التفاصيل البيبلوغرافية
| العنوان: |
Biologics in Asthma and Chronic Obstructive Pulmonary Disorder. |
| المؤلفون: |
Cazzola, Mario, Matera, Maria Gabriella, Calzetta, Luigino, Rogliani, Paola |
| المصدر: |
touchREVIEWS in Respiratory & Pulmonary Diseases; 2022, Vol. 7 Issue 1, p1-1, 1p |
| مصطلحات موضوعية: |
MONOCLONAL antibodies, ASTHMA treatment, IMMUNOGLOBULIN E, INTERLEUKIN-5, CHEMOKINES |
| مستخلص: |
Several cytokines and chemokines play a potential role in the pathogenesis of asthma and chronic obstructive pulmonary disorder (COPD). Their inhibition by monoclonal antibodies (mAbs) that can block them or prevent their synthesis, antagonize their receptors or affect intracellular signalling pathways may, in the right patient, inhibit the inflammatory process that likely supports the progressive nature of these disorders. These biological agents are divided into those that target type 2 (T2)-mediated inflammation by blocking interleukin (IL)-5 and/or its receptor, preventing IL-4 and IL-13 signalling, affecting the IL-33 pathway and blocking thymic stromal lymphopoietin, and those that target specific pro-inflammatory and pro-neutrophilic cytokines and chemokines such as tumour necrosis factor-a, IL-1, IL-8 and IL-1ß. Most biological therapies developed to date target T2 cytokines, alarmins or immunoglobulin E. This article reviews the most recent advances in the potential role of cytokines and chemokines in asthma and COPD, and describes the mAbs already approved to treat T2 inflammation in asthma, the potential benefit of using anti-IL-33 mAbs, and the therapeutic potential of some of these mAbs in COPD. Unfortunately, no biological treatments have been specifically licensed for the treatment of type 1 inflammation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
