نتائج البحث - "Ubiquitin-Protein Ligase"

المساهمون: Schiattarella, G. G., Altamirano, F., Kim, S. Y., Tong, D., Ferdous, A., Piristine, H., Dasgupta, S., Wang, X., French, K. M., Villalobos, E., Spurgin, S. B., Waldman, M., Jiang, N., May, H. I., Hill, T. M., Luo, Y., Yoo, H., Zaha, V. G., Lavandero, S., Gillette, T. G., Hill, J. A.

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, X-Box Binding Protein 1, Ubiquitin-Protein Ligase, Transcription, Genetic, General Physics and Astronomy, FOXO1, 030204 cardiovascular system & hematology, Heart Ventricle, Mice, 0302 clinical medicine, Ubiquitin, HEK293 Cell, Myocytes, Cardiac, Proteolysi, Conserved Sequence, Multidisciplinary, biology, Chemistry, Forkhead Box Protein O1, Protein Stability, Cell biology, Ubiquitin ligase, Phenotype, Cell signalling, Human, Heart Ventricles, Ubiquitin-Protein Ligases, Science, Models, Biological, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, medicine, Animals, Humans, Transcription factor, STUB1, Heart Failure, Binding Sites, Base Sequence, Animal, Myocardium, Binding Site, Stroke Volume, General Chemistry, medicine.disease, Lipid Metabolism, Myocardial Contraction, Mice, Inbred C57BL, HEK293 Cells, 030104 developmental biology, Cardiovascular and Metabolic Diseases, Heart failure, Proteolysis, biology.protein, Unfolded protein response, Heart failure with preserved ejection fraction, Gene Deletion

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b81c76663dfe090feb3e2f4b003006Test
https://doaj.org/article/5e96ad72a7fc4e428e30cd13deb2825bTest

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Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers

المؤلفون: Liang Ouyang, Yao Liu, Jie Liu, Lu Feng, Guan Wang, Yi Chen, Meng Wang, Tingting Jiang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 355-372 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: NTRK, neurotrophic receptor tyrosine kinase, FISH, fluorescence in situ hybridization, Review, Tropomyosin receptor kinase B, HNSCC, head and neck squamous cell carcinoma, Tropomyosin receptor kinase A, HTS, high-throughput screening, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase, Tropomyosin receptor kinase C, LMNA, lamin A/C, Receptor tyrosine kinase, TPM3, tropomyosin 3, 0302 clinical medicine, MASC, mammary analogue secretory carcinoma, PROTAC proteolysis targeting chimera, QKI, SQSTM1, sequestosome 1, TPR, translocated promoter region, General Pharmacology, Toxicology and Pharmaceutics, RABGTPase activating protein 1-like, RFWD2, AML, acute myeloid leukemia, 0303 health sciences, ICC, intrahepatic cholangiocarcinoma, TRK, tropomyosin receptor kinase, Neurotrophic receptor tyrosine kinase fusions, PPL, periplakin, TP53, tumor protein P53, SBC, secretory breast carcinoma, OAK, osteoarthritis of the knee, TFG, TRK-fused gene, ARHGEF2, Rho/Rac guanine nucleotide exchange factor 2, NT3, neurotrophin-3, quaking I protein, RABGAP1L, ETV6, ETS translocation variant 6, 030220 oncology & carcinogenesis, CR, complete response, CRC, colorectal cancer, BCAN, brevican, BDNF, brain-derived neurotrophic factor, BTBD1, BTB (POZ) domain containing 1, RTK, receptor tyrosine kinase, DOR, durable objective responses, CDK-2, cyclin-dependent kinase 2, Tyrosine kinase, EWG, electron-withdrawing group, ORR, overall response rate, Neurotrophin, NCCN, National Comprehensive Cancer Network, VCL, vinculin, NGF, nerve growth factor, MPRIP, myosin phosphatase Rho interacting protein, Biology, PAN3, poly(A) nuclease 3, TRIM24, tripartite motif containing 24, Small-molecule inhibitor, NTRK fusion cancer, SCYL3, SCY1 like pseudokinase 3, 03 medical and health sciences, NACC2, NACC family member 2, NSCLC, non-small cell lung cancer, SAR, structure–activity relationship, Protein kinase B, VEGFR2, vascular endothelial growth factor receptor 2, 030304 developmental biology, DFG, Asp-Phe-Gly, CTCs, sequencing of circulating tumor cells, lcsh:RM1-950, GBM, glioblastoma multiforme, NFASC, neurofascin, NGS, next-generation sequencing of tumor tissue, FDA, U.S. Food and Drug Administration, lcsh:Therapeutics. Pharmacology, nervous system, Trk receptor, IG-C2, Ig-like C2 type I, Cancer research, biology.protein, Tropomyosin receptor kinase, AFAP1, actin filament-associated protein 1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c737a8f0c0bb6776695689290564cb8aTest
http://www.sciencedirect.com/science/article/pii/S2211383520305864Test

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Phosphorylation regulates cullin-based ubiquitination in tumorigenesis

المؤلفون: Meidan Ying, Xuejing Shao, Hong Zhu, Ji Cao, Bo Yang, Yifan Chen, Qiaojun He

