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المؤلفون: Boonen, Rick A C M, Wiegant, Wouter W, Celosse, Nandi, Vroling, Bas, Heijl, Stephan, Kote-Jarai, Zsofia, Mijuskovic, Martina, Cristea, Simona, Solleveld-Westerink, Nienke, van Wezel, Tom, Beerenwinkel, Niko, Eeles, Rosalind, Devilee, Peter, Vreeswijk, Maaike P G, Marra, Giancarlo, van Attikum, Haico
المساهمون: University of Zurich, van Attikum, Haico
المصدر: Cancer Research, 82 (4)
Cancer Research, 82(4), 615-631. AMER ASSOC CANCER RESEARCHمصطلحات موضوعية: Male, Mice, Knockout, Cancer Research, Mice, 129 Strain, 10061 Institute of Molecular Cancer Research, Mutation, Missense, Prostatic Neoplasms, 610 Medicine & health, Breast Neoplasms, Pedigree, Checkpoint Kinase 2, Oncology, Risk Factors, Neoplasms, 570 Life sciences, biology, Animals, Humans, 2730 Oncology, 1306 Cancer Research, Female, Genetic Predisposition to Disease, skin and connective tissue diseases, Cells, Cultured
وصف الملف: application/pdf; application/application/pdf; Functional_Analysis_Identifies_Damaging_CHEK2_Missense_Variants_Associated_with_Increased_Cancer_Risk.pdf - application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5366d9302b7f65035ddfaa5aff5f71eTest
https://doi.org/10.1158/0008-5472.can-21-1845Test -
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المؤلفون: Hongyu Ding, YongJie Xu, Ronggui Hu, Xiangyan Zhang, Hui Chen, Yingjie Nie, LiLing Gu, Runsang Pan, Yun Yang, Chuanyin Li, Fang Liu
المصدر: Molecular Oncology, Vol 15, Iss 12, Pp 3738-3752 (2021)
Molecular Oncologyمصطلحات موضوعية: Cancer Research, Ubiquilin 4, Cell cycle checkpoint, DNA repair, DNA damage, Autophagosome maturation, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, BCL2A1, Genetics, Animals, Humans, Phosphorylation, Checkpoint Kinase 2, Research Articles, RC254-282, Mammals, biology, Kinase, Chemistry, Tumor Suppressor Proteins, Cell Cycle, Nuclear Proteins, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, General Medicine, Cell biology, DNA-Binding Proteins, Oncology, BCL2L10, ATM, mesothelioma, Molecular Medicine, biology.gene, Apoptosis Regulatory Proteins, Carrier Proteins, UBQLN4, DNA Damage, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19e2b11561c135e914cc7616bd3d023Test
https://doaj.org/article/c30d625dab974349afe266e11ed47685Test -
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المؤلفون: Daolin Tang, Xinxin Song, Muriel Mari, Vikramjit Lahiri, Daniel J. Klionsky, Zehan Hu, Wayne D. Hawkins, Shree Padma Metur, Elizabeth Delorme-Axford, Janakraj Bhattarai, Fulvio Reggiori, Joern Dengjel
المساهمون: Center for Liver, Digestive and Metabolic Diseases (CLDM), Microbes in Health and Disease (MHD)
المصدر: Autophagy
Autophagy, 18(7), 1694-1714. Taylor & Francis Groupمصطلحات موضوعية: Autophagosome, Saccharomyces cerevisiae Proteins, Atg1, Autophagy, Autophagy-Related Proteins, Cellular homeostasis, Cell Cycle Proteins, Nutrients, Saccharomyces cerevisiae, Cell Biology, ULK2, ULK1, Biology, Cell biology, DEAD-box RNA Helicases, Checkpoint Kinase 2, Gene Expression Regulation, Fungal, Autophagy-Related Protein-1 Homolog, Protein Kinases, Molecular Biology, Flux (metabolism), Post-transcriptional regulation, Research Paper
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cbbc535bf9b2ce560f0d2555700d6b4Test
https://doi.org/10.1080/15548627.2021.1997305Test -
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المؤلفون: Ragini Singh, Mohit Rajput, Rana P. Singh
