المؤلفون: Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Target, ONRs, orphan nuclear receptors, Parkinson's disease, Small-molecule compound, MPP+, 1-methyl-4-phenylpyridinium, Autolysosome, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, GBA, glucocerebrosidase β acid, Review, MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, Disease, mTORC1, mTOR, the mammalian target of rapamycin, PD, Parkinson's disease, 0302 clinical medicine, CL, clearance rate, DAT, dopamine transporter, HDAC6, histone deacetylase 6, PD therapy, A2A, adenosine 2A, MYCBP2, MYC-binding protein 2, TFEB, transcription factor EB, AUTAC, autophagy targeting chimera, General Pharmacology, Toxicology and Pharmaceutics, SAS, solvent accessible surface, 0303 health sciences, α-syn, α-synuclein, ALP, autophagy-lysosomal pathway, AADC, aromatic amino acid decarboxylase, DJ-1, Parkinson protein 7, PI3K, phosphatidylinositol 3-kinase, COMT, catechol-O-methyltransferase, LUHMES, lund human mesencephalic, LRRK2, CMA, chaperone-mediated autophagy, KI, knockin, 030220 oncology & carcinogenesis, LRS, leucyl-tRNA synthetase, BBB, blood−brain barrier, SN, substantia nigra, IMPase, inositol monophosphatase, IPPase, inositol polyphosphate 1-phosphatase, HSPA8, heat shock 70 kDa protein 8, MAO-B, monoamine oxidase B, PREP, prolyl oligopeptidase, Parkinson's disease (PD), DR, dopamine receptor, PDE4, phosphodiesterase 4, AMPK, 5ʹAMP-activated protein kinase, 5-HT2C, serotonin 2C, SNCA, α-synuclein gene, TSC2, tuberous sclerosis complex 2, RM1-950, LIMP-2, lysosomal integrated membrane protein-2, CNS, central nervous system, 5-HT2A, Serotonin 2A, ER, endoplasmic reticulum, ATG, autophagy related protein, 03 medical and health sciences, PLC, phospholipase C, ROS, reactive oxygen species, ERRα, estrogen-related receptor alpha, SAR, structure–activity relationship, ULK1, UNC-51-like kinase 1, medicine, Autophagy, NMDA, N-methyl-d-aspartic acid, mAChR, muscarinic acetylcholine receptor, GWAS, genome-wide association study, LAMP2A, lysosome-associated membrane protein 2 A, Lamp2a, type 2A lysosomal-associated membrane protein, 030304 developmental biology, Parkin, parkin RBR E3 ubiquitin−protein ligase, PINK1, PTEN-induced kinase 1, ATTEC, autophagosome-tethering compound, ATP13A2, ATPase cation transporting 13A2, business.industry, ULK1, medicine.disease, LC3, light chain 3, PI3P, phosphatidylinositol 3-phosphate, SYT11, synaptotagmin 11, AUC, the area under the curve, UPS, ubiquitin−proteasome system, TFEB, DA, dopamine, Therapeutics. Pharmacology, business, BAF, bafilomycinA1, HSC70, heat shock cognate 71 kDa protein, Neuroscience, 3-MA, 3-methyladenine, F, oral bioavailability, LRRK2, leucine-rich repeat sequence kinase 2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12dab43aca56bfd6a912c2aa71297ffTest
http://www.sciencedirect.com/science/article/pii/S2211383521000642Test

المؤلفون: Ayberk Türkyılmaz, Huseyin Demirbilek, Emine Kartal Baykan, Oguzhan Yarali, Erdal Kurnaz, Atilla Cayir, Esra Arslan Ates

المصدر: Journal of Pediatric Endocrinology and Metabolism. 34:771-780

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Genetic counseling, 030209 endocrinology & metabolism, Genetic analysis, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Hypergonadotropic hypogonadism, Hypogonadotropic hypogonadism, Internal medicine, medicine, Humans, Receptor, Fibroblast Growth Factor, Type 1, Exome sequencing, Retrospective Studies, Genetic heterogeneity, business.industry, Hypogonadism, Nuclear Proteins, Ubiquitin-Protein Ligase Complexes, Oligogenic Inheritance, Prognosis, medicine.disease, Penetrance, 030104 developmental biology, Mutation, Pediatrics, Perinatology and Child Health, Female, business, Biomarkers, Follow-Up Studies, Receptors, Kisspeptin-1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9d477bdb5ec24154d242c5b5bc8565Test
https://doi.org/10.1515/jpem-2020-0590Test

المؤلفون: Joseph A. Hill, Xuliang Wang, Nan Jiang, Soo Young Kim, Stephen B. Spurgin, Hande Piristine, Sergio Lavandero, Kristin M. French, Vlad G. Zaha, Francisco Altamirano, Subhajit Dasgupta, Anwarul Ferdous, Theodore M. Hill, Herman I. May, Thomas G. Gillette, Maayan Waldman, Dan Tong, Gabriele G. Schiattarella, Heesoo Yoo, Yuxuan Luo, Elisa Villalobos

المساهمون: Schiattarella, G. G., Altamirano, F., Kim, S. Y., Tong, D., Ferdous, A., Piristine, H., Dasgupta, S., Wang, X., French, K. M., Villalobos, E., Spurgin, S. B., Waldman, M., Jiang, N., May, H. I., Hill, T. M., Luo, Y., Yoo, H., Zaha, V. G., Lavandero, S., Gillette, T. G., Hill, J. A.

