التفاصيل البيبلوغرافية
| العنوان: |
Lipids and membrane-associated proteins in autophagy. |
| المؤلفون: |
Li, Linsen, Tong, Mindan, Fu, Yuhui, Chen, Fang, Zhang, Shen, Chen, Hanmo, Ma, Xi, Li, Defa, Liu, Xiaoxia, Zhong, Qing |
| المصدر: |
Protein & Cell; Jul2021, Vol. 12 Issue 7, p520-544, 25p |
| مستخلص: |
Autophagy is essential for the maintenance of cellular homeostasis and its dysfunction has been linked to various diseases. Autophagy is a membrane driven process and tightly regulated by membrane-associated proteins. Here, we summarized membrane lipid composition, and membrane-associated proteins relevant to autophagy from a spatiotemporal perspective. In particular, we focused on three important membrane remodeling processes in autophagy, lipid transfer for phagophore elongation, membrane scission for phagophore closure, and autophagosome-lysosome membrane fusion. We discussed the significance of the discoveries in this field and possible avenues to follow for future studies. Finally, we summarized the membrane-associated biochemical techniques and assays used to study membrane properties, with a discussion of their applications in autophagy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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