دورية أكاديمية
ATM and ATR checkpoint kinase pathways: A concise review
| العنوان: | ATM and ATR checkpoint kinase pathways: A concise review |
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| المؤلفون: | Varsha Wagh, Pranav Joshi, Heena Jariyal, Neelam Chauhan |
| المصدر: | Advances in Human Biology, Vol 10, Iss 2, Pp 51-59 (2020) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | 9-1-1 complex, ataxia-telangiectasia-mutated and rad3-related, ataxia-telangiectasia-mutated, checkpoint kinase 1, checkpoint kinase 2, dna damage repair pathway, mre11– rad50–nbs1 complex, Biology (General), QH301-705.5 |
| الوصف: | The ataxia-telangiectasia-mutated (ATM) and ataxia-telangiectasia-mutated and Rad3-related (ATR) DNA damage repair pathways serve as the surveillance system which keeps a check on different types of DNA damages and lesions, which includes DNA single-strand breaks, DNA double-strand breaks and other aberrant structures such as arrested replication forks during replication. The ATM and ATR kinases belong to PIKK class of kinases which activate a large number of downstream mediator and effector molecules. The main classes of effector kinases activated by ATM and ATR are checkpoint kinase 2 and checkpoint kinase 1, respectively. ATR works primarily with the RAD9-RAD1-HUS1 (9-1-1) complex, whereas ATM works with the MRE11– RAD50–NBS1 complex. Together ATM and ATR kinase protects the cells' genomic integrity and prevents random mutations to be carried into their progeny. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2321-8568 2348-4691 41858360 |
| العلاقة: | http://www.aihbonline.com/article.asp?issn=2321-8568;year=2020;volume=10;issue=2;spage=51;epage=59;aulast=WaghTest; https://doaj.org/toc/2321-8568Test; https://doaj.org/toc/2348-4691Test |
| DOI: | 10.4103/AIHB.AIHB_78_19 |
| الوصول الحر: | https://doaj.org/article/a779fa9ec1bd418583608edc5590235eTest |
| رقم الانضمام: | edsdoj.779fa9ec1bd418583608edc5590235e |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 23218568 23484691 41858360 |
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| DOI: | 10.4103/AIHB.AIHB_78_19 |