يعرض 1 - 10 نتائج من 20 نتيجة بحث عن '"Patrick J. Bednarski"', وقت الاستعلام: 1.40s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Comparison of Cellular Death Pathways after mTHPC-mediated Photodynamic Therapy (PDT) in Five Human Cancer Cell Lines

    المؤلفون: Carsten Lange, Christiane Lehmann, Martin Mahler, Patrick J. Bednarski

    المصدر: Cancers, Vol 11, Iss 5, p 702 (2019)

    مصطلحات موضوعية: mTHPC, photodynamic therapy, oxidative stress, necrosis, apoptosis, autophagy, cell cycle, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

    وصف الملف: electronic resource

    العلاقة: https://www.mdpi.com/2072-6694/11/5/702Test; https://doaj.org/toc/2072-6694Test

    الوصول الحر: https://doaj.org/article/1e909a4f47234566b65a33b305d38ed7Test

    View record in DOAJ النص الكامل

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  2. 2
    Comprehensive Evaluation of Biological Effects of Pentathiepins on Various Human Cancer Cell Lines and Insights into Their Mode of Action

    المؤلفون: Lisa Wolff, Siva Sankar Murthy Bandaru, Elias Eger, Hoai-Nhi Lam, Martin Napierkowski, Daniel Baecker, Carola Schulzke, Patrick J. Bednarski

    المصدر: International Journal of Molecular Sciences
    Volume 22
    Issue 14
    International Journal of Molecular Sciences, Vol 22, Iss 7631, p 7631 (2021)

    مصطلحات موضوعية: reactive oxygen species, pentathiepin, Molecular Structure, QH301-705.5, Antineoplastic Agents, Apoptosis, Glutathione, Article, Chemistry, Oxidative Stress, Structure-Activity Relationship, Glutathione Peroxidase GPX1, Cell Line, Tumor, sulfur, cancer cells, Humans, cytotoxicity, DNA damage, Biology (General), Thiepins, glutathione peroxidase, QD1-999, Cell Proliferation

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a7d2a658a7aaf555df3e4e6858275624Test


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  3. 3
    Synthesis, Structure and Cytotoxicity Testing of Novel 7-(4,5-dihydro-1H-imidazol-2-yl)-2-aryl-6,7-dihydro-2H-imidazo[2,1-c][1,2,4]triazol-3(5H)-Imine Derivatives

    المؤلفون: Łukasz Balewski, Anita Kornicka, Anna Nadworska, Maria Gdaniec, Franciszek Sączewski, Patrick J. Bednarski, Lisa Wolff

    المصدر: Molecules
    Volume 25
    Issue 24
    Molecules, Vol 25, Iss 5924, p 5924 (2020)

    مصطلحات موضوعية: Stereochemistry, Imine, Pharmaceutical Science, 01 natural sciences, Analytical Chemistry, lcsh:QD241-441, chemistry.chemical_compound, lcsh:Organic chemistry, sulfonamides, Drug Discovery, Physical and Theoretical Chemistry, Benzamide, Biphenyl, in vitro cytotoxic activity, 010405 organic chemistry, Aryl, ureas, Organic Chemistry, In vitro, 0104 chemical sciences, amides, 010404 medicinal & biomolecular chemistry, imidazo[2,1-c][1,2,4]triazol-3(5H)-imines, chemistry, Chemistry (miscellaneous), Cell culture, Apoptosis, Molecular Medicine, thioureas, Selectivity, X-ray analysis

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d739bfce732b4be04136c02fd325942Test


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  4. 4
    In vitro assessment of synergistic effects in combinations of a temoporfin-based photodynamic therapy with glutathione peroxidase 1 inhibitors

    المؤلفون: Carsten Lange, Patrick J. Bednarski

    المصدر: Photodiagnosis and Photodynamic Therapy. 36:102478

    مصطلحات موضوعية: GPX1, medicine.medical_treatment, Biophysics, Apoptosis, Photodynamic therapy, Dermatology, medicine.disease_cause, Temoporfin, chemistry.chemical_compound, Glutathione Peroxidase GPX1, Cell Line, Tumor, medicine, Humans, Pharmacology (medical), chemistry.chemical_classification, Glutathione Peroxidase, Reactive oxygen species, Photosensitizing Agents, Hydrogen Peroxide, Cell cycle, Mesoporphyrins, Photochemotherapy, Oncology, chemistry, Cancer cell, Cancer research, Reactive Oxygen Species, Oxidative stress