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, X-Box Binding Protein 1, Ubiquitin-Protein Ligase, Transcription, Genetic, General Physics and Astronomy, FOXO1, 030204 cardiovascular system & hematology, Heart Ventricle, Mice, 0302 clinical medicine, Ubiquitin, HEK293 Cell, Myocytes, Cardiac, Proteolysi, Conserved Sequence, Multidisciplinary, biology, Chemistry, Forkhead Box Protein O1, Protein Stability, Cell biology, Ubiquitin ligase, Phenotype, Cell signalling, Human, Heart Ventricles, Ubiquitin-Protein Ligases, Science, Models, Biological, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, medicine, Animals, Humans, Transcription factor, STUB1, Heart Failure, Binding Sites, Base Sequence, Animal, Myocardium, Binding Site, Stroke Volume, General Chemistry, medicine.disease, Lipid Metabolism, Myocardial Contraction, Mice, Inbred C57BL, HEK293 Cells, 030104 developmental biology, Cardiovascular and Metabolic Diseases, Heart failure, Proteolysis, biology.protein, Unfolded protein response, Heart failure with preserved ejection fraction, Gene Deletion

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b81c76663dfe090feb3e2f4b003006Test
https://doaj.org/article/5e96ad72a7fc4e428e30cd13deb2825bTest

المؤلفون: Liang Ouyang, Yao Liu, Jie Liu, Lu Feng, Guan Wang, Yi Chen, Meng Wang, Tingting Jiang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 355-372 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: NTRK, neurotrophic receptor tyrosine kinase, FISH, fluorescence in situ hybridization, Review, Tropomyosin receptor kinase B, HNSCC, head and neck squamous cell carcinoma, Tropomyosin receptor kinase A, HTS, high-throughput screening, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase, Tropomyosin receptor kinase C, LMNA, lamin A/C, Receptor tyrosine kinase, TPM3, tropomyosin 3, 0302 clinical medicine, MASC, mammary analogue secretory carcinoma, PROTAC proteolysis targeting chimera, QKI, SQSTM1, sequestosome 1, TPR, translocated promoter region, General Pharmacology, Toxicology and Pharmaceutics, RABGTPase activating protein 1-like, RFWD2, AML, acute myeloid leukemia, 0303 health sciences, ICC, intrahepatic cholangiocarcinoma, TRK, tropomyosin receptor kinase, Neurotrophic receptor tyrosine kinase fusions, PPL, periplakin, TP53, tumor protein P53, SBC, secretory breast carcinoma, OAK, osteoarthritis of the knee, TFG, TRK-fused gene, ARHGEF2, Rho/Rac guanine nucleotide exchange factor 2, NT3, neurotrophin-3, quaking I protein, RABGAP1L, ETV6, ETS translocation variant 6, 030220 oncology & carcinogenesis, CR, complete response, CRC, colorectal cancer, BCAN, brevican, BDNF, brain-derived neurotrophic factor, BTBD1, BTB (POZ) domain containing 1, RTK, receptor tyrosine kinase, DOR, durable objective responses, CDK-2, cyclin-dependent kinase 2, Tyrosine kinase, EWG, electron-withdrawing group, ORR, overall response rate, Neurotrophin, NCCN, National Comprehensive Cancer Network, VCL, vinculin, NGF, nerve growth factor, MPRIP, myosin phosphatase Rho interacting protein, Biology, PAN3, poly(A) nuclease 3, TRIM24, tripartite motif containing 24, Small-molecule inhibitor, NTRK fusion cancer, SCYL3, SCY1 like pseudokinase 3, 03 medical and health sciences, NACC2, NACC family member 2, NSCLC, non-small cell lung cancer, SAR, structure–activity relationship, Protein kinase B, VEGFR2, vascular endothelial growth factor receptor 2, 030304 developmental biology, DFG, Asp-Phe-Gly, CTCs, sequencing of circulating tumor cells, lcsh:RM1-950, GBM, glioblastoma multiforme, NFASC, neurofascin, NGS, next-generation sequencing of tumor tissue, FDA, U.S. Food and Drug Administration, lcsh:Therapeutics. Pharmacology, nervous system, Trk receptor, IG-C2, Ig-like C2 type I, Cancer research, biology.protein, Tropomyosin receptor kinase, AFAP1, actin filament-associated protein 1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c737a8f0c0bb6776695689290564cb8aTest
http://www.sciencedirect.com/science/article/pii/S2211383520305864Test