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 309-321 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: SRC-3, nuclear receptor coactivator 3, VHL, von Hippel-Lindau tumor suppressor, RRM2, ribonucleotide reductase regulatory subunit M2, KRAS, KRAS proto-oncogene, GTPase, SNAIL1, snail family transcriptional repressor 1, medicine.medical_treatment, CRL, cullin-RING ligase, ERK, mitogen-activated protein kinase 1, NEDD8, NEDD8 ubiquitin like modifier, Review, medicine.disease_cause, JAB1, c-Jun activation domain binding protein-1, p130Cas, BCAR1 scaffold protein, Cas family member, law.invention, Targeted therapy, Degradation, 0302 clinical medicine, Ubiquitin, law, RA, retinoic acid, FBXL3, F-box and leucine rich repeat protein, Ci, cubitus interruptus, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Crosstalk, FBXO3/31, F-box protein 3/31, 0303 health sciences, biology, KEAP1, kelch like ECH associated protein 1, Kinase, Chemistry, KBTBD8, kelch repeat and BTB domain containing 8, CSN, COP9 signalosome, DYRK1A/B, dual-specificity tyrosine-phosphorylation-regulated kinases 1A/B, FBW7, F-box and WD repeat domain containing 7, CDT2, denticleless E3 ubiquitin protein ligase homolog, NRF2, nuclear factor, erythroid 2 like 2, TCN, triciribine hydrate, Cell biology, USP37, ubiquitin specific peptidase 37, Crosstalk (biology), XBP1, X-box binding protein 1, 030220 oncology & carcinogenesis, HCC, hepatocellular carcinomas, Vps34, phosphatidylinositol 3-kinase catalytic subunit type 3, CK1/2, casein kinase I/II, COMMD1, copper metabolism domain containing 1, KLHL3, kelch like family member 3, EMT, epithelial–mesenchymal transition, Cullin, P-TEFb, positive transcription elongation factor b, CDK2/4, cyclin dependent kinase 2/4, SPOP, speckle-type POZ protein, AIRE, autoimmune regulator, PYGO2, pygopus 2, TCOF1, treacle ribosome biogenesis factor 1, ID2, inhibitor of DNA binding 2, CHK1, checkpoint kinase 1, Kinases, FZR1, fizzy and cell division cycle 20 related 1, HIF1α, NF-κB and hypoxia inducible factor 1 subunit alpha, EXO1, exonuclease 1, ZBTB16, zinc finger and BTB domain containing 16, NOLC1, nucleolar and coiled-body phosphoprotein 1, 03 medical and health sciences, PKM2, pyruvate kinase M2 isoform, KDM2B, lysine demethylase 2B, PKC, protein kinase C, Cullin-RING ligases, medicine, BMAL1, aryl hydrocarbon receptor nuclear translocator like, ATR, ataxia telangiectasia-mutated and Rad3-related, SOCS6, suppressor of cytokine signaling 6, 030304 developmental biology, PDL1, programmed death ligand 1, HIB, Hedghog-induced MATH and BTB domain-containing protein, AKT, AKT serine/threonine kinase, lcsh:RM1-950, Ubiquitination, TRF1, telomeric repeat binding factor 1, DDB1, damage specific DNA binding protein 1, BCL2, BCL2 apoptosis regulator, CLOCK, clock circadian regulator, MYC, MYC proto-oncogene, bHLH transcription factor, lcsh:Therapeutics. Pharmacology, c-Fos, Fos proto-oncogene, AP-1 transcription factor subunit, RARα, RA receptor α, Tumorigenesis, biology.protein, Suppressor, CRY1, cryptochrome circadian regulator 1, ERG, ETS transcription factor ERG, Carcinogenesis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27b7f488f3a53677836e1b8e5b2722dTest
https://doi.org/10.1016/j.apsb.2020.09.007Test

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A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters

المؤلفون: Brenda A. Schulman, Viola Beier, Jakub Chrustowicz, Matthias Mann, Ozge Karayel, Dawafuti Sherpa, Christine R. Langlois

المصدر: EMBO reports. 23(6)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24946acbe0815ef67a0508a1ba6bad30Test
https://pubmed.ncbi.nlm.nih.gov/35437932Test

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Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

المؤلفون: Edward Chung Yern Wang, Luis Nobre, Martin Potts, Alice Fletcher-Etherington, Katie Nightingale, Zerbe C, Nicolás M. Suárez, Jenna Nichols, Robin Antrobus, Andrew J. Davison, Jack W. Houghton, Leah M. Hunter, Michael P. Weekes, Richard J. Stanton, Ceri Alan Fielding, Blair L. Strang

المساهمون: Nightingale, Katie [0000-0001-9958-4699], Potts, Martin [0000-0002-6738-0066], Hunter, Leah M [0000-0002-0000-5712], Fletcher-Etherington, Alice [0000-0001-7313-9247], Nobre, Luis [0000-0003-0467-8989], Wang, Eddie CY [0000-0002-2243-4964], Strang, Blair L [0000-0001-9407-1974], Suarez, Nicolas M [0000-0001-8429-8374], Nichols, Jenna [0000-0003-0093-7170], Davison, Andrew J [0000-0002-4991-9128], Stanton, Richard J [0000-0002-6799-1182], Weekes, Michael [0000-0003-3196-5545], Apollo - University of Cambridge Repository, Weekes, Michael P [0000-0003-3196-5545]

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb899ad069b60b78c6c6a6ccf4270619Test
https://www.repository.cam.ac.uk/handle/1810/331636Test

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