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85705d57cba3271f9b2aa1fdd04088f8Test
    https://doi.org/10.1016Test/j.pdpdt.2021.102478


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  5. 5
    Pentathiepins: A Novel Class of Glutathione Peroxidase 1 Inhibitors that Induce Oxidative Stress, Loss of Mitochondrial Membrane Potential and Apoptosis in Human Cancer Cells

    المؤلفون: Martin Napierkowski, Lisa Wolff, Siva Sankar Murthy Bandaru, Claudia Urbainsky, Steven Behnisch‐Cornwell, Carola Schulzke, Christopher Horst Lillig, Muhammad Zubair, Patrick J. Bednarski

    المصدر: Chemmedchem

    مصطلحات موضوعية: GPX1, Thioredoxin reductase, Glutathione reductase, DNA fragmentation, Apoptosis, medicine.disease_cause, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Glutathione Peroxidase GPX1, Heterocyclic Compounds, Drug Discovery, Tumor Cells, Cultured, General Pharmacology, Toxicology and Pharmaceutics, Enzyme Inhibitors, chemistry.chemical_classification, Membrane Potential, Mitochondrial, biology, Full Paper, Molecular Structure, Chemistry, Glutathione peroxidase, Full Papers, Molecular Medicine, cytotoxicity, Cell Survival, Antineoplastic Agents, Sulfides, Superoxide dismutase, Structure-Activity Relationship, Very Important Paper, medicine, Humans, Cell Proliferation, Pharmacology, Reactive oxygen species, Glutathione Peroxidase, pentathiepin, Dose-Response Relationship, Drug, 010405 organic chemistry, Organic Chemistry, Glutathione, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Oxidative Stress, biology.protein, cancer cells, Drug Screening Assays, Antitumor, Oxidative stress

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccc766db533f3ed3c5850477407fbc9Test
    https://pubmed.ncbi.nlm.nih.gov/32311219Test


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  6. 6
    In vitro evaluation of the enantiomeric R- and S-1,1′-binaphthyl-2,2′-diaminodichlorido–Pt(ii) complexes in human Burkitt lymphoma cells: emphasis on cellular accumulation, cytotoxicity, DNA binding, and ability to induce apoptosis

    المؤلفون: Ian Henry Lambert, Patrick Werth, Belinda Halling Sørensen, Patrick J. Bednarski

    المصدر: Metallomics. 10:323-336

    مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, Stereochemistry, Biophysics, Antineoplastic Agents, Apoptosis, In Vitro Techniques, Naphthalenes, Biochemistry, Biomaterials, 03 medical and health sciences, 0302 clinical medicine, Coordination Complexes, Tumor Cells, Cultured, medicine, Humans, Cytotoxic T cell, Cytotoxicity, Cell Proliferation, Platinum, Cisplatin, Molecular Structure, Chemistry, Cell Cycle, Metals and Alloys, Stereoisomerism, DNA, Burkitt Lymphoma, In vitro, 030104 developmental biology, Drug Resistance, Neoplasm, Chemistry (miscellaneous), Cell culture, 030220 oncology & carcinogenesis, G1 phase, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ba5b16cf2f58b1fcf4cca5fdbadd65Test
    https://doi.org/10.1039/c7mt00237hTest


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  7. 7
    Evaluation for Synergistic Effects by Combinations of Photodynamic Therapy (PDT) with Temoporfin (mTHPC) and Pt(II) Complexes Carboplatin, Cisplatin or Oxaliplatin in a Set of Five Human Cancer Cell Lines

    المؤلفون: Patrick J. Bednarski, Carsten Lange

    المصدر: International Journal of Molecular Sciences
    International Journal of Molecular Sciences, Vol 19, Iss 10, p 3183 (2018)
    Volume 19
    Issue 10

    مصطلحات موضوعية: 0301 basic medicine, combination assay, medicine.medical_treatment, cisplatin, Photodynamic therapy, Apoptosis, Carboplatin, lcsh:Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Cytotoxicity, lcsh:QH301-705.5, Spectroscopy, Drug Synergism, General Medicine, Computer Science Applications, photodynamic therapy, Mesoporphyrins, 030220 oncology & carcinogenesis, cancer therapy, medicine.drug, Cell Survival, DNA Fragmentation, Phosphatidylserines, Catalysis, Article, Exocytosis, Inorganic Chemistry, Temoporfin, 03 medical and health sciences, Inhibitory Concentration 50, synergism, Cell Line, Tumor, medicine, Humans, MTT assay, Physical and Theoretical Chemistry, Molecular Biology, Cisplatin, Organic Chemistry, oxaliplatin, Cancer, Cell Cycle Checkpoints, medicine.disease, Oxaliplatin, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, chemistry, Photochemotherapy, Cancer research, Reactive Oxygen Species, mTHPC, Pt(II) complexes