المؤلفون: Meidan Ying, Xuejing Shao, Hong Zhu, Ji Cao, Bo Yang, Yifan Chen, Qiaojun He

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 309-321 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: SRC-3, nuclear receptor coactivator 3, VHL, von Hippel-Lindau tumor suppressor, RRM2, ribonucleotide reductase regulatory subunit M2, KRAS, KRAS proto-oncogene, GTPase, SNAIL1, snail family transcriptional repressor 1, medicine.medical_treatment, CRL, cullin-RING ligase, ERK, mitogen-activated protein kinase 1, NEDD8, NEDD8 ubiquitin like modifier, Review, medicine.disease_cause, JAB1, c-Jun activation domain binding protein-1, p130Cas, BCAR1 scaffold protein, Cas family member, law.invention, Targeted therapy, Degradation, 0302 clinical medicine, Ubiquitin, law, RA, retinoic acid, FBXL3, F-box and leucine rich repeat protein, Ci, cubitus interruptus, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Crosstalk, FBXO3/31, F-box protein 3/31, 0303 health sciences, biology, KEAP1, kelch like ECH associated protein 1, Kinase, Chemistry, KBTBD8, kelch repeat and BTB domain containing 8, CSN, COP9 signalosome, DYRK1A/B, dual-specificity tyrosine-phosphorylation-regulated kinases 1A/B, FBW7, F-box and WD repeat domain containing 7, CDT2, denticleless E3 ubiquitin protein ligase homolog, NRF2, nuclear factor, erythroid 2 like 2, TCN, triciribine hydrate, Cell biology, USP37, ubiquitin specific peptidase 37, Crosstalk (biology), XBP1, X-box binding protein 1, 030220 oncology & carcinogenesis, HCC, hepatocellular carcinomas, Vps34, phosphatidylinositol 3-kinase catalytic subunit type 3, CK1/2, casein kinase I/II, COMMD1, copper metabolism domain containing 1, KLHL3, kelch like family member 3, EMT, epithelial–mesenchymal transition, Cullin, P-TEFb, positive transcription elongation factor b, CDK2/4, cyclin dependent kinase 2/4, SPOP, speckle-type POZ protein, AIRE, autoimmune regulator, PYGO2, pygopus 2, TCOF1, treacle ribosome biogenesis factor 1, ID2, inhibitor of DNA binding 2, CHK1, checkpoint kinase 1, Kinases, FZR1, fizzy and cell division cycle 20 related 1, HIF1α, NF-κB and hypoxia inducible factor 1 subunit alpha, EXO1, exonuclease 1, ZBTB16, zinc finger and BTB domain containing 16, NOLC1, nucleolar and coiled-body phosphoprotein 1, 03 medical and health sciences, PKM2, pyruvate kinase M2 isoform, KDM2B, lysine demethylase 2B, PKC, protein kinase C, Cullin-RING ligases, medicine, BMAL1, aryl hydrocarbon receptor nuclear translocator like, ATR, ataxia telangiectasia-mutated and Rad3-related, SOCS6, suppressor of cytokine signaling 6, 030304 developmental biology, PDL1, programmed death ligand 1, HIB, Hedghog-induced MATH and BTB domain-containing protein, AKT, AKT serine/threonine kinase, lcsh:RM1-950, Ubiquitination, TRF1, telomeric repeat binding factor 1, DDB1, damage specific DNA binding protein 1, BCL2, BCL2 apoptosis regulator, CLOCK, clock circadian regulator, MYC, MYC proto-oncogene, bHLH transcription factor, lcsh:Therapeutics. Pharmacology, c-Fos, Fos proto-oncogene, AP-1 transcription factor subunit, RARα, RA receptor α, Tumorigenesis, biology.protein, Suppressor, CRY1, cryptochrome circadian regulator 1, ERG, ETS transcription factor ERG, Carcinogenesis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27b7f488f3a53677836e1b8e5b2722dTest
https://doi.org/10.1016/j.apsb.2020.09.007Test

المؤلفون: Zhigang Zhang, Jiaqing Ma, Di Lu, Wanlu Shen, Lechun Lyu

المصدر: Molecular Diagnosis & Therapy. 25:29-40

مصطلحات موضوعية: 0301 basic medicine, TRAF4, SUMO protein, SMAD, Parkin, Deubiquitinating enzyme, Cicatrix, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, Genetics, Humans, Pharmacology, biology, Ubiquitin-Protein Ligases, Ubiquitin-Protein Ligase Complexes, General Medicine, Cell biology, 030104 developmental biology, Gene Expression Regulation, Proteasome, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6893502719d220c928e83ba2c8d30738Test
https://doi.org/10.1007/s40291-020-00509-zTest

