دورية أكاديمية
Cholinergic blockade under working memory demands encountered by increased rehearsal strategies: evidence from fMRI in healthy subjects
| العنوان: | Cholinergic blockade under working memory demands encountered by increased rehearsal strategies: evidence from fMRI in healthy subjects |
|---|---|
| المؤلفون: | Voss, B., Thienel, R., Reske, M., Kellermann, T., Sheldrick, A.J., Halfter, S., Radenbach, K., Shah, N.J., Habel, U., Kircher, T.T. |
| المصدر: | European archives of psychiatry and clinical neuroscience 262, 329 - 339 (2012). doi:10.1007/s00406-011-0267-6 |
| بيانات النشر: | Steinkopff |
| سنة النشر: | 2012 |
| المجموعة: | Forschungszentrum Jülich: JuSER (Juelich Shared Electronic Resources) |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/610, Adult, Down-Regulation: physiology, Executive Function: drug effects, Executive Function: physiology, Humans, Magnetic Resonance Imaging: methods, Male, Memory, Short-Term: drug effects, Short-Term: physiology, Muscarinic Antagonists: pharmacology, Neuropsychological Tests, Prefrontal Cortex: drug effects, Prefrontal Cortex: physiology, Reaction Time: drug effects, Reaction Time: physiology, Receptors, Muscarinic: physiology, Scopolamine Hydrobromide: pharmacology, Single-Blind Method, Synaptic Transmission: drug effects, Synaptic Transmission: physiology, Muscarinic Antagonists, Muscarinic, Scopolamine Hydrobromide, Cholinergic system, Scopolamine, Muscarinic antagonist |
| جغرافية الموضوع: | DE |
| الوصف: | The connection between cholinergic transmission and cognitive performance has been established in behavioural studies. The specific contribution of the muscarinic receptor system on cognitive performance and brain activation, however, has not been evaluated satisfyingly. To investigate the specific contribution of the muscarinic transmission on neural correlates of working memory, we examined the effects of scopolamine, an antagonist of the muscarinic receptors, using functional magnetic resonance imaging (fMRI). Fifteen healthy male, non-smoking subjects performed a fMRI scanning session following the application of scopolamine (0.4 mg, i.v.) or saline in a placebo-controlled, repeated measure, pseudo-randomized, single-blind design. Working memory was probed using an n-back task. Compared to placebo, challenging the cholinergic transmission with scopolamine resulted in hypoactivations in parietal, occipital and cerebellar areas and hyperactivations in frontal and prefrontal areas. These alterations are interpreted as compensatory strategies used to account for downregulation due to muscarinic acetylcholine blockade in parietal and cerebral storage systems by increased activation in frontal and prefrontal areas related to working memory rehearsal. Our results further underline the importance of cholinergic transmission to working memory performance and determine the specific contribution of muscarinic transmission on cerebral activation associated with executive functioning. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/issn/0940-1334; info:eu-repo/semantics/altIdentifier/pmid/pmid:22006639; info:eu-repo/semantics/altIdentifier/wos/WOS:000304815300007; https://juser.fz-juelich.de/record/22042Test; https://juser.fz-juelich.de/search?p=id:%22PreJuSER-22042%22Test |
| الإتاحة: | https://doi.org/10.1007/s00406-011-0267-6Test https://juser.fz-juelich.de/record/22042Test https://juser.fz-juelich.de/search?p=id:%22PreJuSER-22042%22Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.D0DAA3A3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |