دورية أكاديمية
Requirement for Pak3 in Rac1-induced organization of actin and myosin during Drosophila larval wound healing.
| العنوان: | Requirement for Pak3 in Rac1-induced organization of actin and myosin during Drosophila larval wound healing. |
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| المساهمون: | Seung Hee Baek, Hae Weon Cho, Young-Chang Kwon, Ji Hyun Lee, Moon Jong Kim, Hyangkyu Lee, Kwang-Min Choe, Lee, Hyang Kyu |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Actins/metabolism, Animals, Drosophila Proteins/metabolism, Drosophila melanogaster/physiology, Epidermis/pathology, Epidermis/physiology, Larva/anatomy & histology, Larva/physiology, Myosins/metabolism, Recombinant Fusion Proteins/genetics, Recombinant Fusion Proteins/metabolism, Wound Healing/physiology, p21-Activated Kinases/genetics, p21-Activated Kinases/metabolism, rac1 GTP-Binding Protein/genetics, rac1 GTP-Binding Protein/metabolism, Wound repair, Cell migration, Chemotaxis, Cell polarization, Actin cable |
| الوصف: | Rho-family small GTPases regulate epithelial cell sheet migration by organizing actin and myosin during wound healing. Here, we report that Pak3, but not Pak1, is a downstream target protein for Rac1 in wound closure of the Drosophila larval epidermis. Pak3-deficient larvae failed to close a wound hole and this defect was not rescued by Pak1 expression, indicating differential functions of the two proteins. Pak3 localized to the wound margin, which selectively required Rac1. Pak3-deficient larvae showed severe defects in actin-myosin organization at the wound margin and in submarginal cells, which was reminiscent of the phenotypes of Rac1-deficient larvae. These results suggest that Pak3 specifically mediates Rac1 signaling in organizing actin and myosin during Drosophila epidermal wound healing. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0014-5793 1873-3468 |
| العلاقة: | FEBS LETTERS; J00890; OAK-2012-00205; https://ir.ymlib.yonsei.ac.kr/handle/22282913/90291Test; http://www.sciencedirect.com/science/article/pii/S001457931200110XTest; T201200423; FEBS LETTERS, Vol.586(6) : 772-777, 2012 |
| الإتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90291Test http://www.sciencedirect.com/science/article/pii/S001457931200110XTest |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.6DD825BB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00145793 18733468 |
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