المصدر: Mitochondrion. 61:114-124
مصطلحات موضوعية: Cell Survival, DNA damage, DNA repair, Apoptosis, HL-60 Cells, Ataxia Telangiectasia Mutated Proteins, Mitochondrion, stomatognathic system, Humans, Molecular Biology, Cell Proliferation, Ku70, biology, Weightlessness, Chemistry, Cell growth, Cell Biology, Mitochondria, Proliferating cell nuclear antigen, Cell biology, Checkpoint Kinase 2, Cell culture, Checkpoint Kinase 1, biology.protein, Molecular Medicine, Reactive Oxygen Species, DNA Damage
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6b721f84fb407c2970c73f4e9c1e8bTest
https://doi.org/10.1016/j.mito.2021.09.006Test -
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المؤلفون: Risa Karakida Kawaguchi, Yi-Jun Sheu, Bruce Stillman, Jesse Gillis
المصدر: eLife. 11
مصطلحات موضوعية: DNA Replication, Saccharomyces cerevisiae Proteins, DNA replication initiation, General Immunology and Microbiology, General Neuroscience, Cell Cycle, Promoter, Cell Cycle Proteins, General Medicine, Saccharomyces cerevisiae, Cell Cycle Checkpoints, Cell cycle, Biology, Protein Serine-Threonine Kinases, General Biochemistry, Genetics and Molecular Biology, Chromatin, Cell biology, Checkpoint Kinase 2, Transcription (biology), Gene expression, Phosphorylation, Gene, Transcription factor, DNA Damage
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfa757580f360ab4d2ff026b8c5ca5cTest
https://pubmed.ncbi.nlm.nih.gov/36520028Test -
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المؤلفون: A. V. Pushkarev, M. G. Galeev, V. A. Pushkarev, A. V. Sultanbaev
المصدر: Креативная хирургия и онкология, Vol 11, Iss 2, Pp 157-165 (2021)
مصطلحات موضوعية: 0301 basic medicine, Genome instability, RD1-811, DNA repair, Biology, malignant neoplasms, medicine.disease_cause, 03 medical and health sciences, brca2 gene, 0302 clinical medicine, Germline mutation, patched-1 receptor, medicine, skin and connective tissue diseases, CHEK2, RC254-282, checkpoint kinase 2, Point mutation, brca1 gene, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cancer, neoplastic genes, General Medicine, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, germline mutations, Surgery, Carcinogenesis, Ovarian cancer, carcinogenesis
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27f2c226d2b151c04fcf0078d487998Test
https://doi.org/10.24060/2076-3093-2021-11Test-2 -157-165 -
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المؤلفون: Taichi Hagio, Seiichi Mori, Sayuri Amino, Takeshi Nakajima, Tetsuo Noda, Tomoko Kaneyasu, Seigo Nakamura, Masaaki Matsuura, Tomo Osako, Noriko Yaguchi, Toru Hirota, Eri Nakashima, Dai Kitagawa, Takayuki Ueno, Reiko Yoshida, Osamu Gotoh, Norio Tanaka, Shinji Ohno, Yoshio Miki, Shunji Takahashi
المصدر: Cancer Science
مصطلحات موضوعية: Genetics, Genomics and Proteomics, 0301 basic medicine, Cancer Research, variants of uncertain significance, DNA Mutational Analysis, Datasets as Topic, Ataxia Telangiectasia Mutated Proteins, Loss of heterozygosity, 0302 clinical medicine, Exome, Breast, Homologous Recombination, Mastectomy, Exome sequencing, Genetics, BRCA1 Protein, Lasso logistic regression, General Medicine, Middle Aged, hereditary breast and ovarian cancer syndrome, Oncology, homologous recombination deficiency, 030220 oncology & carcinogenesis, Female, Original Article, Fanconi Anemia Complementation Group N Protein, Adult, PALB2, Breast Neoplasms, Biology, 03 medical and health sciences, Germline mutation, Breast cancer, Exome Sequencing, Biomarkers, Tumor, BRCAness, medicine, Humans, Genetic Predisposition to Disease, Genetic Testing, Allele, Germ-Line Mutation, Aged, BRCA2 Protein, Models, Genetic, Original Articles, medicine.disease, Checkpoint Kinase 2, 030104 developmental biology, Ovarian cancer