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a75c2572265281add91180b900fe22Test
    http://europepmc.org/articles/PMC6214074Test


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  8. 8
    Front Cover: Pentathiepins: A Novel Class of Glutathione Peroxidase 1 Inhibitors that Induce Oxidative Stress, Loss of Mitochondrial Membrane Potential and Apoptosis in Human Cancer Cells (ChemMedChem 16/2020)

    المؤلفون: Siva Sankar Murthy Bandaru, Christopher Horst Lillig, Patrick J. Bednarski, Muhammad Zubair, Steven Behnisch‐Cornwell, Carola Schulzke, Claudia Urbainsky, Martin Napierkowski, Lisa Wolff

    المصدر: ChemMedChem. 15:1497-1497

    مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Membrane potential, GPX1, Glutathione peroxidase, Organic Chemistry, medicine.disease_cause, Biochemistry, Cell biology, chemistry, Apoptosis, Drug Discovery, Cancer cell, medicine, Molecular Medicine, DNA fragmentation, General Pharmacology, Toxicology and Pharmaceutics, Cytotoxicity, Oxidative stress

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::25a192debb204c604460d447d10687d3Test
    https://doi.org/10.1002/cmdc.202000577Test


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  9. 9
    Synthesis, Pharmacological Evaluation, and σ1 Receptor Interaction Analysis of Hydroxyethyl Substituted Piperazines

    المؤلفون: Katharina Korpis, Valentina Dal Col, Patrick J. Bednarski, Stefanie Brune, Dirk Schepmann, Bernhard Wünsch, Frauke Weber, Sabrina Pricl, Erik Laurini

    المساهمون: Frauke, Weber, Steffi, Brune, Katharina, Korpi, Patrick J., Bednarski, Laurini, Erik, DAL COL, Valentina, Pricl, Sabrina, Dirk, Schepmann, Bernhard, Wünsch

    المصدر: Journal of Medicinal Chemistry. 57:2884-2894

    مصطلحات موضوعية: Models, Molecular, Stereochemistry, Guinea Pigs, sigma receptors, computer assisted drug design, Antineoplastic Agents, Apoptosis, Plasma protein binding, Molecular Dynamics Simulation, Piperazines, Structure-Activity Relationship, Neoplasms, Drug Discovery, Tumor Cells, Cultured, Animals, Humans, Receptors, sigma, Structure–activity relationship, Homology modeling, sigma receptor, Receptor, Molecular Structure, Chemistry, Brain, Ligand (biochemistry), Affinities, Cell culture, Molecular Medicine, Chromatography, Thin Layer, Protein Binding

    وصف الملف: STAMPA

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de21ded4a7d95a96339e4c5711ed5b77Test
    https://doi.org/10.1021/jm401707tTest


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  10. 10
    Rigidity versus Flexibility: Is This an Issue in σ1 Receptor Ligand Affinity and Activity?

    المؤلفون: Carsten Lange, Frauke Weber, Patrick J. Bednarski, Maurizio Fermeglia, Bernhard Wünsch, Dirk Schepmann, Frederik Börgel, Stefanie Brune, Erik Laurini, Sabrina Pricl, Katharina Korpis

    المصدر: Journal of Medicinal Chemistry. 59:5505-5519

    مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Stereochemistry, Guinea Pigs, Antineoplastic Agents, Apoptosis, Ligands, Heterocyclic Compounds, 2-Ring, Piperazines, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Receptors, sigma, Structure–activity relationship, Receptor, Cell Proliferation, Sigma-1 receptor, Dose-Response Relationship, Drug, Molecular Structure, Bicyclic molecule, Cell growth, Chemistry, Ligand, Biological activity, 030104 developmental biology, Mechanism of action, 030220 oncology & carcinogenesis, Thermodynamics, Molecular Medicine, Drug Screening Assays, Antitumor, medicine.symptom

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf03d726ba597ffbd869cae9faec2cbTest
    https://doi.org/10.1021/acs.jmedchem.6b00585Test


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