Receptor, Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac9a2f200cf87384e80ba3421a510a2Test
https://doi.org/10.1016/j.bbrc.2021.09.016Test -
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المؤلفون: Edin Begic, Mirsada Causevic
المصدر: Heart, Lung and Circulation. 30:1675-1680
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, chemistry.chemical_classification, Glucose lowering, business.industry, Brain, Cardiovascular Agents, Peptide, Pharmacology, Atherosclerosis, medicine.disease, Glucagon-like peptide-1, Thrombosis, Glucagon-Like Peptide-1 Receptor, Diabetes Mellitus, Type 2, chemistry, Cardiovascular Diseases, medicine, Humans, Endothelial dysfunction, Cardiology and Cardiovascular Medicine, Vascular function, Receptor, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9375dbfd56aef15bd089bf8f5cac1de1Test
https://doi.org/10.1016/j.hlc.2021.07.024Test -
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المؤلفون: Seyed Ebrahim Alavi, Hasan Ebrahimi Shahmabadi
المصدر: Drug Discovery Today. 26:1936-1943
مصطلحات موضوعية: 0301 basic medicine, endocrine system, Peptide, Disease, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Glucagon-Like Peptide 1, Insulin-Secreting Cells, Diabetes mellitus, Drug Discovery, Diabetes Mellitus, Animals, Humans, Hypoglycemic Agents, Insulin, Medicine, Receptor, Pharmacology, chemistry.chemical_classification, biology, business.industry, digestive, oral, and skin physiology, medicine.disease, Glucagon-like peptide-1, Insulin receptor, Glucose, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Drug delivery, Cancer research, biology.protein, Beta cell, business, hormones, hormone substitutes, and hormone antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876b63ff2ae83bdb02da4773765b4da4Test
https://doi.org/10.1016/j.drudis.2021.03.032Test -
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المؤلفون: Chen Li, Jie Shi, Lei Nie, Yuntian Xie, Haofei Hong, Zhimeng Wu, Shijie Dai, Kun Zhou, Kai Zhao, Zhifang Zhou
المصدر: Journal of Medicinal Chemistry. 64:4947-4959
مصطلحات موضوعية: Blood Glucose, Agonist, medicine.drug_class, chemical and pharmacologic phenomena, Peptide, Antigen-Antibody Complex, Pharmacology, Antibodies, Glucagon-Like Peptide-1 Receptor, Diabetes Mellitus, Experimental, Mice, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Hypoglycemic Agents, Amino Acid Sequence, Receptor, chemistry.chemical_classification, Chemistry, Glucose Tolerance Test, In vitro, Mice, Inbred C57BL, Dinitrobenzenes, Liver, Drug Design, Exenatide, Molecular Medicine, Female, Dinitrophenyl, Haptens, Hapten, Half-Life, Conjugate
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2aea996bd5d20585afbac96d2077415Test
https://doi.org/10.1021/acs.jmedchem.1c00032Test -
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المؤلفون: Jonathan D Douros, Barent DuBois, Bin Yang, Brian Finan, Diego Perez-Tilve, Jay Levy, Vasily M. Gelfanov, John P. Mayer, Richard D. DiMarchi, Rebecca Rohlfs
المصدر: Journal of Medicinal Chemistry. 64:4697-4708
مصطلحات موضوعية: Blood Glucose, Male, Injections, Subcutaneous, Peptide, Pharmacology, 01 natural sciences, Glucagon, Glucagon-Like Peptide-1 Receptor, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Amide, Drug Discovery, Aspartic acid, Cyclic AMP, Receptors, Glucagon, Animals, Humans, Potency, Amino Acid Sequence, IC50, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Chemistry, Antagonist, Amides, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Solubility, Molecular Medicine, Peptides, hormones, hormone substitutes, and hormone antagonists, Half-Life, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783a6f3105e42ace8da70edf126a8b42Test
https://doi.org/10.1021/acs.jmedchem.0c02069Test -
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المؤلفون: Xiaoyuan Chen, Yaping Luo
المصدر: PET Clinics. 16:205-217
