دورية أكاديمية
Tubulointerstitial nephritis and uveitis (TINU) syndrome in a 52-year-old female: A case report and review of the literature
| العنوان: | Tubulointerstitial nephritis and uveitis (TINU) syndrome in a 52-year-old female: A case report and review of the literature |
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| المؤلفون: | Liakopoulos, V., Ioannidis, I., Zengos, N., Karabatsas, C., Karasavvidou, F., Salmas, M., Kanelaki, E., Eleftheriadis, T., Stefanidis, I. |
| المصدر: | Renal Failure ; http://www.scopus.com/inward/record.url?eid=2-s2.0-33745562794&partnerID=40&md5=2d3e09f46c8d429b537eccd6df5d0f3cTest |
| سنة النشر: | 2006 |
| المجموعة: | University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: | Steroid therapy, Tubulointerstitial nephritis, Uveitis, corticosteroid, creatinine, cyclopentolate, dexamethasone, methylprednisolone, omeprazole, recombinant erythropoietin, adult, anemia, anorexia, article, case report, corticosteroid therapy, creatinine blood level, differential diagnosis, erythrocyte sedimentation rate, female, fever, human, interstitial nephritis, iridocyclitis, kidney biopsy, kidney failure, kidney function, metabolic acidosis, nausea, priority journal |
| الوصف: | Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare entity first described in 1975, affecting mainly young women and adolescents. We present a case of a 52-year-old female patient (one of the oldest in the literature) who complained of fever, anorexia, nausea, and vomiting. After she was admitted to our hospital, laboratory tests revealed tubular proteinuria, elevated erythrocyte sedimentation rate (ESR), anemia, and renal insufficiency (serum creatinine 4.2 mg/dL) with metabolic acidosis. Ophthalmologic examination revealed anterior uveitis (iritis) and renal biopsy showed acute tubulointerstitial nephritis. The diagnosis of TINU syndrome was established and the patient was treated with oral corticosteroids. All symptoms and ophthalmologic abnormalities disappeared after 6 weeks of treatment. Renal function also recovered completely and remained stable at follow-up. TINU syndrome should be considered in the differential diagnosis of unexplained tubulointerstitial nephritis, especially in the presence of ocular findings. Corticosteroid therapy is still controversial, but it helps in the quick resolution of renal and mainly eye abnormalities. Copyright © Taylor & Francis Group, LLC. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0886022X |
| العلاقة: | http://hdl.handle.net/11615/30293Test |
| DOI: | 10.1080/08860220600577775 |
| الإتاحة: | https://doi.org/10.1080/08860220600577775Test http://hdl.handle.net/11615/30293Test |
| رقم الانضمام: | edsbas.8DF73A1A |
| قاعدة البيانات: | BASE |
| تدمد: | 0886022X |
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| DOI: | 10.1080/08860220600577775 |