Metabolic Reprogramming in CD8+ T Cells During Acute Viral Infections
| العنوان: | Metabolic Reprogramming in CD8+ T Cells During Acute Viral Infections |
|---|---|
| المؤلفون: | Shubhranshu S. Gupta, Jin Wang, Min Chen |
| المصدر: | Frontiers in Immunology Frontiers in Immunology, Vol 11 (2020) |
| بيانات النشر: | Frontiers Media SA, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, 0301 basic medicine, Cell signaling, glutaminolysis, Mini Review, viral infections, T cell, Immunology, CD8-Positive T-Lymphocytes, Biology, CD8+ T cells, Lymphocyte Activation, Epigenesis, Genetic, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Animals, Humans, Immunology and Allergy, Cytotoxic T cell, Glycolysis, Epigenetics, fatty acid oxidation, Glutaminolysis, epigenetics, glycolysis, Cellular Reprogramming, Cell biology, Phenotype, 030104 developmental biology, medicine.anatomical_structure, Virus Diseases, Acute Disease, Host-Pathogen Interactions, Viruses, lcsh:RC581-607, Energy Metabolism, metabolism, Immunologic Memory, CD8, 030215 immunology |
| الوصف: | CD8+ T cells represent one of the most versatile immune cells critical for clearing away viral infections. Due to their important role, CD8+ T cell activation and memory formation during viral infection have been the focus of several studies recently. Although CD8+ T cell activation and memory formation have been associated with metabolic alterations, the molecular understanding behind T cells choosing one type of metabolism over others based on their differentiation stage is still unclear. This review focuses on how the signaling molecules and cellular processes that are characteristic of CD8+ T cell activation and memory formation also play a critical role in selecting specific type of metabolism during viral infections. In addition, we will summarize the epigenetic factors regulating these metabolic alterations. |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af48832f641a58921e25173fe9816d67Test https://doi.org/10.3389/fimmu.2020.01013Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....af48832f641a58921e25173fe9816d67 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
|---|