التفاصيل البيبلوغرافية
| العنوان: |
Association of HLA‐DRB1*09:01 with severe COVID‐19. |
| المؤلفون: |
Anzurez, Alitzel, Naka, Izumi, Miki, Shoji, Nakayama‐Hosoya, Kaori, Isshiki, Mariko, Watanabe, Yusuke, Nakamura‐Hoshi, Midori, Seki, Sayuri, Matsumura, Takayuki, Takano, Tomohiro, Onodera, Taishi, Adachi, Yu, Moriyama, Saya, Terahara, Kazutaka, Tachikawa, Natsuo, Yoshimura, Yoshihiro, Sasaki, Hiroaki, Horiuchi, Hiroshi, Miyata, Nobuyuki, Miyazaki, Kazuhito |
| المصدر: |
HLA: Immune Response Genetics; Jul2021, Vol. 98 Issue 1, p37-42, 6p |
| مصطلحات موضوعية: |
COVID-19, CARDIOVASCULAR diseases |
| مستخلص: |
HLA‐A, ‐C, ‐B, and ‐DRB1 genotypes were analyzed in 178 Japanese COVID‐19 patients to investigate the association of HLA with severe COVID‐19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA‐DRB1*09:01 and severe COVID‐19 (odds ratio [OR], 3.62; 95% CI, 1.57–8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus were adjusted. The DRB1*09:01 allele was more significantly associated with risk for severe COVID‐19 compared to preexisting medical conditions such as hypertension, diabetes, and cardiovascular diseases. These results indicate a potential role for HLA in predisposition to severe COVID‐19. [ABSTRACT FROM AUTHOR] |
|
Copyright of HLA: Immune Response Genetics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