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376ea8b3a6a9aaa8a778b0ed5b65fb15Test
https://doi.org/10.1111/cas.14803Test -
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المؤلفون: Lei Zhang, Peike Peng, Weicheng Wu, Jianxin Gu, Yuanyuan Ruan, Hao Wu, Ying-Hong Shi, Jia Fan, Shushu Song, Lei Chang
المصدر: Gut. 70:2159-2171
مصطلحات موضوعية: Male, 0301 basic medicine, Hepatitis B virus, Programmed cell death, Carcinoma, Hepatocellular, Carcinogenesis, Mice, Nude, Apoptosis, Nerve Tissue Proteins, Biology, Endoplasmic Reticulum, medicine.disease_cause, Malignant transformation, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, medicine, Animals, Humans, Mice, Inbred BALB C, Cell growth, Liver Neoplasms, Gastroenterology, Membrane Proteins, digestive system diseases, Checkpoint Kinase 2, 030104 developmental biology, Reticulon, 030220 oncology & carcinogenesis, Hepatocytes, Cancer research, Tumor Suppressor Protein p53, Signal transduction, Carrier Proteins
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08af016146c39156651989cdaf664092Test
https://doi.org/10.1136/gutjnl-2020-321386Test -
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المؤلفون: Olivia Chapuis, Pierre Kubicek, Aude Fléchon, Cécile Faure-Conter, Julien Jacquemus, Tanguy Fenouil, Cécile Dumesnil
المصدر: Cancer Investigation. :1-7
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, endocrine system, Cancer Research, Extragonadal, Adolescent, Biology, Mediastinal Neoplasms, Young Adult, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Germinoma, urogenital system, Embryogenesis, Disease Management, Neoplasms, Second Primary, General Medicine, Neoplasms, Germ Cell and Embryonal, medicine.disease, Combined Modality Therapy, Seminoma, Checkpoint Kinase 2, Transformation (genetics), 030104 developmental biology, Oncology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, Germ cell tumors, MutL Protein Homolog 1, Pinealoma
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8056e3f3ab5f40b6e331384c3be93eeaTest
https://doi.org/10.1080/07357907.2020.1828447Test -
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المؤلفون: Lulu Wang, Clemens An, Gordon B. Mills, Xuetong Shen, Yen T. Luu, Wei Zhao, Shumei Song, Lin Yang, Zhenlin Ju, Chen Wang, Wei Zhang, Jianfeng Shen, Timothy A. Yap, Yang Peng, Guang Peng, Jaffer A. Ajani
المصدر: J Clin Invest
مصطلحات موضوعية: 0301 basic medicine, ARID1A, medicine.medical_treatment, Ataxia Telangiectasia Mutated Proteins, Mice, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, Cancer immunotherapy, Neoplasms, medicine, Animals, Humans, Innate immune system, biology, Chemistry, Kinase, Membrane Proteins, General Medicine, G2-M DNA damage checkpoint, HCT116 Cells, Nucleotidyltransferases, Immune checkpoint, Neoplasm Proteins, Blockade, DNA-Binding Proteins, Checkpoint Kinase 2, enzymes and coenzymes (carbohydrates), 030104 developmental biology, 030220 oncology & carcinogenesis, Proteolysis, biology.protein, Cancer research, biological phenomena, cell phenomena, and immunity, Signal Transduction, Transcription Factors, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1def25b761f2a0b0c109422b2a11c2Test
https://doi.org/10.1172/jci130445Test