التفاصيل البيبلوغرافية
| العنوان: |
Mitochondrial DNA variants and Cognitive Function |
| المؤلفون: |
Odden, Michelle, Li, Yongmei, Jotwani, Vasantha, McGeever, Lea, Jones, Robyn, Desprez, Pierre‐Yves, Tranah, Gregory J. |
| المصدر: |
Alzheimer's & Dementia ; volume 19, issue S15 ; ISSN 1552-5260 1552-5279 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2023 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Background Mitochondrial dysfunction is a hallmark of aging and manifests in age‐associated disorders, including neurodegenerative diseases. Previous work on mitochondrial DNA variants and neurocognitive outcomes has been limited to known variants of interest. Method We sequenced the mitochondrial genome in buffy coat samples from two studies, LIFE (Lifestyle Interventions and Independence for Elders) and HABC (Health Aging and Body Composition), and examined the association of shared common variants and cognitive function, after adjustment for 10 principal components to account for population stratification. Participants included self‐reported Black (n = 229 in LIFE and 393 in HABC) and White (n = 1134 in LIFE and 395 in HABC) adults aged ≥ 70 years. Cognitive function was measured by the digit‐symbol substitution test (DSST), a measure of processing speed, and the Modified Mini‐Mental State Exam (3MSE), a measure of global cognition. Result There were 96 variants which had a minor‐allele frequency ≥5% in both studies. There were 8 variants associated with DSST in White participants LIFE at the p<0.05 level and 1 at the Bonferroni‐adjusted level (m16223ct). Four reached statistical significance at the p<0.05 level in meta‐analyses of LIFE and HABC (m16223ct, m16093tc, m10873tc, m3106cnc). There were 7 variants associated with 3MSE in White participants in LIFE at the p<0.05 level and none at the Bonferroni‐adjusted level. One reached statistical significance at the p<0.05 level in meta‐analyses of LIFE and HABC (m10873tc). In Black participants, the variants had differential associations with the cognitive outcomes by study, and no associations reached statistical significance after Bonferroni correction or in meta‐analysis. The 4 variants of interest in White participants are located in the 1) hypervariable region 1 of the D‐loop (m16093tc, m16223ct), 2) gene MT‐ND4 coding for subunit ND4 of complex 1 (m10873tc), and 3) gene MT‐RNR2 coding for the 16S ribosomal RNA (m3106cnc). Conclusion ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/alz.077291 |
| الإتاحة: |
https://doi.org/10.1002/alz.077291Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.6BE112B5 |
| قاعدة البيانات: |
BASE |