المؤلفون: Masahiro Shimizu, Atsushi Sato, Nobuyuki Tanaka, Hiroyuki Kagechika, Toshiyasu Goto, Hiroyuki Masuno, Hiroshi Shibuya

المصدر: Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Communications Biology

مصطلحات موضوعية: 0301 basic medicine, Male, Lysine, Regulator, Medicine (miscellaneous), Protein Serine-Threonine Kinases, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Ubiquitin, WNK Lysine-Deficient Protein Kinase 1, Cell Line, Tumor, medicine, Animals, Humans, Wnt Signaling Pathway, lcsh:QH301-705.5, beta Catenin, Cancer, Mutation, Mice, Inbred BALB C, biology, Chemistry, Kinase, urogenital system, Wnt signaling pathway, Ubiquitination, Ubiquitin-Protein Ligase Complexes, Growth factor signalling, Ubiquitin ligase, Cell biology, 030104 developmental biology, lcsh:Biology (General), Ubiquitin ligases, 030220 oncology & carcinogenesis, Catenin, biology.protein, General Agricultural and Biological Sciences

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff2b5a5e2c24fc299e8297d42729452Test
http://link.springer.com/article/10.1038/s42003-020-01386-2Test

المؤلفون: Jackson Mittlesteadt, Yini Zhu, Xiaofei Wen, Xin Lu, Jiling Wen, Gang Huang

المصدر: The Prostate. 81:81-88

مصطلحات موضوعية: Male, 0301 basic medicine, Genome instability, DNA damage, Urology, Prostatic Hyperplasia, RAD51, Gene Expression, Biology, SPOP, medicine.disease_cause, Small hairpin RNA, Mice, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, medicine, Animals, Humans, Mice, Knockout, DNA Helicases, Prostate, Nuclear Proteins, Prostatic Neoplasms, Ubiquitin-Protein Ligase Complexes, Epithelial Cells, medicine.disease, DNA-Binding Proteins, Mice, Inbred C57BL, Repressor Proteins, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Mutation, Cancer research, Homologous recombination, Carcinogenesis, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d43fb60dbc2fc64c5c268afd99cb1eTest
https://doi.org/10.1002/pros.24080Test

المؤلفون: Susumu Imaoka, Ferbian Milas Siswanto, Ami Oguro, Saki Arase

المصدر: Drug Metabolism and Pharmacokinetics. 35:441-455

مصطلحات موضوعية: Gene isoform, NF-E2-Related Factor 2, Regulator, Pharmaceutical Science, digestive system, environment and public health, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Tumor Cells, Cultured, Humans, Pharmacology (medical), Caenorhabditis elegans, 030304 developmental biology, Pharmacology, 0303 health sciences, Gene knockdown, Kelch-Like ECH-Associated Protein 1, biology, Chemistry, Ubiquitin-Protein Ligase Complexes, respiratory system, biology.organism_classification, Cytoprotection, KEAP1, Cell biology, Cytoplasm, Immunostaining, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b024c86a3a0019f775aa732f701b325dTest
https://doi.org/10.1016/j.dmpk.2020.06.007Test

المؤلفون: Guo‑Qian He, Wei Zhang, Yan Chen, Wen‑Ming Xu, Hui‑Juan Liao, Guo‑Lin He

المصدر: Molecular Medicine Reports

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, HECT, Autophagy-Related Proteins, Apoptosis, UPS, Biochemistry, Brain Ischemia, Wortmannin, Small hairpin RNA, Rats, Sprague-Dawley, chemistry.chemical_compound, 0302 clinical medicine, Cells, Cultured, Cerebral Cortex, Neurons, biology, Articles, Ubiquitin ligase, Cell biology, Oncology, 030220 oncology & carcinogenesis, Reperfusion Injury, Molecular Medicine, Female, Signal Transduction, autophagy, China, Proteasome Endopeptidase Complex, Ubiquitin-Protein Ligases, ATG5, Caspase 3, Protein degradation, 03 medical and health sciences, Genetics, Animals, Molecular Biology, Ubiquitin, Autophagy, OGD/R, UBA and WWE domain containing E3 ubiquitin protein ligase 1, Rats, Oxygen, 030104 developmental biology, Glucose, chemistry, Proteasome, Proteolysis, biology.protein, Apoptosis Regulatory Proteins, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2442977baac61fff571374f51dfda07aTest
http://europepmc.org/articles/PMC7646962Test