مصطلحات موضوعية: Diagnostic Imaging, endocrine system, endocrine system diseases, Peptide, Bioinformatics, medicine.disease_cause, Glucagon-Like Peptide-1 Receptor, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, Receptor, Hyperinsulinemic hypoglycemia, Insulinoma, chemistry.chemical_classification, Radiation, business.industry, digestive, oral, and skin physiology, General Medicine, medicine.disease, Pancreatic Neoplasms, chemistry, 030220 oncology & carcinogenesis, Exenatide, business, hormones, hormone substitutes, and hormone antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58174fe3cff9d3a2fa64e552f498ff40Test
https://doi.org/10.1016/j.cpet.2020.12.008Test -
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المؤلفون: Punit P. Seth, Johan Broddefalk, Patrik U. Andersson, Johan Meuller, Michael E. Østergaard, Thazha P. Prakash, Linda Sundström, Leonardo De Maria, Wuxia Fu, Ahlke Hayen, David Janzén, Carina Ämmälä, Eric Valeur, Laurent Knerr, Maria Ölwegård-Halvarsson, Richard G. Lee, Shalini Andersson, William J. Drury, Elaine Pirie, Mehran Nikan, Rasmus Jansson-Löfmark
المصدر: Journal of the American Chemical Society. 143:3416-3429
مصطلحات موضوعية: Agonist, medicine.drug_class, Peptide, 010402 general chemistry, 01 natural sciences, Biochemistry, Glucagon-Like Peptide-1 Receptor, Catalysis, Structure-Activity Relationship, Colloid and Surface Chemistry, In vivo, Insulin-Secreting Cells, medicine, Animals, Humans, Amino Acid Sequence, RNA, Messenger, Receptor, Peptide sequence, chemistry.chemical_classification, Drug Carriers, Molecular Structure, Oligonucleotide, HEK 293 cells, General Chemistry, Oligonucleotides, Antisense, Islet Amyloid Polypeptide, 0104 chemical sciences, Mice, Inbred C57BL, HEK293 Cells, chemistry, Cancer research, Beta cell, Peptides
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b854feb4ca478194b8ccb06db2a2c928Test
https://doi.org/10.1021/jacs.0c12043Test -
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المؤلفون: Christian L. Roth, Oleg G. Chepurny, Bart C. De Jonghe, George G. Holz, Clinton Elfers, Kylie S. Chichura, Matthew R. Hayes, Tito Borner, Robert P. Doyle, Ian R. Sweet, Brandon T. Milliken
المصدر: J Med Chem
مصطلحات موضوعية: Blood Glucose, Male, Models, Molecular, Vomiting, Nausea, Neuropeptide, Peptide, Type 2 diabetes, Pharmacology, Binding, Competitive, 01 natural sciences, Article, Glucagon-Like Peptide-1 Receptor, Rats, Sprague-Dawley, Islets of Langerhans, Structure-Activity Relationship, 03 medical and health sciences, Weight loss, In vivo, Insulin Secretion, Weight Loss, Drug Discovery, medicine, Animals, Humans, Peptide YY, Receptor, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Shrews, medicine.disease, In vitro, Rats, Receptors, Neuropeptide Y, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Glucose, chemistry, Microsomes, Liver, Exenatide, Molecular Medicine, medicine.symptom
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f87628e79fa1735fd176ff82760e989Test
https://doi.org/10.1021/acs.jmedchem.0c01783Test -
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المؤلفون: R Andres Parra Sperberg, Stephanie Hanna, Bradley L. Pentelute, Po-Ssu Huang, Chelsea K Longwell, Nina Hartrampf, Jennifer R. Cochran
المصدر: ACS Chem Biol
مصطلحات موضوعية: Agonist, endocrine system, Arginine, medicine.drug_class, Peptide, Ligands, Biochemistry, Glucagon-Like Peptide-1 Receptor, Article, Structure-Activity Relationship, Peptide Library, medicine, Hypoglycemic Agents, Amino Acid Sequence, Saturated mutagenesis, Receptor, G protein-coupled receptor, chemistry.chemical_classification, Cryoelectron Microscopy, digestive, oral, and skin physiology, Wild type, General Medicine, Amino acid, chemistry, Mutagenesis, Drug Design, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e4038d4cceef44f9ea7c6e7f217ec8Test
https://doi.org/10.1021/acschembio.0c00722Test